Antibacterial activity of sphingoid bases and fatty acids against gram-positive and gram-negative bacteria

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 3, 2012, Pages 1157-1161

  Fischer, Carol L ^a   Drake, David R ^a   Dawson, Deborah V ^a   Blanchette, Derek R ^a   Brogden, Kim A ^a   Wertz, Philip W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LAURIC ACID; LIPID; PHYTOSPHINGOSINE; SAPIENIC ACID; SPHINGANINE; SPHINGOID BASE; SPHINGOSINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CORYNEBACTERIUM; CORYNEBACTERIUM STRIATUM; ESCHERICHIA COLI; FUSOBACTERIUM NUCLEATUM; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; KRUSKAL WALLIS TEST; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS MITIS; STREPTOCOCCUS SANGUINIS;

ANTI-BACTERIAL AGENTS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; IMMUNITY, INNATE; LAURIC ACIDS; MICROBIAL SENSITIVITY TESTS; MOUTH; PALMITIC ACIDS; SKIN; SPECIES SPECIFICITY; SPHINGOSINE;

EID: 84857157129     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05151-11     Document Type: Article

References (27)

1. Arikawa J, et al. 2002. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus. J. Investig. Dermatol. 119:433-439.
2. Bergsson G, Arnfinnsson J, Steingrimsson O, Thormar H. 2001. In vitro killing of Candida albicans by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 45:3209-3212. (Pubitemid 32988853)
3. Bergsson G, Arnfinnsson J, Steingrimsson O, Thormar H. 2001. Killing of Gram-positive cocci by fatty acids and monoglycerides. APMIS 109: 670-678. (Pubitemid 33020633)
4. Bibel DJ, Aly R, Shah S, Shinefield HR. 1993. Sphingosines: antimicrobial barriers of the skin. Acta Derm. Venereol. 73:407-411. (Pubitemid 23351334)
5. Brasser A, et al. 2011. Free sphingosine in human saliva. J. Dent. Res. 90(Special issue A):3465. (Abstract.) http://www.dentalresearch.org.
6. Brasser AJ, et al. 2011. Presence of wax esters and squalene in human saliva. Arch. Oral Biol. 56:588-591.
7. Bratt CL, Dawson D, Drake D, Brogden KA, Wertz P. 2010. Oral mucosal lipids: antibacterial activity and induction of ultrastructural damage. J. Dent. Res. 89(Special issue A):679. (Abstract.) http://www. dentalresearch.org.
8. Cameron DJ, et al. 2007. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int. J. Biol. Sci. 3:111-119. (Pubitemid 46238637)
9. Dale BA. 2002. Periodontal epithelium: a newly recognized role in health and disease. Periodontol. 2000 30:70-78.
10. Drake DR, Brogden KA, Dawson DV, Wertz PW. 2008. Thematic review series: skin lipids. Antimicrobial lipids at the skin surface. J. Lipid Res. 49:4-11.
11. Drake DR, Wiemann AH, Rivera EM, Walton RE. 1994. Bacterial retention in canal walls in vitro: effect of smear layer. J. Endod. 20:78-82.
12. Gallo RL, Murakami M, Ohtake T, Zaiou M. 2002. Biology and clinical relevance of naturally occurring antimicrobial peptides. J. Allergy Clin. Immunol. 110:823-831.
13. Grice EA, Segre JA. 2011. The skin microbiome. Nat. Rev. Microbiol. 9:244-253.
14. Jungersted JM, Hellgren LI, Jemec GB, Agner T. 2008. Lipids and skin barrier function - a clinical perspective. Contact Dermatitis 58:255-262. (Pubitemid 351537624)
15. Kalfa VC, et al. 2001. Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells. Antimicrob. Agents Chemother. 45:3256-3261. (Pubitemid 32988867)
16. Klee SK, Farwick M, Lersch P. 2007. The effect of sphingolipids as a new therapeutic option for acne treatment. Basic Clin. Dermatol. 40:155-166.
17. Nakatsuji T, et al. 2009. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J. Investig. Dermatol. 129:2480-2488.
18. Pavicic T, Wollenweber U, Farwick M, Korting HC. 2007. Antimicrobial and-inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. Int. J. Cosmet. Sci. 29:181-190. (Pubitemid 47024255)
19. Proksch E, Brandner JM, Jensen JM. 2008. The skin: an indispensable barrier. Exp. Dermatol. 17:1063-1072.
20. Smith KR, Thiboutot DM. 2008. Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe? J. Lipid Res. 49:271-281. (Pubitemid 351213612)
21. Spiegel S, Milstien S. 2011. The outs and the ins of sphingosine-1- phosphate in immunity. Nat. Rev. Immunol. 11:403-415.
22. Takigawa H, Nakagawa H, Kuzukawa M, Mori H, Imokawa G. 2005. Deficient production of hexadecenoic acid in the skin is associated in part with the vulnerability of atopic dermatitis patients to colonization by Staphylococcus aureus. Dermatology 211:240-248. (Pubitemid 41415864)
23. Thormar H, Hilmarsson H. 2007. The role of microbicidal lipids in host defense against pathogens and their potential as therapeutic agents. Chem. Phys. Lipids 150:1-11. (Pubitemid 47538552)
24. Turner J, Cho Y, Dinh NN, Waring AJ, Lehrer RI. 1998. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother. 42:2206-2214. (Pubitemid 28420351)
25. Zarco MF, Vess TJ, Ginsburg GS. 11 August 2011. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis. [Epub ahead of print.] doi:10.1111/j.1601- 0825.2011.01851.x.
26. Zouboulis CC. 2004. Acne and sebaceous gland function. Clin. Dermatol. 22:360-366. (Pubitemid 39535276)
27. Zouboulis CC, et al. 2008. Frontiers in sebaceous gland biology and pathology. Exp. Dermatol. 17:542-551. (Pubitemid 351663284)