Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages 3119-3124

  Lopes, Rita ^a   Van Wijk, Nicole Verhey ^a   Neves, Guilherme ^a   Pachnis, Vassilis ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Medial ganglionic eminence derived interneurons; Neuronal subtype specification

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BIOLOGICAL MARKER; CHOLINE ACETYLTRANSFERASE; HOMEODOMAIN PROTEIN; LIM PROTEIN; PROTEIN; PROTEIN ISL1; TRANSCRIPTION FACTOR LHX6; TRANSCRIPTION FACTOR LHX7; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL DIVISION; CELL LINEAGE; CELL MATURATION; CELL STRUCTURE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; INTERNEURON; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

EID: 84857428647     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1109251109     Document Type: Article

References (39)

1. Flames N, et al. (2007) Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci 27:9682-9695. (Pubitemid 47492179)
2. Guillemot F (2007) Cell fate specification in the mammalian telencephalon. Prog Neurobiol 83:37-52.
3. Shirasaki R, Pfaff SL (2002) Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci 25:251-281. (Pubitemid 34748018)
4. Zhou FM, Wilson CJ, Dani JA (2002) Cholinergic interneuron characteristics and nicotinic properties in the striatum. J Neurobiol 53:590-605. (Pubitemid 35375589)
5. Bolam JP, Hanley JJ, Booth PA, Bevan MD (2000) Synaptic organisation of the basal ganglia. J Anat 196:527-542. (Pubitemid 30458775)
6. Marin O, Anderson SA, Rubenstein JL (2000) Origin and molecular specification of striatal interneurons. J Neurosci 20:6063-6076. (Pubitemid 30658400)
7. Nóbrega-Pereira S, et al. (2008) Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors. Neuron 59:733-745.
8. Fragkouli A, van Wijk NV, Lopes R, Kessaris N, Pachnis V (2009) LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development 136:3841-3851.
9. Flames N, Marín O (2005) Developmental mechanisms underlying the generation of cortical interneuron diversity. Neuron 46:377-381. (Pubitemid 40616879)
10. Liodis P, et al. (2007) Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27:3078-3089. (Pubitemid 46474122)
11. Elshatory Y, Gan L (2008) The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci 28:3291-3297. (Pubitemid 351469309)
12. Fragkouli A, et al. (2005) Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci 21:2923-2938. (Pubitemid 40917057)
13. Mori T, et al. (2004) The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci 19:3129-3141. (Pubitemid 38859530)
14. Zhao Y, et al. (2003) The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in themouse forebrain. Proc Natl Acad Sci USA 100:9005-9010. (Pubitemid 36899213)
15. Lewandoski M, Meyers EN, Martin GR (1997) Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb Symp Quant Biol 62:159-168. (Pubitemid 28198533)
16. Gong S, et al. (2007) Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J Neurosci 27:9817-9823. (Pubitemid 47403991)
17. Srinivas S, et al. (2001) Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1:4.
18. Phelps PE, Brady DR, Vaughn JE (1989) The generation and differentiation of cholinergic neurons in rat caudate-putamen. Brain Res Dev Brain Res 46:47-60. (Pubitemid 19061063)
19. Arvidsson U, Riedl M, Elde R, Meister B (1997) Vesicular acetylcholine transporter (VAChT) protein: A novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. J Comp Neurol 378:454-467. (Pubitemid 27061448)
20. Sobreviela T, et al. (1994) TrkA-immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. J Comp Neurol 350:587-611. (Pubitemid 24372037)
21. Kawaguchi Y (1997) Neostriatal cell subtypes and their functional roles. Neurosci Res 27:1-8.
22. Matamales M, et al. (2009) Striatal medium-sized spiny neurons: Identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice. PLoS ONE 4:e4770.
23. Hobert O (2008) Regulatory logic of neuronal diversity: Terminal selector genes and selector motifs. Proc Natl Acad Sci USA 105:20067-20071.
24. Cheng L, et al. (2004) Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci 7:510-517. (Pubitemid 38544590)
25. Nakatani T, Minaki Y, Kumai M, Ono Y (2007) Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development 134:2783-2793. (Pubitemid 47305053)
26. Sieber MA, et al. (2007) Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons inthe hindbrain. JNeurosci 27:4902-4909. (Pubitemid 46699056)
27. AzimE, JabaudonD, FameRM,Macklis JD (2009) SOX6controlsdorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci 12:1238-1247.
28. Batista-Brito R, et al. (2009) The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron 63:466-481.
29. Bolam JP, Wainer BH, Smith AD (1984) Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy. Neuroscience 12:711-718. (Pubitemid 14092487)
30. Haas CA, et al. (1998) Axotomy-induced c-JUN expression in young medial septal neurons is regulated by nerve growth factor. Neuroscience 87:831-844. (Pubitemid 28400354)
31. Lazo OM, Mauna JC, Pissani CA, Inestrosa NC, Bronfman FC (2010) Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Mol Neurodegener 5:5.
32. Altar CA, et al. (1992) Recovery of cholinergic phenotype in the injured rat neostriatum: Roles for endogenous and exogenous nerve growth factor. J Neurochem59:2167-2177.
33. Gage FH, et al. (1989) NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum. Neuron 2:1177-1184.
34. Förander P, Söderström S, Humpel C, Strömberg I (1996) Chronic infusion of nerve growth factor into rat striatum increases cholinergic markers and inhibits striatal neuronal discharge rate. Eur J Neurosci 8:1822-1832.
35. Graf T, Enver T (2009) Forcing cells to change lineages. Nature 462:587-594.
36. Cobaleda C, Jochum W, Busslinger M (2007) Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449:473-477. (Pubitemid 47509547)
37. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455:627-632.
38. Schaeren-Wiemers N, Gerfin-Moser A (1993) A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100:431-440. (Pubitemid 24049312)
39. Heng JI, et al. (2008) Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature 455:114-118.