QCT-based finite element models predict human vertebral strength in vitro significantly better than simulated DEXA

Osteoporosis International

Volumn 23, Issue 2, 2012, Pages 563-572

  Dall'Ara, E ^a   Pahr, D ^a   Varga, P ^a   Kainberger, F ^b   Zysset, P ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bone mineral density; Bone strength; DXA; Finite element modeling; Mechanical testing; Osteoporosis

Indexed keywords

ADULT; AGED; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MINERAL; BONE STRENGTH; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IN VITRO STUDY; MALE; MATHEMATICAL MODEL; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE COMPUTED TOMOGRAPHY; RADIATION DOSE; RIGIDITY; RISK ASSESSMENT; SIMULATION; VERTEBRA; VERTEBRA FRACTURE; YOUNG MODULUS;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; AGED, 80 AND OVER; BIOMECHANICS; BONE DENSITY; FEMALE; FINITE ELEMENT ANALYSIS; HUMANS; MALE; MIDDLE AGED; OSTEOPOROTIC FRACTURES; SPINAL FRACTURES; SPINE; STRESS, MECHANICAL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84857372038     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-011-1568-3     Document Type: Article

References (59)

1. O Johnell JA Kanis 2006 An estimate of the worldwide prevalence and disability associated with osteoporotic fractures Osteoporos Int 17 1726 1733 16983459 10.1007/s00198-006-0172-4 1:STN:280:DC%2BD28nitVSksQ%3D%3D
2. O Johnell J Kanis 2005 Epidemiology of osteoporotic fractures Osteoporos Int 16 Suppl 2 S3 S7 15365697 10.1007/s00198-004-1702-6
3. T Jalava, et al. 2003 Association between vertebral fracture and increased mortality in osteoporotic patients J Bone Miner Res 18 1254 1260 12854835 10.1359/jbmr.2003.18.7.1254
4. JA Kanis A Oden O Johnell C De Laet B Jonsson 2004 Excess mortality after hospitalisation for vertebral fracture Osteoporos Int 15 108 112 14598026 10.1007/s00198-003-1516-y
5. World Health Organisation. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis, Technical Report Series, vol. 843, 1994, WHO, Geneve.
6. JA Kanis CC Gluer 2000 An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation Osteoporos Int 11 192 202 10824234 10.1007/s001980050281 1:STN:280:DC%2BD3c3osVanug%3D%3D
7. D Marshall O Johnell H Wedel 1996 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures BMJ 312 1254 1259 8634613 10.1136/bmj.312.7041.1254 1:STN:280:DyaK283isFejtw%3D%3D
8. JA Kanis, et al. 2006 The use of multiple sites for the diagnosis of osteoporosis Osteoporos Int 17 527 534 16402164 10.1007/s00198-005-0014-9 1:STN:280:DC%2BD287msF2msQ%3D%3D
9. JF Griffith HK Genant 2008 Bone mass and architecture determination: state of the art Best Pract Res Clin Endocrinol Metab 22 737 764 19028355 10.1016/j.beem.2008.07.003
10. C Bergot AM Laval-Jeantet K Hutchinson I Dautraix F Caulin HK Genant 2001 A comparison of spinal quantitative computed tomography with dual energy X-ray absorptiometry in European women with vertebral and nonvertebral fractures Calcif Tissue Int 68 74 82 11310350 10.1007/BF02678144 1:CAS:528: DC%2BD3MXkvFeku7Y%3D
11. JF Griffith K Engelke HK Genant 2010 Looking beyond bone mineral density: imaging assessment of bone quality Ann NY Acad Sci 1192 45 56 20392217 10.1111/j.1749-6632.2009.05378.x
12. J Roux J Wegrzyn M Arlot O Guyen P Delmas R Chapurlat M Bouxsein 2009 Contribution of trabecular and cortical components to biomechanical behavior of human vertebrae: an ex-vivo study J Bone Miner Res 25 2 356 361 10.1359/jbmr.090803
13. ES Siris YT Chen TA Abbott E Barrett-Connor PD Miller LE Wehren ML Berger 2004 Bone mineral density thresholds for pharmacological intervention to prevent fractures Arch Intern Med 164 1108 1112 15159268 10.1001/archinte.164. 10.1108
14. Hayes WC (1991) Biomechanics of cortical and trabecular bone: Implications for assessment of fracture risk. In: Hayes, WC (ed) Basic orthopaedics biomechanics, Raven press, pp. 93-142.
15. MJ Silva 2007 Biomechanics of osteoporotic fractures Injury 38 Suppl 3 S69 S76 17723795 10.1016/j.injury.2007.08.014
16. KS Davison, et al. 2006 Bone strength: the whole is greater than the sum of its parts Semin Arthritis Rheum 36 22 31 16887465 10.1016/j.semarthrit.2006. 04.002
17. P Ammann R Rizzoli 2003 Bone strength and its determinants Osteoporos Int 14 Suppl 3 S13 S18 12730800
