Protein expression of estrogen receptors α and β and aromatase in myometrium and uterine leiomyoma

Gynecologic and Obstetric Investigation

Volumn 73, Issue 2, 2012, Pages 113-117

  Olmos Grings, Anelise ^a,b   Lora, Vanessa ^b   Dias Ferreira, Gustavo ^b   Simoni Brum, Ilma ^b   Von Eye Corleta, Helena ^a,b,c,d   Capp, Edison ^a,b,c,d  

^a Faculdade de Medicina   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c Instituto de Ciências Básicas da Saúde   (Brazil)

^d FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Aromatase; Estrogen receptor ; Estrogen receptor ; Leiomyoma; Myometrium

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

ABDOMINAL HYSTERECTOMY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MYOMETRIUM; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH; UTERUS MYOMA; WESTERN BLOTTING;

ADULT; AROMATASE; BLOTTING, WESTERN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION; HUMANS; HYSTERECTOMY; LEIOMYOMA; MIDDLE AGED; MYOMETRIUM; PREMENOPAUSE; UTERINE NEOPLASMS;

EID: 84857463509     PISSN: 03787346     EISSN: 1423002X     Source Type: Journal    
DOI: 10.1159/000330700     Document Type: Article

References (22)

1. Stewart EA: Uterine fibroids. Lancet 2001; 357: 293-298. (Pubitemid 32120866)
2. Practice Committee of the American Society for Reproductive Medicine: Myomas and reproductive function. Fertil Steril 2006; 86(suppl):S194-S199.
3. Bakas P, Liapis A, Vlahopoulos S, Giner M, Logotheti S, Creatsas G, Meligova AK, Alexis MN, Zoumpourlis V: Estrogen receptorα andβ in uterine fibroids: a basis for altered estrogen responsiveness. Fertil Steril 2008; 90: 1878-1885.
4. Marshall LM, Spiegelman D, Goldman MB, Manson JE, Colditz G, Barbieri RL, Stampfer MJ, Hunter DJ: A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertil Steril 1998; 70: 432-439. (Pubitemid 28435626)
5. Villanova FE, Andrade PM, Otsuka AY, Gomes MTV, Leal ES, Castro RA, Girão MJBC, Nishimura E, Baracat EC, Silva IDCG: Estrogen receptorα polymorphism and susceptibility to uterine leiomyoma. Steroids 2006; 7I:960-965. (Pubitemid 44573298)
6. Al-Hendy A, Salama S: Ethnic distribution of estrogen receptor-α polymorphism is associated with a higher prevalence of uterine leiomyomas in Black Americans. Fertil Steril 2006; 86: 686-693. (Pubitemid 44307032)
7. Kovács KA, Oszter A, Göcze PM, Környei JL, Szabó I: Comparative analysis of cyclin D1 and oestrogen receptor (α andβ ) levels in human leiomyoma and adjacent myometrium. Mol Hum Reprod 2001; 7: 1085-1091. (Pubitemid 33040972)
8. Sumitani H, Shozu M, Segawa T, Murakami K, Yang H, Shimada K, Inoue M: In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism. Endocrinology 2000; 141: 3852-3860.
9. Brandon DD, Erickson TE, Keenan EJ, Strawn EY, Novy MJ, Burry KA, Warner C, Clinton GM: Estrogen receptor gene expression in human uterine leiomyomata. J Clin Endocrinol Metab 1995; 80: 1876-1881.
10. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjoblom P, Norgren A, Lindblom B: Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 1998; 83: 4092-4096. (Pubitemid 28513601)
11. Lessl M, Klotzbuecher M, Schoen S, Reles A, Stockemann K, Fuhrmann U: Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium. J Clin Endocrinol Metab 1997; 82: 2596-2600. (Pubitemid 27337879)
12. Jakimiuk AJ, Bogusiewicz M, Tarkowski R, Dziduch P, Adamiak A, Wróbel A, Haczynski J, Magoffin DA, Jakowicki JA: Estrogen receptorα andβ expression in uterine leiomyomas from premenopausal women. Fertil Steril 2004; 82: 1244-1249. (Pubitemid 39335945)
13. Bulun SE, Simpson ER, Word RA: Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture. J Clin Endocrinol Metab 1994; 78: 736-743. (Pubitemid 24083321)
14. Folkerd EJ, Newton CJ, Davidson K, Anderson MC, James VHT: Aromatase activity in uterine leiomyomata. J Steroid Biochem Mol Biol 1984; 20: 1195-1200. (Pubitemid 14108622)
15. Hilario SG, Bozzini N, Borsari R, Baracat EC: Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients. Fertil Steril 2009; 91: 240-243.
16. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1976; 72: 248-254.
17. Branchini G, Schneider L, Cericatto R, Capp E, Brum IS: Progesterone receptors A and B and estrogen receptorα expression in normal breast tissue and fibroadenomas. Endocrine 2009; 35: 459-466.
18. Schneider L, Branchini G, Cericatto R, Capp E, Brum IS: Gene and protein expression of p53 and p21 in fibroadenomas and adjacent normal mammary tissue . Endocrine 2009; 35: 118-122.
19. Cericatto R, Pozzobon A, Morsch DM, Menke CH, Brum IS, Spritzer PM: Estrogen receptor-α , bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. Steroids 2005; 70: 153-160. (Pubitemid 40342608)
20. Benassayag C, Leroy MJ, Rigourd V, Robert B, Honoré JC, Mignot TM, Vacher-Lavenu MC, Chapron C, Ferré F: Estrogen receptors (ERα /ERβ ) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma. Am J Physiol 1999; 39:E1112-E1118. (Pubitemid 29323428)
21. Ishikawa H, Reierstad S, Demura M, Rademaker AW, Kasai T, Inoue M, Usui H, Shozu M, Bulun SE: High aromatase expression in uterine leiomyoma tissues of African-American women. J Clin Endocrinol Metab 2009; 94: 1752-1756.
22. Kasai T, Shozu M, Murakami K, Segawa T, Shinohara K, Nomura K, Inoue M: Increased expression of type I 17β -hydroxysteroid dehydrogenase enhances in situ production of estradiol in uterine leiomyoma. J Clin Endocrinol Metab 2004; 89: 5661-5668. (Pubitemid 39518456)