Subthreshold symptoms in bipolar disorder: Impact on neurocognition, quality of life and disability

Journal of Affective Disorders

Volumn 136, Issue 3, 2012, Pages 650-659

  Bonnin C M ^a   Sanchez Moreno J ^a   Martinez Aran A ^a   Sole B ^a   Reinares, M ^a   Rosa, A R ^a   Goikolea, J M ^a   Benabarre, A ^a   Ayuso Mateos, J L ^b   Ferrer, M ^c,d   Vieta, E ^a   Torrent, C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

Author keywords

Bipolar; Functioning; Neurocognition; Subthreshold symptomatology

Indexed keywords

LITHIUM; NEUROLEPTIC AGENT;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL ASSESSMENT TOOL; COGNITION; COMPREHENSION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE COURSE; EMPLOYMENT STATUS; EXECUTIVE FUNCTION; FEMALE; HAMILTON SCALE; HOSPITALIZATION; HUMAN; HUMAN RELATION; INTERPERSONAL COMMUNICATION; MAJOR CLINICAL STUDY; MALE; MANIA; PRIORITY JOURNAL; QUALITY OF LIFE; RECALL; SELF CARE; SHORT FORM 36; SOCIAL PSYCHOLOGY; WORLD HEALTH ORGANIZATION DISABILITY ASSESSMENT SCHEDULE 2; YOUNG MANIA RATING SCALE;

ACTIVITIES OF DAILY LIVING; ADULT; BIPOLAR DISORDER; COGNITION; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PSYCHOLOGY; QUALITY OF LIFE;

EID: 84857373626     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.10.012     Document Type: Article

References (83)