18. S Viguet-Carrin P Garnero PD Delmas 2006 The role of collagen in bone strength Osteoporos Int 17 319 336 16341622 10.1007/s00198-005-2035-9 1:CAS:528:DC%2BD28XislCrtro%3D
19. P McDonnell PE McHugh D O'Mahoney 2007 Vertebral osteoporosis and trabecular bone quality Ann Biomed Eng 35 170 189 17171508 10.1007/s10439-006- 9239-9 1:STN:280:DC%2BD2s%2FisVWjtQ%3D%3D
20. ML Bouxsein 2003 Bone quality: where do we go from here? Osteoporos Int 14 Suppl 5 S118 S127 14504716 10.1007/s00198-003-1489-x
21. Augat P, Schorlemmer S (2006) The role of cortical bone and its microstructure in bone strength. Age Ageing 35 Suppl 2: ii27-ii31.
22. XN Dong XE Guo 2004 The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity. 37 8 1281 1287
23. CH Turner 2002 Biomechanics of bone: determinants of skeletal fragility and bone quality Osteoporos Int 13 97 104 11905527 10.1007/s001980200000 1:STN:280:DC%2BD387ntlaguw%3D%3D
24. TE Ciarelli DP Fyhrie MB Schaffler SA Goldstein 2000 Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls J Bone Miner Res 15 32 40 10646112 10.1359/jbmr.2000.15.1.32 1:STN:280:DC%2BD3c7htFGrsw%3D%3D
25. J Homminga B Van-Rietbergen EM Lochmuller H Weinans F Eckstein R Huiskes 2004 The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads Bone 34 510 516 15003798 10.1016/j.bone.2003.12.001 1:STN:280:DC%2BD2c7htlCmsg%3D%3D
26. D Ulrich B van Rietbergen A Laib P Ruegsegger 1999 The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone Bone 25 55 60 10423022 10.1016/S8756-3282(99)00098-8 1:STN:280: DyaK1MzkvFyrtw%3D%3D
27. M Matsuura F Eckstein EM Lochmuller PK Zysset 2007 The role of fabric in the quasi-static compressive mechanical properties of human trabecular bone from various anatomical locations Biomech Model Mechanobiol 19 19
28. TE Wenzel MB Schaffler DP Fyhrie 1996 In vivo trabecular microcracks in human vertebral bone Bone 19 89 95 8853850 10.1016/8756-3282(96)88871-5 1:STN:280:DyaK2s%2Fgs1GmtQ%3D%3D
29. TM Keaveny XE Guo EF Wachtel TA McMahon WC Hayes 1994 Trabecular bone exhibits fully linear elastic behavior and yields at low strains J Biomech 27 1127 1136 7929462 10.1016/0021-9290(94)90053-1 1:STN:280:DyaK2M%2FhsVGqsw%3D%3D
30. GY Boivin PM Chavassieux AC Santora J Yates PJ Meunier 2000 Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women Bone 27 687 694 11062357 10.1016/S8756-3282(00) 00376-8 1:CAS:528:DC%2BD3cXosFygtL8%3D
31. L Rincon-Kohli PK Zysset 2009 Multi-axial mechanical properties of human trabecular bone Biomech Model Mechanobiol 8 195 208 18695984 10.1007/s10237-008-0128-z
32. PK Zysset 2003 A review of morphology-elasticity relationships in human trabecular bone: theories and experiments J Biomech 36 1469 1485 14499296 10.1016/S0021-9290(03)00128-3
33. B Helgason E Perilli E Schileo F Taddei S Brynjolfsson M Viceconti 2008 Mathematical relationships between bone density and mechanical properties: a literature review Clin Biomech (Bristol, Avon) 23 135 146 10.1016/j.clinbiomech. 2007.08.024
34. Zysset PK, Rincon-Kohli L (2006) An alternative fabric-based yield and failure criterion for treabecular bone. In: Holzapfel G, Ogden R (eds) Mechanics of biological tissue. Springer, Berlin, pp 457-470
35. D Garcia PK Zysset M Charlebois A Curnier 2009 A three-dimensional elastic plastic damage constitutive law for bone tissue Biomech Model Mechanobiol 8 149 165 18398628 10.1007/s10237-008-0125-2
36. K Imai I Ohnishi M Bessho K Nakamura 2006 Nonlinear finite element model predicts vertebral bone strength and fracture site Spine 31 1789 1794 16845352 10.1097/01.brs.0000225993.57349.df
37. E Dall'Ara R Schmidt D Pahr P Varga Y Chevalier J Patsch F Kainberger P Zysset 2010 A nonlinear finite element model validation study based on a novel experimental technique for inducing anterior wedge-shape fractures in human vertebral bodies in vitro J Biomech 43 2374 2380 20462582 10.1016/j.jbiomech. 2010.04.023
38. Y Chevalier D Pahr PK Zysset 2009 The role of cortical shell and trabecular fabric in finite element analysis of the human vertebral body J Biomech Eng 131 111003 20353254 10.1115/1.3212097
39. JM Buckley K Loo J Motherway 2007 Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength Bone 40 767 774 17174619 10.1016/j.bone.2006.10.025
