Multiple metals exposure and neurotoxic risk in bald eagles (Haliaeetus leucocephalus) from two Great Lakes states

Environmental Toxicology and Chemistry

Volumn 31, Issue 3, 2012, Pages 623-631

  Nam, Dong Ha ^a   Rutkiewicz, Jennifer ^a   Basu, Niladri ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Brain; Heavy metals; Lead; Neurochemical biomarkers; Neurotoxicology; Wildlife toxicology

Indexed keywords

AMINOBUTYRIC ACIDS; BALD EAGLES; GABAERGIC; GLUTAMIC ACID DECARBOXYLASE; GLUTAMINE SYNTHETASE; GREAT LAKES; MICHIGAN; MINNESOTA; MULTIPLE METALS; N-METHYL-D-ASPARTATE; NEUROCHEMICAL RECEPTORS; NEUROTOXICOLOGY; NMDA RECEPTOR; RECEPTOR LEVELS; WILDLIFE TOXICOLOGY;

AMINO ACIDS; BRAIN; CADMIUM; COPPER; HEAVY METALS; LAKES; LEAD; MANGANESE; ZINC;

POLLUTION;

4 AMINOBUTYRIC ACID; ANTIMONY; ARSENIC; CADMIUM; CHROMIUM; COBALT; COPPER; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DECARBOXYLASE; LEAD; MANGANESE; N METHYL DEXTRO ASPARTIC ACID; ZINC;

BIOACCUMULATION; BIOCHEMISTRY; BIOMARKER; BRAIN; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; HEAVY METAL; LEAD; POLLUTION EXPOSURE; RAPTOR; RISK FACTOR; TOXICOLOGY; WILD POPULATION;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN LEVEL; EAGLE; HALIAEETUS LEUCOCEPHALUS; LAKE; LIVER LEVEL; NEUROCHEMISTRY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION; UNITED STATES;

ANIMALS; BRAIN; EAGLES; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; GAMMA-AMINOBUTYRIC ACID; LIVER; MALE; METALS; MICHIGAN; MINNESOTA; NERVOUS SYSTEM; REPRODUCTION;

GREAT LAKES [NORTH AMERICA]; MICHIGAN; MINNESOTA; UNITED STATES;

ACCIPITRIDAE; AVES; HALIAEETUS LEUCOCEPHALUS; VERTEBRATA;

EID: 84857504652     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.1712     Document Type: Article

References (40)