1. J. Alonso, L. Prieto, and J.M. Anto The Spanish version of the SF-36 Health Survey (the SF-36 health questionnaire): an instrument for measuring clinical results Medical Clinic (Barcelona) 104 1995 771 776
2. Alonso, J.; Petukhova, M.; Vilagut, G.; Chatterji, S.; Heeringa, S.; Ustün, T.B.; Alhamzawi, A.O.; Viana, M.C.; Angermeyer, M.; Bromet, E.; Bruffaerts, R.; de Girolamo, G.; Florescu, S.; Gureje, O.; Haro, J.M.; Hinkov, H.; Hu, C.Y.; Karam, E.G.; Kovess, V.; Levinson, D.; Medina-Mora, M.E.; Nakamura, Y.; Ormel, J.; Posada-Villa, J.; Sagar, R.; Scott, K.M.; Tsang, A.; Williams, D.R.; Kessler, R.C.; in press. Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys. Molecular Psychiatry.
3. L.L. Altshuler, M.J. Gitlin, J. Mintz, K.L. Leight, and M.A. Frye Subsyndromal depression is associated with functional impairment in patients with bipolar disorder The Journal of Clinical Psychiatry 63 2002 807 811
4. L.L. Altshuler, R.M. Post, D.O. Black, P.E. Keck Jr.; W.A. Nolen, M.A. Frye, T. Suppes, H. Grunze, R.W. Kupka, G.S. Leverich, S.L. McElroy, J. Walden, and J. Mintz Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study The Journal of Clinical Psychiatry 67 2006 1551 1560
5. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. DSM-IV 4th ed. 1994 APA Washington,DC
6. V. Balanza-Martinez, G. Selva, A. Martinez-Aran, J. Prickaerts, J. Salazar, A. Gonzalez-Pinto, E. Vieta, and R. Tabares-Seisdedos Neurocognition in bipolar disorders-a closer look at comorbidities and medications European Journal of Pharmacology 626 2010 87 96
7. A.L. Benton, K.deS. Hamsher, and A.B. Sivan Multilingual Aphasia Examination 3rd ed. 1994 AJA Associates, Inc. Iowa City
8. M. Berk, F. Ng, W.V. Wang, J.R. Calabrese, P.B. Mitchell, G.S. Malhi, and M. Tohen The empirical redefinition of the psychometric criteria for remission in bipolar disorder Journal of Affective Disorders 106 2008 153 158
9. C.M. Bonnin, A. Martinez-Aran, C. Torrent, I. Pacchiarotti, A.R. Rosa, C. Franco, A. Murru, J. Sanchez-Moreno, and E. Vieta Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study Journal of Affective Disorders 121 2010 156 160
10. S.E. Buffett-Jerrott, and S.H. Stewart Cognitive and sedative effects of benzodiazepine use Current Pharmaceutical Design 8 2002 45 58
11. K.E. Burdick, J.F. Goldberg, and M. Harrow Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up Acta Psychiatrica Scandinavica 122 2010 499 506
12. J.R. Calabrese, R.M. Hirschfeld, M.A. Frye, and M.L. Reed Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample The Journal of Clinical Psychiatry 65 2004 1499 1504
13. K.N. Chengappa, R.W. Baker, L. Shao, L.N. Yatham, M. Tohen, S. Gershon, and D.J. Kupfer Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania Bipolar Disorders 5 2003 1 5
14. F. Colom, E. Vieta, A. Martinez-Aran, M. Garcia-Garcia, M. Reinares, C. Torrent, J.M. Goikolea, S. Banus, and M. Salamero Spanish version of a scale for the assessment of mania: validity and reliability of the Young Mania Rating Scale Medical Clinic (Barcelona) 119 2002 366 371
15. M.P. Delbello, D. Hanseman, C.M. Adler, D.E. Fleck, and S.M. Strakowski Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode The American Journal of Psychiatry 164 2007 582 590
16. D.C. Delis, J.H. Kramer, E. Kaplan, and B. Ober California Verbal Learning Test Psychological Corporation, New York 1987
17. C.A. Depp, H. Jin, S. Mohamed, J. Kaskow, D.J. Moore, and D.V. Jeste Bipolar disorder in middle-aged and elderly adults: is age of onset important? The Journal of Nervous and Mental Disease 192 2004 796 799
18. M. Doyle, S. Flanagan, S. Browne, M. Clarke, D. Lydon, C. Larkin, and E. O'Callaghan Subjective and external assessments of quality of life in schizophrenia: relationship to insight Acta Psychiatrica Scandinavica 99 1999 466 472
19. H.H. Elshahawi, H. Essawi, M.A. Rabie, M. Mansour, Z.A. Beshry, and A.N. Mansour Cognitive functions among euthymic bipolar I patients after a single manic episode versus recurrent episodes Journal of Affective Disorders 130 2011 180 191
