Oral contraception enhances growth hormone responsiveness to hyper- and hypoglycaemia

Diabetic Medicine

Volumn 29, Issue 3, 2012, Pages 345-350

  Friedrich, A ^a   Ludwig, A K ^a   Jauch Chara, K ^a   Loebig, M ^a   Rudolf, S ^a   Tauchert, S ^a   Diedrich, K ^a   Schweiger, U ^a   Oltmanns, K M ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Diabetes mellitus; Glucose metabolism; Growth hormone; Hypoglycaemia counterregulation; Oral contraception

Indexed keywords

CHLORMADINONE ACETATE PLUS ETHINYLESTRADIOL; DESOGESTREL PLUS ETHINYLESTRADIOL; DIENOGEST PLUS ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS LEVONORGESTREL; ETHINYLESTRADIOL PLUS NORGESTIMATE; FEMIGOA; GLUCOSE; GROWTH HORMONE; LEIOS; ORAL CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GROWTH HORMONE BLOOD LEVEL; HORMONE SENSITIVITY; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; HYPOGLYCEMIA; NORMAL HUMAN; ORAL CONTRACEPTION;

ADULT; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; CONTRACEPTIVES, ORAL, COMBINED; ETHINYL ESTRADIOL; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN GROWTH HORMONE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN RESISTANCE; PROSPECTIVE STUDIES;

EID: 84857325368     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2011.03430.x     Document Type: Article

References (26)

1. Bramnert M, Segerlantz M, Laurila E, Daugaard JR, Manhem P, Groop L. Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle. J Clin Endocrinol Metab 2003; 88: 1455-1463.
2. Giavoli C, Porretti S, Ronchi CL, Cappiello V, Ferrante E, Orsi E et al. Long-term monitoring of insulin sensitivity in growth hormone-deficient adults on substitutive recombinant human growth hormone therapy. Metabolism 2004; 53: 740-743.
3. Holt RI, Simpson HL, Sonksen PH. The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis. Diabet Med 2003; 20: 3-15.
4. Moller N, Jorgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev 2009; 30: 152-177.
5. Moller N, Jorgensen JO, Alberti KG, Flyvbjerg A, Schmitz O. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 1990; 70: 1179-1186.
6. Moller N, Jorgensen JO, Schmitz O, Moller J, Christiansen J, Alberti KG et al. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol 1990; 258: E86-E91.
7. Djurhuus CB, Gravholt CH, Nielsen S, Pedersen SB, Moller N, Schmitz O. Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans. Am J Physiol Endocrinol Metab 2004; 286: E488-E494.
8. de Galan BE, Schouwenberg BJ, Tack CJ, Smits P. Pathophysiology and management of recurrent hypoglycaemia and hypoglycaemia unawareness in diabetes. Neth J Med 2006; 64: 269-279.
9. Rickenlund A, Thoren M, Nybacka A, Frystyk J, Hirschberg AL. Effects of oral contraceptives on diurnal profiles of insulin, insulin-like growth factor binding protein-1, growth hormone and cortisol in endurance athletes with menstrual disturbance. Hum Reprod 2010; 25: 85-93.
10. Engstrom BE, Karlsson FA, Wide L. Gender differences in diurnal growth hormone and epinephrine values in young adults during ambulation. Clin Chem 1999; 45: 1235-1239.
11. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd edn. Hillsdale, NJ: Lawrence Erlbaum Associates Inc., 1988.
12. Erdfelder E, Faul F, Buchner A. G*Power: A general power analysis program. Behav Res Methods Instrum Comput 1996; 28: 1-11.
13. Mishell DR Jr, Kletzky OA, Brenner PF, Roy S, Nicoloff J. The effect of contraceptive steroids on hypothalamic-pituitary function. Am J Obstet Gynecol 1977; 128: 60-74.
14. Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998; 19: 717-797.
15. Wideman L, Weltman JY, Shah N, Story S, Veldhuis JD, Weltman A. Effects of gender on exercise-induced growth hormone release. J Appl Physiol 1999; 87: 1154-1162.
16. Pritzlaff-Roy CJ, Widemen L, Weltman JY, Abbott R, Gutgesell M, Hartman ML et al. Gender governs the relationship between exercise intensity and growth hormone release in young adults. J Appl Physiol 2002; 92: 2053-2060.
17. Faria AC, Bekenstein LW, Booth RA Jr, Vaccaro VA, Asplin CM, Veldhuis JD et al. Pulsatile growth hormone release in normal women during the menstrual cycle. Clin Endocrinol (Oxf) 1992; 36: 591-596.
18. Ovesen P, Vahl N, Fisker S, Veldhuis JD, Christiansen JS, Jorgensen JO et al. Increased pulsatile, but not basal, growth hormone secretion rates and plasma insulin-like growth factorI levels during the periovulatory interval in normal women. J Clin Endocrinol Metab 1998; 83: 1662-1667.
19. Micic D, Kendereski A, Sumarac-Dumanovic M, Cvijovic G, Popovic V, Dieguez C et al. Growth hormone response to GHRH+GHRP-6 in type2 diabetes during euglycemic and hyperglycemic clamp. Diabetes Res Clin Pract 2004; 63: 37-45.
20. Bonora E, Moghetti P, Zenere M, Querena M, Tosi F, Corgnati A et al. Plasma concentrations of growth hormone during hyperglycemic clamp with or without somatostatin infusion in obese subjects. J Clin Endocrinol Metab 1990; 70: 1732-1734.
21. Cryer PE. Hypoglycaemia: the limiting factor in the glycaemic management of TypeI and TypeII diabetes. Diabetologia 2002; 45: 937-948.
22. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J. Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 1993; 42: 1233-1237.
23. Fanelli CG, Paramore DS, Hershey T, Terkamp C, Ovalle F, Craft S et al. Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type1 diabetes. Diabetes 1998; 47: 1920-1927.
24. Davis MR, Shamoon H. Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J Clin Endocrinol Metab 1991; 73: 995-1001.
25. Fruehwald-Schultes B, Kern W, Oltmanns KM, Sopke S, Toschek B, Born J et al. Metformin does not adversely affect hormonal and symptomatic responses to recurrent hypoglycemia. J Clin Endocrinol Metab 2001; 86: 4187-4192.
26. Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A. Hypoglycemia unawareness. Endocr Rev 1991; 12: 356-371.