Hemolysis is a major cause of variability in insulin measurement during oral glucose tolerance test in children

Clinical Laboratory

Volumn 58, Issue 1-2, 2012, Pages 67-74

  Bellomo, Giorgio ^a,b   Sulas, Maria Giovanna ^b   Mairate, Elisabetta ^b   Bardone, Maria Beatrice ^b   Rolla, Roberta ^a,b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b Maggiore Delta Carità Hospital   (Italy)

Author keywords

Growth hormone deficiency; Hemolysis; Insulin assay; Oral glucose tolerance test

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GROWTH HORMONE DEFICIENCY; HEMOLYSIS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST;

ADOLESCENT; BLOOD GLUCOSE; DIAGNOSTIC ERRORS; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; GROWTH DISORDERS; HEMOLYSIS; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS;

EID: 84857437444     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Reaven GM, Brand RJ, Chen YD, Mathur AK, Goldfine I. Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes 1993;42:1324-32. (Pubitemid 23259853)
2. Huang XH, Rantalaiho V, Wirta O, et al. Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NlDDM. Hum Genet 1998;102:372-8. (Pubitemid 28185230)
3. Matsui H, Hashimoto H, Fukushima A, et al. MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase. Am Heart J 1996;131:24-31. (Pubitemid 26021360)
4. Giorda C, Appendino M. Effects of doxazosin, a selective alpha 1-inhibitor, on plasma insulin and blood glucose response to a glucose tolerance test in essential hypertension. Metabolism 1993;42:1440-2. (Pubitemid 23335877)
5. Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H. A prospective analysis of the HOMA model: the Mexico City Diabetes Study. Diabetes Care 1996;19:1138-41. (Pubitemid 26334266)
6. Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart Study. Diabetes Care 1997;20:1087-92. (Pubitemid 27274268)
7. World Health Organization: WHO Expert Committee on Diabetes Mellitus. Second Report. Geneva, World Health Org 1980;646:1-80.
8. Ali O, Wyatt D. Therapy of growth disorders. Source Current Opinion in Endocrinology, Diabetes & Obesity 2011;18(1):3-8.
9. Rosenfeld RG. IGF-I therapy in growth disorders. Eur J Endocrinol 2007;157(S1):S57-S60. (Pubitemid 47439669)
10. Chevenne D, Letailleur A, Trivin F, Porquet D. Effect of hemolysis on the concentration of insulin in serum determined by RIA and IRMA. Clin Chem 1998;44(2):354-6. (Pubitemid 28087741)
11. El Kenz H, Bergmann P. Evaluation of immunochemiluminometric assays for the measurement of insulin and C-peptide using the ADVlA Centaur. Clin Lab 2004;50(3-4):171-4. (Pubitemid 38477541)
12. Lippi G, Salvagno GL, Montagnana M, Brocco G, Guidi GC. Influence of hemolysis on routine clinical chemistry testing. Clin Chem Lab Med 2006;44(3):311-6. (Pubitemid 43357691)
13. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Interference of blood cell lysis on routine coagulation testing. Arch Pathol Lab Med 2006;130(2):181-4. (Pubitemid 43237986)
14. Clinical and Laboratory Standards Institute. Collection, transport, and processing of blood specimens for coagulation testing and general performance of coagulation assays. Approved guideline H21-A4, 3rd ed. Wayne, PA: National Committee for Clinical Laboratory Standards, 2003.
15. Salvagno GL, Lippi G, Bassi A, PoIi G, Guidi GC. Prevalence and type of pre-analytical problems for inpatients samples in coagulation laboratory. J Eval Clin Pract 2008;14(2):351-3. (Pubitemid 351347714)
16. Duckworth WC. Insulin degradation: mechanisms, products and significance. Endocr Rev 1988;9:319-45.
17. Authier F, Posner BI, Bergeron JJM. Insulin-degrading enzyme. Clin Invest Med 1996;19:149-60. (Pubitemid 26225900)
18. Shii K, Yokono K, Baba S, Roth RA. Purification and characterization of insulin-degrading enzyme from human erythrocytes. Diabetes 1986;35:675-83. (Pubitemid 16088345)
19. Jung CH, Thomas JA. S-glutathiolated hepatocyte proteins and insulin disulfides as substrates for reduction by glutaredoxin, thioredoxin, protein disulfide isomerase, and glutathione. Arch Biochem Biophys 1996;335(1):61-72. (Pubitemid 26382679)
20. Ansorge S, Bohley P, Kirschke H, Langner J, Wiederanders B. The insulin and glucagon degrading proteinase of rat liver: a metal-dependent enzyme. Biomed Biochim Acta 1984;43(1):39-46. (Pubitemid 14105984)
21. Pasic J, Bhatnagar MK, Pickup JC. Self-collection by diabetic patients of capillary blood for free insulin monitoring; reduction by diamide of haemolysis-induced insulin loss. Diabet Med 1991;8(2):140-5.
22. Sapin R, Ongagna JC, Gasser F, Grucker D. Insulin measurements in haemolysed serum: influence of insulinase inhibitors. ClinChim Acta. 1998;274(1):111-7. (Pubitemid 28243268)