20. A. Ertugrul, and B. Ulug The influence of neurocognitive deficits and symptoms on disability in schizophrenia Acta Psychiatrica Scandinavica 105 2002 196 201
21. I.N. Ferrier, and J.M. Thompson Cognitive impairment in bipolar affective disorder: implications for the bipolar diathesis The British Journal of Psychiatry 180 2002 293 295
22. I.N. Ferrier, B.R. Stanton, T.P. Kelly, and J. Scott Neuropsychological function in euthymic patients with bipolar disorder The British Journal of Psychiatry 175 1999 246 251
23. M.A. Frye, L.N. Yatham, J.R. Calabrese, C.L. Bowden, T.A. Ketter, T. Suppes, B.E. Adams, and T.R. Thompson Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials The Journal of Clinical Psychiatry 67 2006 1721 1728
24. Garin O.; yuso-Mateos J.L.; Almansa J.; Nieto M.; Chatterji S.; G. Vilagut, Alonso J.; Cieza A.; Svetskova O.; Burger H.; Racca V.; Francescutti C.; Vieta E.; Kostanjsek N.; Raggi A.; Leonardi M.; and Ferrer M. Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases Health and Quality of Life Outcomes 8 2010 51
25. Goetz I.; Tohen M.; Reed C.; Lorenzo M.; Vieta E.; and EMBLEM Advisory Board Functional impairment in patients with mania: baseline results of the EMBLEM study Bipolar Disorders 9 2007 45 52
26. Golden C.J. Stroop Colour and Word Test Stoelting, Chicago 1978
27. G.M. Goodwin, A. Martinez-Aran, D.C. Glahn, and E. Vieta Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report European Neuropsychopharmacology 18 2008 787 793
28. L. Gutierrez-Rojas, Gurpegui M.; yuso-Mateos J.L.; Gutierrez-Ariza J.A.; Ruiz-Veguilla M.; and Jurado D. Quality of life in bipolar disorder patients: a comparison with a general population sample Bipolar Disorders 10 2008 625 634
29. L. Gutierrez-Rojas, D. Jurado, and M. Gurpegui Factors associated with work, social life and family life disability in bipolar disorder patients Psychiatry Research 186 2011 254 260
30. M. Hamilton A rating scale for depression Journal of Neurology, Neurosurgery, and Psychiatry 23 1960 56 62
31. C. Hammen, M. Gitlin, and L. Altshuler Predictors of work adjustment in bipolar I patients: a naturalistic longitudinal follow-up Journal of Consulting and Clinical Psychology 68 2000 220 225
32. M. Harrow, J.F. Goldberg, L.S. Grossman, and H.Y. Meltzer Outcome in manic disorders. A naturalistic follow-up study Archives of General Psychiatry 47 1990 665 671
33. R.K. Heaton Wisconsin Card Sorting Test Manual Psychological Assessment Resources, Odessa, Florida 1981
34. L.L. Judd, and H.S. Akiskal Depressive episodes and symptoms dominate the longitudinal course of bipolar disorder Current Psychiatry Reports 5 2003 417 418
35. L.E. Kazis, J.J. Anderson, and R.F. Meenan Effect sizes for interpreting changes in health status Medical Care 27 1989 S178 S189
36. K.E. Lewandowski, B.M. Cohen, and D. Öngur Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder Psychological Medicine 41 2011 225 241
37. G.M. MacQueen, L.T. Young, J.C. Robb, M. Marriott, R.G. Cooke, and R.T. Joffe Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder Acta Psychiatrica Scandinavica 101 2000 374 381
38. G.M. MacQueen, L.T. Young, and R.T. Joffe A review of psychosocial outcome in patients with bipolar disorder Acta Psychiatrica Scandinavica 103 2001 163 170
39. G.M. MacQueen, M. Marriott, H. Begin, J. Robb, R.T. Joffe, and L.T. Young Subsyndromal symptoms assessed in longitudinal, prospective follow-up of a cohort of patients with bipolar disorder Bipolar Disorders 5 2003 349 355
40. L.B. Marangell, E.B. Dennehy, S. Miyahara, S.R. Wisniewski, M.S. Bauer, M.H. Rapaport, and M.H. Allen The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD Journal of Affective Disorders 114 2009 58 67
41. A. Martinez-Aran, E. Vieta, F. Colom, C. Torrent, J. Sanchez-Moreno, M. Reinares, A. Benabarre, J.M. Goikolea, E. Brugue, C. Daban, and M. Salamero Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome Bipolar Disorders 6 2004 224 232
42. A. Martinez-Aran, E. Vieta, M. Reinares, F. Colom, C. Torrent, J. Sanchez-Moreno, A. Benabarre, J.M. Goikolea, M. Comes, and M. Salamero Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder The American Journal of Psychiatry 161 2004 262 270
