Protease inhibitor levels in periodontal health and disease

Journal of Periodontal Research

Volumn 47, Issue 2, 2012, Pages 228-235

  Kretschmar, S ^a   Yin, L ^b   Roberts, F ^b   London, R ^b   Flemmig, T T ^b   Arushanov, D ^b   Kaiyala, K ^b   Chung, W O ^b  

^a Private Practice   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Gingival crevicular fluid; Periodontitis; Porphyromonas gingivalis; Protease inhibitor

Indexed keywords

ELAFIN; PROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; SQUAMOUS CELL CARCINOMA RELATED ANTIGEN; SQUAMOUS CELL CARCINOMA-RELATED ANTIGEN; TUMOR ANTIGEN;

ADULT; ARTICLE; BACTERIAL LOAD; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; ENZYMOLOGY; FEMALE; GINGIVA BLEEDING; GINGIVITIS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; MICROBIOLOGY; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; PERIODONTIUM; PORPHYROMONAS GINGIVALIS; TOOTH PLAQUE;

ADULT; ANTIGENS, NEOPLASM; BACTERIAL LOAD; CHRONIC PERIODONTITIS; DENTAL PLAQUE; DENTAL PLAQUE INDEX; ELAFIN; FEMALE; GINGIVAL CREVICULAR FLUID; GINGIVAL HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTIUM; PORPHYROMONAS GINGIVALIS; PROTEASE INHIBITORS; SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR; SERPINS;

EID: 84857447017     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2011.01425.x     Document Type: Article

References (45)

1. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994;5:78-111.
2. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998;25:134-144.
3. O'Brien-Simpson NM, Veith PD, Dashper SG, Reynolds EC. Antigens of bacteria associated with periodontitis. Periodontol 2000 2004;35:101-134.
4. Amano A. Molecular interaction of Porphyromonas gingivalis with host cells: implication for the microbial pathogenesis of periodontal disease. J Periodontol 2003;74:90-96.
5. Into T, Inomata M, Kanno Y et al. Arginine-specific gingipains from Porphyromonas gingivalis deprive protective functions of secretory leucocyte protease inhibitor in periodontal tissue. Clin Exp Immunol 2006;145:545-554.
6. Potempa J, Banbula A, Travis J. Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 2000;24:153-192.
7. Imamura T. The role of gingipains in the pathogenesis of periodontal disease. J Periodontol 2003;74:111-118.
8. Imamura T, Potempa J, Tanase S, Travis J. Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain-Rs) from Porphyromonas gingivalis. J Biol Chem 1997;272:16062-16067.
9. Halkier T. Mechanism in Blood Coagulation, Fibriolysis and the Complement System. Cambridge: Cambridge University Press, 1991:302-319.
10. Bizios R, Lai L, Fenton JW 2nd, Malik AB. Thrombin-induced chemotaxis and aggregation of neutrophils. J Cell Physiol 1986;128:485-490.
11. Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999;10:458-476.
12. Watanabe H, Hattori S, Katsuda S, Nakanishi I, Nagai Y. Human neutrophil elastase: degradation of basement membrane components and immunolocalization in the tissue. J Biochem 1990;108:753-759.
13. Giannopoulou C, Di Felice R, Andersen E, Cimasoni G. Synthesis of alpha 2-macroglobulin in human gingiva: a study of the concentration of macroglobulin and albumin in gingival fluid and serum. Arch Oral Biol 1990;35:13-16.
14. Minami M. The levels of secretory leukocyte protease inhibitor and alpha 1-protease inhibitor in gingival crevicular fluid from adult periodontal patients. J Jpn Soc Periodontol 1999;41:28-35.
15. Molhuizen HO, Schalkwijk J. Structural, biochemical, and cell biological aspects of the serine proteinase inhibitor SKALP/elafin/ESI. Biol Chem Hoppe Seyler 1995;376:1-7.
16. Pfundt R, van Ruissen F, van Vlijmen-Willems IM et al. Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. J Clin Invest 1996;98:1389-1399.
17. Cataltepe S, Gornstein ER, Schick C et al. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem 2000;48:113-122.
18. Schick C, Pemberton PA, Shi GP et al. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry 1998;37:5258-5266.
19. Schick C, Kamachi Y, Bartuski AJ et al. Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase. J Biol Chem 1997;272:1849-1855.
20. Yin L, Dale BA. Activation of protective responses in oral epithelial cells by Fusobacterium nucleatum and human beta-defensin-2. J Med Microbiol 2007;56:976-987.
21. Yin L, Swanson B, An J et al. Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2. J Oral Microbiol 2010; Epub May 4.
22. Kantyka T, Latendorf T, Wiedow O et al. Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage. Biol Chem 2009;390:1313-1320.
23. Loe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:(suppl):610-616.
24. Silness J, Loe H. Periodontal disease in pregnancy. 3. Response to local treatment. Acta Odontol Scand 1966;24:747-759.
25. Loe H, Holm-Pedersen P. Absence and presence of fluid from normal and inflamed gingivae. Periodontics 1965;149:171-177.
26. Morillo JM, Lau L, Sanz M, Herrera D, Martin C, Silva A. Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol 2004;31:1054-1060.
27. Nadkarni MA, Martin FE, Jacques NA, Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology 2002;148:257-266.
28. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000 2005;38:135-187.
29. Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 1997;14:12-32.
30. Eley BM, Cox SW. Proteolytic and hydrolytic enzymes from putative periodontal pathogens: characterization, molecular genetics, effects on host defenses and tissues and detection in gingival crevice fluid. Periodontol 2000 2003;31:105-124.
31. Cox SW, Rodriguez-Gonzalez EM, Booth V, Eley BM. Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fluid and saliva from patients with chronic periodontitis. J Periodont Res 2006;41:477-485.
32. Crowley CA, Curnutte JT, Rosin RE et al. An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med 1980;302:1163-1168.
33. Lavine WS, Maderazo EG, Stolman J et al. Impaired neutrophil chemotaxis in patients with juvenile and rapidly progressing periodontitis. J Periodont Res 1979;14:10-19.
34. Kantarci A, Oyaizu K, Van Dyke TE. Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. J Periodontol 2003;74:66-75.
35. Guentsch A, Puklo M, Preshaw PM et al. Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J Periodont Res 2009;44:368-377.
36. Giannopoulou C, Demeurisse C, Cimasoni G. Elastase release from gingival crevicular and peripheral neutrophils in periodontitis and health. Arch Oral Biol 1994;39:741-745.
37. Guyot N, Butler MW, McNally P et al. Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis. J Biol Chem 2008;283:32377-32385.
38. Joseph T, Look D, Ferkol T. NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 2005;288:L471-L479.
39. Kato H. Expression and function of squamous cell carcinoma antigen. Anticancer Res 1996;16:2149-2153.
40. Katagiri C, Nakanishi J, Kadoya K, Hibino T. Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. J Cell Biol 2006;172:983-990.
41. Katagiri C, Iida T, Nakanishi J, Ozawa M, Aiba S, Hibino T. Up-regulation of serpin SCCA1 is associated with epidermal barrier disruption. J Dermatol Sci 2010;57:95-101.
42. Mitsuishi K, Nakamura T, Sakata Y et al. The squamous cell carcinoma antigens as relevant biomarkers of atopic dermatitis. Clin Exp Allergy 2005;35:1327-1333.
43. Yuyama N, Davies DE, Akaiwa M et al. Analysis of novel disease-related genes in bronchial asthma. Cytokine 2002;19:287-296.
44. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Type 1/Type 2 cytokine productionby CD4+ T cellsin adult periodontitis. J Dent Res 1994;74:204.
45. Uemura Y, Pak SC, Luke C et al. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Int J Cancer 2000;89:368-377.