c-KIT messenger RNA and protein expression and mutations in canine cutaneous mast cell tumors: Correlations with post-surgical prognosis

Journal of Veterinary Diagnostic Investigation

Volumn 24, Issue 1, 2012, Pages 116-126

  Giantin, Mery ^a   Vascellari, Marta ^b   Morello, Emanuela Maria ^c   Capello, Katia ^b   Vercelli, Antonella ^d   Granato, Anna ^b   Lopparelli, Rosa Maria ^a   Nassuato, Chiara ^b   Carminato, Antonio ^b   Martano, Marina ^c   Mutinelli, Franco ^b   Dacasto, Mauro ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Zooprofilattico Sperimentale delle Venezie   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d Ambulatorio Veterinario Associato   (Italy)

Author keywords

c KIT; dogs; mast cell tumor; messenger RNA expression; quantitative real time polymerase chain reaction

Indexed keywords

MESSENGER RNA; STEM CELL FACTOR RECEPTOR;

ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DOG DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; MUTATION; NUCLEIC ACID AMPLIFICATION; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SKIN; URTICARIA PIGMENTOSA;

ANIMALS; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MALE; MASTOCYTOSIS, CUTANEOUS; MUTATION; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-KIT; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN;

EID: 84857340185     PISSN: 10406387     EISSN: 19434936     Source Type: Journal    
DOI: 10.1177/1040638711425945     Document Type: Article

References (43)

