Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Leukemia Research

Volumn 36, Issue 4, 2012, Pages 474-478

  Ottone, T ^a,b   Cicconi, L ^a,b   Hasan, S K ^a,b   Lavorgna, S ^a,b   Divona, M ^a,b   Voso, M T ^c   Montefusco, E ^d   Melillo, L ^e   Barragan E ^f   Platzbecker, U ^g   Gianni L ^a   Hubmann, M ^h   Pagoni, M ⁱ   Amadori, S ^a   Lo Coco, F ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^f HOSPITAL UNIVERSITARIO LA FE   (Spain)

^g UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^h UNIVERSITY OF MUNICH   (Germany)

ⁱ EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Acute Promyelocytic Leukemia; DNMT3A mutation; IDHs mutation; TET2 mutation; Therapy related leukemia

Indexed keywords

GENOMIC DNA; RNA;

ARTICLE; BONE MARROW; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; DNM3TA GENE; FEMALE; FLT3 GENE; GENE; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IDH1 GENE; IDH2 GENE; LEUKEMOGENESIS; MALE; MOLECULAR GENETICS; MOLECULAR PATHOLOGY; MUTATION RATE; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; TET ONCOGENE FAMILY MEMBER 2 GENE;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CHILD; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; FMS-LIKE TYROSINE KINASE 3; HUMANS; ISOCITRATE DEHYDROGENASE; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; RADIOTHERAPY; YOUNG ADULT;

EID: 84857232561     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.10.015     Document Type: Article

References (6)

1. Mistry A.R., Felix C.A., Whitmarsh R.J., Mason A., Reiter A., Cassinat B., et al. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med 2005, 352:1529-1538.
2. Hasan S.K., Ottone T., Schlenk R.F., Xiao Y., Wiemels J.L., Mitra M.E., et al. Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci. Genes Chromosomes Cancer 2010, 49:726-732.
3. Marcucci G., Haferlach T., Döhner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011, 29:475-486.
4. Ley T.J., Ding L., Walter M.J., McLellan M.D., Lamprecht T., Larson D.E., et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010, 363:2424-2433.
5. Noguera N.I., Breccia M., Divona M., Diverio D., Costa V., De Santis S., et al. Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol. Leukemia 2002, 16:2185-2189.
6. Yin C.C., Glassman A.B., Lin P., Valbuena J.R., Jones D., Luthra R., et al. Morphologic, cytogenetic, and molecular abnormalities in therapy-related acute promyelocytic leukemia. Am J Clin Pathol 2005, 123:840-848.