Clozapine administration ameliorates disrupted long-range synchrony in a neurodevelopmental animal model of schizophrenia

Schizophrenia Research

Volumn 135, Issue 1-3, 2012, Pages 112-115

  Dickerson, Desiree D ^a   Restieaux, Aleisha M ^a   Bilkey, David K ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Animal model; Clozapine; Hippocampus; PolyI:C; Prefrontal; Schizophrenia; Synchrony

Indexed keywords

CLOZAPINE;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROENCEPHALOGRAM; FEMALE; HIPPOCAMPUS; IMMUNOSTIMULATION; MALE; MATERNAL IMMUNE ACTIVATION; NERVE CELL NETWORK; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY PHASE SYNCHRONIZATION; EXPLORATORY BEHAVIOR; FEMALE; HIPPOCAMPUS; MALE; POLY I-C; PREFRONTAL CORTEX; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; REST; SCHIZOPHRENIA;

EID: 84857237367     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2011.12.016     Document Type: Article

References (29)

1. Abi-Dargham A., Moore H. Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia. Neuroscientist 2003, 9(5):404-416.
2. Brown A.S., Begg M.D., Gravenstein S., Schaefer C.A., Wyatt R.J., Bresnahan M., et al. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch. Gen. Psychiatry 2004, 61(8):774-780.
3. Dickerson D.D., Wolff A.R., Bilkey D.K. Abnormal long-range neural synchrony in a maternal immune activation animal model of schizophrenia. J. Neurosci. 2010, 30(37):12424-12431.
4. Harrison P.J. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl) 2004, 174(1):151-162.
5. Homayoun H., Moghaddam B. Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine. Biol. Psychiatry 2007, 61(5):679-687.
6. Hong L.E., Summerfelt A., McMahon R., Adami H., Francis G., Elliott A., et al. Evoked gamma band synchronization and the liability for schizophrenia. Schizophr. Res. 2004, 70(2-3):293-302.
7. Joutsiniemi S.L., Gross A., Appelberg B. Marked clozapine-induced slowing of EEG background over frontal, central, and parietal scalp areas in schizophrenic patients. J. Clin. Neurophysiol. 2001, 18(1):9-13.
8. Kargieman L., Santana N., Mengod G., Celada P., Artigas F. Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(37):14843-14848.
9. Keefe R.S., Silva S.G., Perkins D.O., Lieberman J.A. The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophr. Bull. 1999, 25(2):201-222.
10. Knott V.J., LaBelle A., Jones B., Mahoney C. EEG coherence following acute and chronic clozapine in treatment-resistant schizophrenics. Exp. Clin. Psychopharmacol. 2002, 10(4):435-444.
11. Koenig T., Lehmann D., Saito N., Kuginuki T., Kinoshita T., Koukkou M. Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results. Schizophr. Res. 2001, 50(1-2):55-60.
12. Lacroix D., Chaput Y., Rodriguez J.P., Filion M., Morrison D., St-Denis P., et al. Quantified EEG changes associated with a positive clinical response to clozapine in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 1995, 19(5):861-876.
13. Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 2005, 6(4):312-324.
14. Manschreck T.C., Redmond D.A., Candela S.F., Maher B.A. Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 1999, 11(4):481-489.
15. Meyer U., Feldon J., Schedlowski M., Yee B.K. Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia. Neurosci. Biobehav. Rev. 2005, 29(6):913-947.
16. Meyer U., Knuesel I., Nyffeler M., Feldon J. Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis. Psychopharmacology (Berl) 2010, 208(4):531-543.
17. O'Donnell P. Dopamine gating of forebrain neural ensembles. Eur. J. Neurosci. 2003, 17(3):429-435.
18. Patterson P.H. Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr. Opin. Neurobiol. 2002, 12(1):115-118.
19. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, San Diego, CA. 4th Edition.
20. Puig M.V., Watakabe A., Ushimaru M., Yamamori T., Kawaguchi Y. Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors. J. Neurosci. 2010, 30(6):2211-2222.
21. Saito N., Kuginuki T., Yagyu T., Kinoshita T., Koenig T., Pascual-Marqui R.D., et al. Global, regional, and local measures of complexity of multichannel electroencephalography in acute, neuroleptic-naive, first-break schizophrenics. Biol. Psychiatry 1998, 43(11):794-802.
22. Saletu B., Grunberger J., Linzmayer L., Anderer P. Comparative placebo-controlled pharmacodynamic studies with zotepine and clozapine utilizing pharmaco-EEG and psychometry. Pharmacopsychiatry 1987, 20(1 Spec No):12-27.
23. Sebban C., Tesolin-Decros B., Ciprian-Ollivier J., Perret L., Spedding M. Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA-, alpha(1)- and 5-HT(2A)-receptors. Br. J. Pharmacol. 2002, 135(1):65-78.
24. Sebban C., Tesolin-Decros B., Millan M.J., Spedding M. Contrasting EEG profiles elicited by antipsychotic agents in the prefrontal cortex of the conscious rat: antagonism of the effects of clozapine by modafinil. Br. J. Pharmacol. 1999, 128(5):1055-1063.
25. Singer W. Neuronal synchrony: a versatile code for the definition of relations?. Neuron 1999, 24(1):49-65. 111-125.
26. Tan H.Y., Callicott J.H., Weinberger D.R. Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia. Cereb. Cortex 2007, 17(Suppl 1):i171-i181.
27. Uhlhaas P.J., Singer W. Abnormal neural oscillations and synchrony in schizophrenia. Nat. Rev. Neurosci. 2010, 11(2):100-113.
28. Wolff A.R., Bilkey D.K. The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss. Behav. Brain Res. 2010, 213(2):323-327.
29. Zuckerman L., Weiner I. Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J. Psychiatr. Res. 2005, 39(3):311-323.