1. Bowerman WW, Best DA, Grubb TG, Sikarskie JG, Giesy JP. 2000. Assessment of environmental endocrine disruptors in bald eagles of the Great Lakes. Chemosphere 41: 1569- 1574.
2. Bowerman WW, Best DA, Giesy OP, Shieldcastle MC, Meyer MW, Postupalsky S, Sikarskie JG. 2003. Associations between regional differences in polychlorinated biphenyls and dichlorodiphenyldichloroethylene in blood of nestling bald eagles and reproductive productivity. Environ Toxicol Chem 22: 371- 376.
3. Wayland M, Neugebauer E, Bollinger T. 1999. Concentrations of lead in liver, kidney, and bone of bald and golden eagles. Arch Environ Contam Toxicol 37: 267- 272.
4. Miller MJ, Wayland ME, Bortolotti GR. 2001. Exposure of migrant bald eagles to lead in prairie Canada. Environ Pollut 112: 153- 162.
5. Stout JH, Trust KA. 2002. Elemental and organochlorine residues in bald eagles from Adak Island, Alaska. J Wildl Dis 38: 511- 517.
6. Desmarchelier M, Santamaria-Bouvier A, Fitzgérald G, Lair S. 2010. Mortality and morbidity associated with gunshot in raptorial birds from the province of Quebec: 1986 to 2007. Can Vet J 51: 70- 74.
7. Scheuhammer AM, Basu N, Burgess NM, Elliott JE, Campbell GD, Wayland M, Champoux L, Rodrigue J. 2008. Relationships among mercury, selenium, and neurochemical parameters in common loons (Gavia immer) and bald eagles (Haliaeetus leucocephalus). Ecotoxicology 17: 93- 101.
8. Rutkiewicz J, Nam DH, Cooley T, Neumann K, Padilla IB, Route W, Strom S, Basu N. 2011. Mercury exposure and neurochemical impacts in bald eagles across several Great Lakes states. Ecotoxicology 20: 1669- 1676.
9. Trudeau VL, Spanswick D, Fraser EJ, Lariviere K, Crump D, Chiu S, MacMillan M, Schulz RW. 2000. The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish. Biochem Cell Biol 78: 241- 259.
10. Gibbs ME, Johnston GA. 2005. Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks. Neuroscience 131: 567- 576.
11. Basu N, Klenavic K, Gamberg M, O'Brien M, Evans D, Scheuhammer AM, Chan HM. 2005. Effects of mercury on neurochemical receptor-binding characteristics in wild mink. Environ Toxicol Chem 24: 1444- 1450.
12. Basu N, Stamler CJ, Loua KM, Chan HM. 2005. An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum. Toxicol Appl Pharmacol 205: 71- 76.
13. Basu N, Kwan M, Chan HM. 2006. Mercury but not organochlorines inhibits muscarinic cholinergic receptor binding in the cerebrum of ringed seals (Phoca hispida). J Toxicol Environ Health A 69: 1133- 1143.
14. Basu N, Scheuhammer AM, Rouvinen-Watt K, Grochowina N, Klenavic K, Evans RD, Chan HM. 2006. Methylmercury impairs components of the cholinergic system in captive mink (Mustela vison). Toxicol Sci 91: 202- 209.
15. Basu N, Scheuhammer AM, Evans RD, O'Brien M, Chan HM. 2007. Cholinesterase and monoamine oxidase activity in relation to mercury levels in the cerebral cortex of wild river otters. Hum Exp Toxicol 26: 213- 220.
16. Basu N, Scheuhammer AM, Rouvinen-Watt K, Grochowina N, Evans RD, O'Brien M, Chan HM. 2007. Decreased N-methyl-D-aspartic acid (NMDA) receptor levels are associated with mercury exposure in wild and captive mink. Neurotoxicology 28: 587- 593.
17. Basu N, Scheuhammer AM, Sonne C, Letcher RJ, Born EW, Dietz R. 2009. Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)? Environ Toxicol Chem 28: 133- 140.
18. Aronstam RS, Elderfrawi ME. 1979. Transition and heavy metal inhibition of ligand binding to muscarinic acetylcholine receptors from rat brain. Toxicol Appl Pharmacol 48: 489- 496.
19. Reynolds IJ, Miller RJ. 1988. [3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: Evidence for multiple regulatory sites. Eur J Pharmacol 151: 103- 112.
20. Shellenberger MK. 1984. Effects of early lead exposure on neurotransmitter systems in the brain. A review with commentary. Neurotoxicology 5: 177- 212.
21. Bechard MJ, Perkins DN, Kaltenecker GS, Alsup S. 2009. Mercury contamination in Idaho bald eagles, Haliaeetus leucocephalus Bull Environ Contam Toxicol 83: 698- 702.
22. Basu N, Nam D-H, Kwansah-Ansah E, Renne E, Nriagu J. 2011. Multiple metals exposures among small-scale artisanal gold miners. Environ Res 111: 463- 467.
23. Nam DH, Adams DH, Flewelling LJ, Basu N. 2010. Neurochemical alterations in lemon shark (Negaprion brevirostris) brains in association with brevetoxin exposure. Aquat Toxicol 99: 351- 359.
24. Zillioux E, Porcella D, Benoit J. 1993. Mercury cycling and effects in freshwater wetland ecosystems. Environ Toxicol Chem 12: 2245- 2264.
25. Puls R. 1994. Mineral levels in animal health. Sherpa International, Clearbrook, CA.
26. Beyer W, Heinz G, Redmon-Norwood AW, eds. 1996. Environmental Contaminants in Wildlife. Interpreting Tissue Concentrations. Lewis/CRC, Boca Raton, FL, USA.
27. Kaiser TE, Reichel WL, Locke LN, Cromartie E, Krynitsky AJ, Lamont TG, Mulhern BM, Prouty RM, Stafford CJ, Swineford DM. 1980. Organochlorine pesticide, PCB, and PBB residues and necropsy data for bald eagles from 29 states-1975-77. Pestic Monit J 13: 145- 149.
28. Craig T, Connely J, Craig E, Parker T. 1990. Lead concentrations in golden and bald eagles. Wilson Bull 102: 130- 133.
29. Kenntner N, Tataruch F, Krone O. 2001. Heavy metals in soft tissue of white-tailed eagles found dead or moribund in Germany and Austria from 1993 to 2000. Environ Toxicol Chem 20: 1831- 1837.
30. Goldstein GW, Asbury AK, Diamond I. 1974. Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries. Arch Neurol 31: 382- 389.
31. Lewis J, Sjöström J, Skyllberg U, Hägglund L. 2010. Distribution, chemical speciation, and mobility of lead and antimony originating from small arms ammunition in a coarse-grained unsaturated surface sand. J Environ Qual 39: 863- 870.
32. Asakura K, Satoh H, Chiba M, Okamoto M, Serizawa K, Nakano M, Omae K. 2009. Genotoxicity studies of heavy metals: Lead, bismuth, indium, silver and antimony. J Occup Health 51: 498- 512.
33. Garitano-Zavala A, Cotin J, Borras M, Nadal J. 2010. Trace metal concentrations in tissues of two tinamou species in mining areas of Bolivia and their potential as environmental sentinels. Environ Monit Assess 168: 629- 644.
34. Zurich MG, Monnet-Tschudi F, Berode M, Honegger P. 1998. Lead acetate toxicity in vitro: Dependence on the cell composition of the cultures. Toxicol In Vitro 12: 191- 196.
35. Memo M, Lucchi L, Spano PF, Trabucchi M. 1980. Effect of chronic lead treatment on GABA-ergic receptor function in rat brain. Toxicol Lett 6: 427- 432.
36. Toki H, Namikawa K, Su Q, Kiryu-Seo S, Sato K, Kiyama H. 1998. Enhancement of extracellular glutamate scavenge system in injured motoneurons. J Neurochem 71: 913- 919.
37. Suh SW, Aoyama K, Alano CC, Anderson CM, Hamby AM, Swanson RA. 2007. Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1. Mol Med 13: 344- 349.
38. Sorg O, Horn TF, Yu N, Gruol DL, Bloom FE. 1997. Inhibition of astrocyte glutamate uptake by reactive oxygen species: role of antioxidant enzymes. Mol Med 3: 431- 440.
39. Mahesh VB, Brann DW. 2005. Regulatory role of excitatory amino acids in reproduction. Endocrine 28: 271- 280.
40. Stamler CJ, Basu N, Chan HM. 2005. Biochemical markers of neurotoxicity in wildlife and human populations: Considerations for method development. J Toxicol Environ Health A 68: 1413- 1429.