40. MJ Silva TM Keaveny WC Hayes 1998 Computed tomography-based finite element analysis predicts failure loads and fracture patterns for vertebral sections J Orthop Res 16 300 308 9671924 10.1002/jor.1100160305 1:STN:280:DyaK1czjsFKntw%3D%3D
41. A Zeinali B Hashemi S Akhlaghpoor 2010 Noninvasive prediction of vertebral body compressive strength using nonlinear finite element method and an image based technique Phys Med 26 88 97 19781969 10.1016/j.ejmp.2009.08.002
42. L Cristofolini E Schileo M Juszczyk F Taddei S Martelli M Viceconti 2010 Mechanical testing of bones: the positive synergy of finite-element models and in vitro experiments Philos Transact A Math Phys Eng Sci 368 2725 2763 20439271 10.1098/rsta.2010.0046
43. SZ Brianza P D'Amelio N Pugno M Delise C Bignardi G Isaia 2007 Allometric scaling and biomechanical behavior of the bone tissue: an experimental intraspecific investigation Bone 40 1635 1642 17400044 10.1016/j.bone.2007.02. 013
44. Mulder L, Van Rietbergen B, Noordhoek N, Ito K (2010) Determination of in-vivo vertebral and femural trabecular morphology and stiffness using a flat-panel CT fluoroscopy approach. 17th congress of the European society of biomechanics, University of Edinburgh, UK, 4-8 July 2010.
45. Pahr D, Dall'Ara E, Varga P, Zysset P (2010) Homogenized continuum-level finite element models predict experimental vertebral stiffness and strength with the same accuracy as μFE models. 17th congress of the European society of biomechanics, University of Edinburgh, UK, 4-8 July 2010.
46. P Varga S Baumbach D Pahr PK Zysset 2009 Validation of an anatomy specific finite element model of Colles' fracture J Biomech 42 11 1726 1731 19467661 10.1016/j.jbiomech.2009.04.017 1:STN:280:DC%2BD1Mris1aksg%3D%3D
47. Varga P, Pahr D, Dall'Ara E, Baumbach S, Pretterklieber M, Zysset P (2010) Calibrated HR-pQCT-based microFE models of ultra-distal radius sections provide outstanding prediction of experimental Colles' fracture load. 17th congress of the European society of biomechanics, University of Edinburgh, UK, 4-8 July 2010.
48. JA Macneil SK Boyd 2008 Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method Bone 42 1203 1213 18358799 10.1016/j.bone.2008.01.017
49. TL Mueller M Stauber T Kohler F Eckstein R Muller GH van Lenthe 2009 Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius Bone 44 364 371 19027092 10.1016/j.bone.2008.10.045
50. DH Pahr PK Zysset 2009 From high-resolution CT data to finite element models: development of an integrated modular framework Comput Meth Biomech Biomed Engin 12 45 57 10.1080/10255840802144105
51. AJ Burghardt GJ Kazakia TM Link S Majumdar 2009 Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography Osteoporos Int 20 2017 2024 19330422 10.1007/s00198-009-0907-0 1:STN:280:DC%2BC3c7mslOgtg%3D%3D
52. Y Chevalier M Charlebois D Pahra P Varga P Heini E Schneider P Zysset 2008 A patient-specific finite element methodology to predict damage accumulation in vertebral bodies under axial compression, sagittal flexion and combined loads Comput Meth Biomech Biomed Engin 11 477 487 10.1080/ 10255840802078022
53. Y Chevalier D Pahr PK Zysset 2009 The role of cortical shell and trabecular fabric in finite element analysis of the human vertebral body J. Biomech. Eng. 131 11 111003 20353254 10.1115/1.3212097
54. Dall'Ara E, Varga P, Pahr D, Zysset P (2010) Local BMD calibration of human vertebrae QCT using registered micro-CT images. European Symposium on Calcified Tissues 2010, Glasgow, UK, 26-30 June 2010.
55. PK Zysset A Curnier 1996 A 3D damage model for trabecular bone based on fabric tensors J Biomech 29 1549 1558 8945653 1:STN:280:DyaK2s7gtFWhtA%3D%3D
56. A Laib HJ Hauselmann P Ruegsegger 1998 In vivo high resolution 3D-QCT of the human forearm Technol Health Care 6 329 337 10100936 1:STN:280: DyaK1M7pvFSgtw%3D%3D
57. P Arbenz GH van Lenthe U Mennel R Mueller M Sala 2008 A scalable multi-level preconditioner for matrix-free-finite element analysis of human bone structures Int J Numer Methods Eng 73 927 947 10.1002/nme.2101
58. JH Steiger 1980 Tests for comparing elements of a correlation matrix Psychol bullettin 87 245 251 10.1037/0033-2909.87.2.245
59. RP Crawford CE Cann TM Keaveny 2003 Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography Bone 33 744 750 14555280 10.1016/S8756-3282(03)00210-2