Protein and peptide therapeuticals: An example of "benign by nature" active pharmaceutical ingredients

Green and Sustainable Pharmacy

Volumn , Issue , 2010, Pages 127-133

  Straub, Jürg Oliver ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84857508217     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-05199-9_8     Document Type: Chapter

References (15)

1. Allergan (2007) BOTOX R (Botulinum Toxin Type A); http://www.allergan. com/site/products/consumers/home.asp?id =botox, accessed 7 March 2008
2. Alouf JE, Popoff MR (eds.) (2005) The Comprehensive Sourcebook of Bacterial Protein Toxins. 3rd edition, Academic Press, New York
3. Clariant (2002) Safety data sheet for Polyglycol 6000P, 27.02.2002. Clariant Ltd, Basle, Switzerland
4. Eberius M, Mennicken G, Reuter I, Vandenhirtz J (2002) Sensitivity of different growth inhibition tests-just a question of mathematical calculation? Theory and practice for algae and duckweed. Ecotoxicology 11, 293-297
5. EMEA (2006) Note for Guidance on Environmental Risk Assessment of Medicinal Products for Human Use. CPMP/SWP/4447/00. EMEA, London; http://www.emea.eu.int/pdfs/human/swp/444700en.pdf, accessed 7 March 2008
6. Frohne D, Pfänder HJ (2005) Poisonous Plants. 2nd edition, Blackwell, Oxford, UK
7. Hutchinson TH, Barrett S, Buzby M, Constable D, Hartmann A, Hayes E, Huggett D, Länge R, Lillicrap AD, Straub JO, Thompson RS (2003) A strategy to reduce the numbers of fish used in acute ecotoxicity testing of pharmaceuticals. Environ Toxicol Chem 22, 3031-3036
8. Leader B, Baca QJ, Golan DE (2008) Protein therapeutics: a summary and pharmacological classification. Nat Rev Drug Discov 7, 21-39
9. Mebs D (2002) Venomous and Poisonous Animals: A Handbook for Biologists, Toxicologists and Toxinologists, Physicians and Pharmacists. Medpharm, Stuttgart, Germany
10. OECD (1992a) OECD Guideline for Testing of Chemicals, Test no. 301, adopted by the Council on 17th July 1992: Ready Biodegradability. OECD, Paris, France
11. OECD (1992b) OECD Guideline for Testing of Chemicals, Test no. 203, adopted by the Council on 17th July 1992: Fish, Acute Toxicity Test. OECD, Paris, France
12. OECD (2004) OECD Guideline for Testing of Chemicals, Test no. 202, adopted by the Council on 13th April 2004: Daphnia sp. Acute Immobilisation Test. OECD, Paris, France
13. OECD (2006) OECD Guideline for Testing of Chemicals, Test no. 201, adopted by the Council on 23rd March 2006: Freshwater Alga and Cyanobacteria, Growth Inhibition Test. OECD, Paris, France
14. Watson GK, Jones N (1977) The biodegradation of polyethylene glycols by sewage bacteria. Water Res 11, 95-100
15. Webster R, Didier E, Harris P, Siegel N, Stadler J, Tilbury L, Smith D (2007) PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Drug Metab Dispos 35, 9-16