1. Boissan M,Feger F,Guillosson JJ,Arock M.c-kit and c-kit mutations in mastocytosis and other hematological diseases.J Leukoc Biol. 2000;67:135-148.
2. Downing S,Chien MB,Kass PH, et al.Prevalence and importance of internal tandem duplications in exons 11 and 12 of c-kit in mast cell tumors of dogs.Am J Vet Res. 2002;63:1718-1723.
3. Fulcher RP,Ludwig LL,Bergman PJ, et al.Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs.J Am Vet Med Assoc. 2006;228:210-215.
4. Gil da Costa RM,Matos E,Rema A, et al.CD117 immunoexpression in canine mast cell tumours: correlations with pathological variables and proliferation markers.BMC Vet Res. 2007;3:19.
5. Goldschmidt MH,Hendrick MJTumors in domestic animals. 2002, Tumours of the skin and soft tissues. In: Tumors in domestic animals, ed. MeutenDJ, 4th ed., pp. 105-107. Iowa State University, Ames, IA.Meuten DJ, ed. Ames, IA: Iowa State University; 2002:105-107.
6. Hendrick MJ,Mahaffey EA,Moore FM, et alWHO classification of tumours of domestic animals. Washington, DC: Armed Forces Institute of Pathology; 1998:28-29.
7. Horny HP,Sotlar K,Valent P.Mastocytosis: state of the art.Pathobiology. 2007;74:121-132.
8. Jones CL,Grahn RA,Chien MB, et al.Detection of c-kit mutations in canine mast cell tumors using fluorescent polyacrylamide gel electrophoresis.J Vet Diagn Invest. 2004;16:95-100.
9. Kiupel M,Webster JD,Bailey KL, et al.Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior.Vet Pathol. 2011;48:147-155.
10. Kiupel M,Webster JD,Kaneene JB, et al.The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors.Vet Pathol. 2004;41:371-377.
11. Kiupel M,Webster JD,Miller RA,Kaneene JB.Impact of tumour depth, tumour location and multiple synchronous masses on the prognosis of canine cutaneous mast cell tumours.J Vet Med A Physiol Pathol Clin Med. 2005;52:280-286.
12. Krick EL,Billings AP,Shofer FS, et al.Cytological lymph node evaluation in dogs with mast cell tumours: association with grade and survival.Vet Comp Oncol. 2009;7:130-138.
13. Kubo K,Matsuyama S,Katayama K, et al.Frequent expression of the c-kit proto-oncogene in canine malignant mammary tumor.J Vet Med Sci. 1998;60:1335-1340.
14. Lee S,Jo M,Lee J, et al.Identification of novel universal housekeeping genes by statistical analysis of microarray data.J Biochem Mol Biol. 2007;40:226-231.
15. Letard S,Yang Y,Hanssens K, et al.Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors.Mol Cancer Res. 2008;6:1137-1145.
16. Linnekin D.Early signaling pathways activated by c-Kit in hematopoietic cells.Int J Biochem Cell Biol. 1999;31:1053-1074.
17. Livak KJ,Schimittgen TD.Methods. 2001;25:402-408.
18. London CA.Tyrosine kinase inhibitors in veterinary medicine.Top Companion Anim Med. 2009;24:106-112.
19. London CA,Galli SJ,Yuuki T, et al.Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit.Exp Hematol. 1999;27:689-697.
20. London CA,Kisseberth WC,Galli SJ, et al.Expression of stem cell factor receptor (c-kit) by the malignant mast cells from spontaneous canine mast cell tumours.J Comp Pathol. 1996;115:399-414.
21. London CA,Seguin B.Mast cell tumors in the dog.Vet Clin North Am Small Anim Pract. 2003;33:473-489.
22. Morini M,Bettini G,Preziosi R,Mandrioli L.C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections.J Histochem Cytochem. 2004;52:705-708.
23. Ohmori K,Kawarai S,Yasuda N, et al.Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells.Vet Immunol Immunopathol. 2008;126:43-53.
24. Ozaki K,Yamagami T,Nomura K,Narama I.Prognostic significance of surgical margins, Ki-67 and ciclin D1 protein expression in grade II canine cutaneous mast cell tumor.J Vet Med Sci. 2007;69:1117-1121.
25. Passantino L,Passantino G,Cianciotta A, et al.Expression of proto-oncogene C-kit and correlation with morphological evaluations in canine cutaneous mast cell tumors.Immunopharmacol Immunotoxicol. 2008;30:609-621.
26. Patnaik AK,Ehler WJ,MacEwen EG.Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs.Vet Pathol. 1984;21:469-474.
27. Preziosi R,Sarli G,Paltrinieri M.Prognostic value of intratumoral vessel density in cutaneous mast cell tumors of the dog.J Comp Pathol. 2004;130:143-151.
28. Rasmussen RRapid cycle real-time Quantification on the LightCycler PCR: methods and applications. Meuer SCWittwer CNakagawara K, ed. Heidelberg, Germany: Springer; 2001:21-34.
29. Riva F,Brizzola S,Stefanello D, et al.A study of mutations in the c-kit gene of 32 dogs with mastocytoma.J Vet Diagn Invest. 2005;17:385-388.
30. Romansik EM,Reilly CM,Kass PH, et al.Mitotic index is predictive for survival for canine cutaneous mast cell tumors.Vet Pathol. 2007;44:335-341.
31. J Vet Intern Med. Scase TJEdwards DMiller J, ed. 2006:151-158.
32. Simoes JP,Schoning P,Butine M.Prognosis of canine mast cell tumors: a comparison of three methods.Vet Pathol. 1994;31:637-647.
33. Simpson AM,Ludwig LL,Newman SJ, et al.Evaluation of surgical margins required for complete excision of cutaneous mast cell tumors in dogs.J Am Vet Med Assoc. 2004;224:236-240.
34. Thamm DH,Vail DMWithrow and MacEwen's small animal clinical oncology. 2007, Mast cell tumors. In: Withrow and MacEwen's small animal clinical oncology, 4th ed., pp. 402-424. WB Saunders, Philadelphia, PA.Philadelphia, PA: WB Saunders; 2007:402-424.
35. Thompson JJ,Pearl DL,Yager JA, et al.Canine subcutaneous mast cell tumor: characterization and prognostic indices.Vet Pathol. 2011;48:156-168.
36. Turin L,Acocella F,Stefanello D, et al.Expression of c-kit proto-oncogene in canine mastocytoma: a kinetic study using real-time polymerase chain reaction.J Vet Diagn Invest. 2006;18:343-349.
37. Webster JD,Kiupel M,Yuzbasiyan-Gurkan V.Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors.BMC Cancer. 2006;6:85.
38. Webster JD,Yuzbasiyan-Gurkan V,Kaneene JB, et al.The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumors.Neoplasia. 2006;8:104-111.
39. Webster JD,Yuzbasiyan-Gurkan V,Miller RA, et al.Cellular proliferation in canine cutaneous mast cell tumors: associations with c-KIT and its role in prognostication.Vet Pathol. 2007;44:298-308.
40. Webster JD,Yuzbasiyan-Gurkan V,Thamm DH, et al.Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone.BMC Vet Res. 2008;4:32.
41. Welle MM,Bley CR,Howard J,Rüfenacht S.Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment.Vet Dermatol. 2008;19:321-339.
42. Zemke D,Yamini B,Yuzbasiyan-Gurkan V.Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs.Vet Pathol. 2002;39:529-535.
43. Zwick E,Bange J,Ullrich A.Receptor tyrosine kinases as targets for anticancer drugs.Trends Mol Med. 2002;8:17-23.