Environmental risk assessment for ancillary substances in biotechnological production of pharmaceuticals

Environmental Toxicology and Chemistry

Volumn 31, Issue 3, 2012, Pages 681-687

  Straub, Jürg Oliver ^a   Gysel, Daniel ^a   Kastl, Ursula ^b   Klemmer, Jürgen ^b   Sonderegger, Marco ^a   Studer, Martin ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ROCHE INNOVATION CENTER MUNICH   (Germany)

Author keywords

Ancillary substances; Biotechnological production; Environmental risk assessment; Pharmaceuticals

Indexed keywords

ACTIVATED SLUDGE; ACTIVE SUBSTANCE; ACUTE TOXICITY; AFTER-TREATMENT; ANCILLARY SUBSTANCES; BIOTECHNOLOGICAL PROCESS; BIOTECHNOLOGICAL PRODUCTION; DAPHNIDS; DILUTION FACTORS; ECOTOXICITY; ENVIRONMENTAL CONDITIONS; ENVIRONMENTAL DATA; ENVIRONMENTAL RISK ASSESSMENT; ETHYLENE DIAMINE TETRA-ACETIC ACID; GENTAMYCIN; GERMANY; HOFFMANN-LA ROCHE; HOST ORGANISM; MANUFACTURING PROCESS; POTENTIAL RISKS; PREDICTED ENVIRONMENTAL CONCENTRATIONS; PREDICTED NO-EFFECT CONCENTRATIONS; RECEIVING WATERS; RISK CHARACTERIZATION RATIOS; SITE-SPECIFIC; SULFONIC ACID; SWITZERLAND; WASTEWATER TREATMENT PLANTS;

BIODEGRADATION; BIOTECHNOLOGY; CHELATION; DRUG PRODUCTS; EFFLUENT TREATMENT; EFFLUENTS; OPTIMIZATION; PRODUCTION ENGINEERING; RISK ASSESSMENT; SURFACE WATERS; TOXICITY;

ANTIBIOTICS;

1,4 PIPERAZINE(DIETHANESULFONIC ACID); ANCILLARY SUBSTANCE; BUFFER; CHEMICAL AGENT; EDETIC ACID; GENTAMICIN; MORPHOLINOETHANE SULFONIC ACID; MORPHOLINOPROPANE SULFONIC ACID; SURFACE WATER; UNCLASSIFIED DRUG;

ACTIVATED SLUDGE; ALGA; BIODEGRADATION; BIOTECHNOLOGY; CRUSTACEAN; DRUG; ECOTOXICOLOGY; ENVIRONMENTAL CONDITIONS; ENVIRONMENTAL RISK; FISH; GROWTH; INHIBITION; PURIFICATION; RISK ASSESSMENT; SURFACE WATER; TOXICITY TEST; WASTEWATER; WATER TREATMENT;

ACTIVATED SLUDGE; ARTICLE; BIODEGRADABILITY; BIODEGRADATION; CONCENTRATION (PARAMETERS); DRUG INDUSTRY; ECOTOXICITY; ENVIRONMENTAL IMPACT ASSESSMENT; ENVIRONMENTAL RISK ASSESSMENT; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; WASTE WATER TREATMENT PLANT;

ANIMALS; AQUATIC ORGANISMS; BIOLOGICAL AGENTS; BIOTECHNOLOGY; ENVIRONMENTAL MONITORING; RISK ASSESSMENT; SEWAGE; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL;

BAVARIA; GERMANY; PENZBERG; SWITZERLAND;

ALGAE; DAPHNIIDAE;

EID: 84857500257     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.1733     Document Type: Article

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