43. A. Martinez-Aran, E. Vieta, F. Colom, C. Torrent, M. Reinares, J.M. Goikolea, A. Benabarre, M. Comes, and J. Sanchez-Moreno Do cognitive complaints in euthymic bipolar patients reflect objective cognitive impairment? Psychotherapy and Psychosomatics 74 2005 295 302
44. Martinez-Aran A.; Vieta E.; Torrent C.; Sanchez-Moreno J.; Goikolea J.M.; Salamero M.; Malhi G.S.; Gonzalez-Pinto A.; Daban C.; varez-Grandi S.; Fountoulakis K.; Kaprinis G.; Tabares-Seisdedos R.; and Ayuso-Mateos J.L. Functional outcome in bipolar disorder: the role of clinical and cognitive factors Bipolar Disorders 9 2007 103 113
45. A. Martinez-Aran, C. Torrent, R. Tabares-Seisdedos, M. Salamero, C. Daban, V. Balanza-Martinez, J. Sanchez-Moreno, G.J. Manuel, A. Benabarre, F. Colom, and E. Vieta Neurocognitive impairment in bipolar patients with and without history of psychosis The Journal of Clinical Psychiatry 69 2008 233 239
46. B.T. Mausbach, P.D. Harvey, S.R. Goldman, D.V. Jeste, and T.L. Patterson Development of a brief scale of everyday functioning in persons with serious mental illness Schizophrenia Bulletin 33 2007 1364 1372
47. C. McKibbin, T.L. Patterson, and D.V. Jeste Assessing disability in older patients with schizophrenia: results from the WHODAS-II The Journal of Nervous and Mental Disease 192 2004 405 413
48. K.R. Merikangas, H.S. Akiskal, J. Angst, P.E. Greenberg, R.M. Hirschfeld, M. Petukhova, and R.C. Kessler Lifetime and 12-month prevalence of bipolar spectrum disorder in the national comorbidity survey replication Archives of General Psychiatry 64 2007 543 552
49. E.E. Michalak, and G. Murray Development of the QoL.BD: a disorder-specific scale to assess quality of life in bipolar disorder Bipolar Disorders 12 2010 727 740
50. E.E. Michalak, L.N. Yatham, and R.W. Lam Quality of life in bipolar disorder: A review of the literature Health and Quality of Life Outcomes 3 2005 72
51. M. Mur, M.J. Portella, A. Martinez-Aran, J. Pifarre, and E. Vieta Persistent neuropsychological deficit in euthymic bipolar patients: executive function as a core deficit The Journal of Clinical Psychiatry 68 2007 1078 1086
52. C.J. Murray, and A.D. Lopez Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study Lancet 349 1997 1498 1504
53. J.A. Ramos-Brieva, and A. Cordero-Villafafila A new validation of the Hamilton Rating Scale for Depression Journal of Psychiatric Research 22 1988 21 28
54. R.M. Reitan Validity of the Trailmaking Test as a indication of organic brain damage Perceptual and Motor Skills 8 1958 271 276
55. A. Rey L'examen psychologique dans les cas d'encephalophatie traumatique Archives de Psychologie 28 1941 286 340
56. A. Rey Test de copia y reproduccion de memoria de una figura geometrica compleja 1999 TEA Madrid
57. L.J. Robinson, J.M. Thompson, P. Gallagher, U. Goswami, A.H. Young, I.N. Ferrier, and P.B. Moore A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder Journal of Affective Disorders 93 2006 105 115
58. S.E. Romans, and H.M. McPherson The social networks of bipolar affective disorder patients Journal of Affective Disorders 25 1992 221 228
59. Rosa A.R.; Sanchez-Moreno J.; Martinez-Aran A.; Salamero M.; Torrent C.; Reinares M.; M. Comes, Colom F.; Van R.W.; yuso-Mateos J.L.; Kapczinski F.; and Vieta E. Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder Clinical Practice Epidemiology Mental Health 3 2007 5
60. A.R. Rosa, C. Franco, A. Martinez-Aran, J. Sanchez-Moreno, M. Reinares, M. Salamero, C. Arango, J.L. Ayuso-Mateos, F. Kapczinski, and E. Vieta Functional impairment in patients with remitted bipolar disorder Psychotherapy and Psychosomatics 77 2008 390 392
61. Rosa A.R.; Bonnin C.M.; Mazzarini L.; Amann B.; Kapczinski F.; and Vieta E. Predictores clínicos del funcionamiento interpersonal en pacientes bipolares Revista de Psiquiatría y Salud Mental 02 2009 83 88
62. A.R. Rosa, M. Reinares, C. Franco, M. Comes, C. Torrent, J. Sanchez-Moreno, A. Martinez-Aran, M. Salamero, F. Kapczinski, and E. Vieta Clinical predictors of functional outcome of bipolar patients in remission Bipolar Disorders 11 2009 401 409
