Creatine ethyl ester: A new substrate for creatine kinase

Molecular Biology

Volumn 46, Issue 1, 2012, Pages 149-152

  Ravera, S ^a   Adriano, E ^a   Balestrino, M ^a   Panfoli, I ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

creatine, creatine ethyl ester, creatine phosphokinase, phosphocreatine, phosphagene

Indexed keywords

EID: 84857220158     PISSN: 00268933     EISSN: 16083245     Source Type: Journal    
DOI: 10.1134/S0026893312010190     Document Type: Article

References (31)

1. Andres R. H., Ducray A. D., Schlattner U., Wallimann T., Widmer H. R. 2008. Functions and effects of creatine in the central nervous system. Brain Res. Bull. 76, 329-343.
2. Brosnan M. E., Edison E. E., da Silva R., Brosnan J. T. 2007. New insights into creatine function and synthesis. Adv. Enzyme Regul. 47, 252-260.
3. Braissant O., Henry H., Loup M., Eilers B., Bachmann C. 2001. Endogenous synthesis and transport of creatine in the rat brain: An in situ hybridization study. Mol. Brain Res. 86, 193-201.
4. Braissant O., Henry H., Villard A. M., Speer O., Wallimann T., Bachmann C. 2005. Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT, GAMT, and CT1. BMC Dev. Biol. 5, 9.
5. - creatine transporter: Functional, molecular characterization and localization. J. Physiol. 545, 133-144.
6. cLeish M. J., Kenyon G. L. 2005. Relating structure to mechanism in creatine kinase. Crit. Rev. Biochem. Mol. Biol. 40, 1-20.
7. Saks V. A., Ventura-Clapier R., Aliev M. K. 1996. Metabolic control and metabolic capacity: Two aspects of creatine kinase functioning in the cells. Biochim. Biophys. Acta. 1274, 81-88.
8. Wallimann T., Dolder M., Schlattner U., Eder M., Hornemann T., O'Gorman E., Ruck A., Brdiczka D. 1998. Some new aspects of creatine kinase (CK): Compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology. Biofactors. 8, 229-234.
9. Wyss M., Smeitink J., Wevers R. A., Wallimann T. 1992. Mitochondrial creatine kinase: A key enzyme of aerobic energy metabolism. Biochim. Biophys. Acta. 1102, 119-166.
10. Wallimann T., Schnyder T., Schlegel J., Wyss M., Wegmann G., Rossi A. M., Hemmer W., Eppenberger H. M., Quest A. F. 1989. Subcellular compartmentation of creatine kinase isoenzymes, regulation of CK and octameric structure ofmitochondrial CK: Important aspects of the phosphoryl-creatine circuit. Prog. Clin. Biol. Res. 315, 159-176.
11. Ventura-Clapier R., Kuznetsov A., Veksler V., Boehm E., Anflous K. 1998. Functional coupling of creatine kinases in muscles: Species and tissue specificity. Mol. Cell. Biochem. 184, 231-247.
12. Wallimann T., Hemmer W. 1994. Creatine kinase in non-muscle tissues and cells. Mol. Cell. Biochem. 133-134, 193-220.
13. Chen L., Roberts R., Friedman D. L. 1995. Expression of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in the fetal rat brain: Evidence for a nuclear energy shuttle. J. Comp. Neurol. 363, 389-401.
14. Meyer R. A., Sweeney H. L., Kushmerick M. J. 1984. A simple analysis of the "phosphocreatine shuttle." Am. J. Physiol. 246, C365-C377.
15. Bessman S. P., Carpenter C. L. 1985. The creatine-creatine phosphate energy shuttle. Annu. Rev. Biochem. 54, 831-862.
16. Wallimann T., Wyss M., Brdiczka D., Nicolay K., Eppenberger H. M. 1992. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasis. Biochem. J. 281, 21-40.
17. Schlattner U., Wallimann T. 2004. Metabolite channeling: Creatine kinase icrocompartments. In: Encyclopedia of Biological Chemistry. Eds. Lennarz W. J., Lane M. D. NY: Academic Press, pp. 646-651.
18. Hespel P., Maughan R. J., Greenhaff P. L. 2006. Dietary supplements for football. J. Sports Sci. 24, 749-761.
19. Tipton K. D., Ferrando A. A. 2008. Improving muscle mass: Response of muscle metabolism to exercise, nutrition and anabolic agents. Essays in Biochemistry. 44, 85-98.
20. Ferguson C., Shengli J. 2008. US Patent Appl. Publ. 103202, 5.
21. Bergmeyer H. V. (Ed.). 1974. Methods of Enzymatic Analysis. Verlag Chemie-Academic Press.
22. Ravera S., Panfoli I., Calzia D., Aluigi M. G., Bianchini P., Diaspro A., Mancardi G., Morelli A. 2009. Evidence for aerobic ATP synthesis in isolated myelin vesicles. Int. J. Biochem. Cell. Biol. 41, 1581-1591.
23. Ames III A. 2000. CNS energy metabolism as related to function. Brain Res. Rev. 34, 42-68.
24. Erecinska M., Silver I. A. 1989. ATP and brain function. J. Cereb. Blood Flow Metab. 9, 2-19.
25. Watanabe A., Kato N., Kato T. 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci. Res. 42, 279-285.
26. In 't Zandt H. J., Renema W. K., Streijger F., Jost C., Klomp D. W., Oerlemans F., van der Zee C. E., Wieringa B., Heerschap A. 2004. Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: A quantitative in vivo 1H and 31P magnetic resonance study. J. Neurochem. 90, 1321-1330.
27. Wyss M., Wallimann T. 1994. Creatine metabolism and the consequences of creatine depletion in muscle. Mol. Cell. Biochem. 133-134, 51-66.
28. Stockler S., Schulz P. W., Salomons G. S. 2007. Cerebral creatine deficiency syndromes: clinical aspects treatment and pathophysiology. In: Creatine and Creatine Kinase in Health and Disease. Subcellular Biochemistry. Eds. Salomons G. S., Wyss M. Dordrecht: Springer, vol. 46, pp. 149-166.
29. Ling J., Kritikos M., Tiplady B. 2009. Cognitive effects of creatine ethyl ester supplementation. Behav. Pharmacol. 20, 673-679.
30. Velema M. S., de Ronde W. 2011. Elevated plasma creatinine due to creatine ethyl ester use. Netherl. J. Med. 69, 79-81.
31. Giese M. W., Lecher C. S. 2009. Non-enzymatic cyclization of creatine ethyl ester to creatinine. Biochem. Biophys. Res. Commun. 388, 252-255.