Liver-induced inflammation hurts the brain

Journal of Hepatology

Volumn 56, Issue 3, 2012, Pages 515-517

  Garcia Martinez, Rita ^a   Cordoba, Juan ^b,c,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; BRAIN INFECTION; DISEASE ASSOCIATION; HEPATIC ENCEPHALOPATHY; HEPATITIS; IMMUNE RESPONSE; PARKINSON DISEASE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS;

EID: 84857371364     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.11.003     Document Type: Editorial

References (23)

1. J.P. Konsman, P. Parnet, and R. Dantzer Cytokine-induced sickness behaviour: mechanisms and implications Trends Neurosci 25 2002 154 159
2. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: when the immune system subjugates the brain Nat Rev Neurosci 9 2008 46 56
3. R.F. Butterworth Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 53 2011 1372 1376
4. M.D. Burton, N.L. Sparkman, and R.W. Johnson Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide- induced sickness behavior J Neuroinflammation 8 2011 54
5. M.M. Kaplan, R.A. DeLellis, and H.J. Wolfe Sustained biochemical and histologic remission of primary biliary cirrhosis in response to medical treatment Ann Intern Med 126 1997 682 688
6. I.M. Di, F. Falzetti, A. Carotti, A. Terenzi, F. Castellino, and E. Bonifacio Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation Blood 117 2011 3921 3928
7. S. Ahboucha, R.F. Butterworth, G. Pomier-Layrargues, C. Vincent, Z. Hassoun, and G.B. Baker Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C Neurogastroenterol Motil 20 2008 671 679
8. C. McDonald, J. Newton, H.M. Lai, S.N. Baker, and D.E. Jones Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms J Hepatol 53 2010 1095 1100
9. F. Wong, M. Bernardi, R. Balk, B. Christman, R. Moreau, and G. Garcia-Tsao Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club Gut 54 2005 718 725
10. V. Arvaniti, G. D'Amico, G. Fede, P. Manousou, E. Tsochatzis, and M. Pleguezuelo Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis Gastroenterology 139 2010 1246 1256
11. P. Gines, and R.W. Schrier Renal failure in cirrhosis N Engl J Med 361 2009 1279 1290
12. W.A. van Gool, D. van de Beek, and P. Eikelenboom Systemic infection and delirium: when cytokines and acetylcholine collide Lancet 375 2010 773 775
13. A. Rovira, B. Minguez, F.X. Aymerich, C. Jacas, E. Huerga, and J. Córdoba Decreased white matter lesion volume and improved cognitive function after liver transplantation Hepatology 46 2007 1485 1490
14. A. Cagnin, S.D. Taylor-Robinson, D.M. Forton, and R.B. Banati In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy Gut 55 2006 547 553
15. M.R. Garcia, A. Rovira, J. Alonso, F.X. Aymerich, E. Huerga, and C. Jacas A long-term study of changes in the volume of brain ventricles and white matter lesions after successful liver transplantation Transplantation 89 2010 589 594
16. M. Bokemeyer, X.Q. Ding, A. Goldbecker, P. Raab, M. Heeren, and D. Arvanitis Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy Gut 60 2011 370 377
17. C. Holmes, C. Cunningham, E. Zotova, D. Culliford, and V.H. Perry Proinflammatory cytokines, sickness behavior, and Alzheimer disease Neurology 77 2011 212 218
18. P.S. Aisen The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease Lancet Neurol 1 2002 279 284
19. O. Cauli, R. Rodrigo, B. Piedrafita, J. Boix, and V. Felipo Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts Hepatology 46 2007 514 519
20. D. Haussinger, and F. Schliess Pathogenetic mechanisms of hepatic encephalopathy Gut 57 2008 1156 1165
21. J.S. Bajaj, C.M. Schubert, D.M. Heuman, J.B. Wade, D.P. Gibson, and A. Topaz Persistence of cognitive impairment after resolution of overt hepatic encephalopathy Gastroenterology 138 2010 2332 2340
22. E.U. Sotil, J. Gottstein, E. Ayala, C. Randolph, and A.T. Blei Impact of preoperative overt hepatic encephalopathy on neurocognitive function after liver transplantation Liver Transpl 15 2009 184 192
23. R. Garcia-Martinez, A. Rovira, J. Alonso, C. Jacas, M. Simón-Talero, and L. Chavarria Hepatic encephalopathy is associated with posttransplant cognitive function and brain volume Liver Transpl 17 2011 38 46