63. A.R. Rosa, C.M. Bonnin, G.H. Vazquez, M. Reinares, B. Sole, R. Tabares-Seisdedos, V. Balanza-Martinez, A. Gonzalez-Pinto, J. Sanchez-Moreno, and E. Vieta Functional impairment in bipolar II disorder: Is it as disabling as bipolar I? Journal of Affective Disorders 127 2010 71 76
64. J. Sanchez-Moreno, A. Martinez-Aran, R. Tabares-Seisdedos, C. Torrent, E. Vieta, and J.L. Ayuso-Mateos Functioning and disability in bipolar disorder: an extensive review Psychotherapy and Psychosomatics 78 2009 285 297
65. G.E. Simon, M.S. Bauer, E.J. Ludman, B.H. Operskalski, and J. Unutzer Mood symptoms, functional impairment, and disability in people with bipolar disorder: specific effects of mania and depression The Journal of Clinical Psychiatry 68 2007 1237 1245
66. M.K. Spearing, R.M. Post, G.S. Leverich, D. Brandt, and W. Nolen Modification of the Clinical Global Impressions (CGI) Scale for use in bipolar illness (BP): the CGI-BP Psychiatry Research 73 1997 159 171
67. M. Tohen, T.G. Jacobs, S.L. Grundy, S.L. McElroy, M.C. Banov, P.G. Janicak, T. Sanger, R. Risser, F. Zhang, V. Toma, J. Francis, G.D. Tollefson, and A. Breier Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group Archives of General Psychiatry 57 2000 841 849
68. M. Tohen, W. Greil, J.R. Calabrese, G.S. Sachs, L.N. Yatham, B.M. Oerlinghausen, A. Koukopoulos, G.B. Cassano, H. Grunze, R.W. Licht, L. Dell'Osso, A.R. Evans, R. Risser, R.W. Baker, H. Crane, M.R. Dossenbach, and C.L. Bowden Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial The American Journal of Psychiatry 162 2005 1281 1290
69. M. Tohen, C.L. Bowden, J.R. Calabrese, D. Lin, T.D. Forrester, G.S. Sachs, A. Koukopoulos, L. Yatham, and H. Grunze Influence of sub-syndromal symptoms after remission from manic or mixed episodes The British Journal of Psychiatry 189 2006 515 519
70. C. Torrent, A. Martinez-Aran, C. Daban, J. Sanchez-Moreno, M. Comes, J.M. Goikolea, M. Salamero, and E. Vieta Cognitive impairment in bipolar II disorder The British Journal of Psychiatry 189 2006 254 259
71. Torres I.J.; Boudreau V.G.; and Yatham L.N. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis Acta Psychiatrica Scandinavica. Supplementum 2007 17 26
72. I.J. Torres, V.G. DeFreitas, C.M. DeFreitas, M. Kauer-Sant'anna, D.J. Bond, W.G. Honer, R.W. Lam, and L.N. Yatham Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode The Journal of Clinical Psychiatry 71 2010 1234 1242
73. E. Vieta The influence of medications on neurocognition in bipolar disorder Acta Psychiatrica Scandinavica 120 2009 414 415
74. E. Vieta Bipolar Units and Programmes: Are they really needed? World Psychiatry 10 2011 152
75. E. Vieta Tertiarism in Psychiatry: The Barcelona "Clinic" Bipolar Disorders Programme Revista de Psiquiatría y Salud Mental (Barcelona) 4 2011 1 4
76. Vieta E.; R. de Arce, Jimenez-Arriero M.A.; Rodriguez A.; Balanza V.; and Cobaleda S. Detection of subclinical depression in bipolar disorder: a cross-sectional, 4-month prospective follow-up study at community mental health services (SIN-DEPRES) The Journal of Clinical Psychiatry 71 2010 1465 1474
77. L.M. Weinstock, and I.W. Miller Psychosocial predictors of mood symptoms 1 year after acute phase treatment of bipolar I disorder Comprehensive Psychiatry 51 2010 497 503
78. D. Weschler Weschler Memory Scale third ed. 1997
79. D. Weschler The Wechsler Adult Intelligence Scale -III (WAIS-III) 1997
80. A.P. Wingo, P.D. Harvey, and R.J. Baldessarini Neurocognitive impairment in bipolar disorder patients: functional implications Bipolar Disorders 11 2009 113 125
81. L.N. Yatham, I.J. Torres, G.S. Malhi, S. Frangou, D.C. Glahn, C.E. Bearden, K.E. Burdick, A. Martinez-Aran, S. Dittmann, J.F. Goldberg, A. Ozerdem, O. Aydemir, and K.N. Chengappa The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC) Bipolar Disorders 12 2010 351 363
82. R.C. Young, J.T. Biggs, V.E. Ziegler, and D.A. Meyer A rating scale for mania: reliability, validity and sensitivity The British Journal of Psychiatry 133 1978 429 435
83. J.K. Zubieta, P. Huguelet, R.L. O'Neil, and B.J. Giordani Cognitive function in euthymic bipolar I disorder Psychiatry Research 102 2001 9 20