Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production

Biotechnology and Bioengineering

Volumn 109, Issue 4, 2012, Pages 962-970

  Dizon Maspat, Jemelle ^a,b   Bourret, Justin ^a   D'Agostini, Anna ^a,b   Li, Feng ^a,c  

^a GENENTECH INC   (United States)

^b Gilead Inc   (United States)

^c Beijing Mab Works Inc   (China)

Author keywords

Antibody purification; Concentration factor; Process debottleneck; Single pass TFF (SPTFF); Tangential flow filtration (TFF); Ultrafiltration

Indexed keywords

ANTIBODY PURIFICATION; CONCENTRATION FACTOR; PROCESS DEBOTTLENECK; SINGLE PASS; TANGENTIAL FLOW;

CELL CULTURE; LAKES; MANUFACTURE; MONOCLONAL ANTIBODIES; PURIFICATION; ULTRAFILTRATION;

STEADY FLOW;

MONOCLONAL ANTIBODY;

ANTIBODY PRODUCTION; ARTICLE; DOWNSTREAM PROCESSING; FILTRATION; IMMUNOGLOBULIN PURIFICATION; PROCESS CONTROL; PURIFICATION; QUALITY CONTROL; SINGLE PASS TANGENTIAL FLOW FILTRATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; EQUIPMENT DESIGN; FILTRATION; NEPHELOMETRY AND TURBIDIMETRY; OSMOLAR CONCENTRATION; PRESSURE; RECOMBINANT FUSION PROTEINS; RHEOLOGY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84857442266     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24377     Document Type: Article

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