Oxymetazoline ototoxicity in a chinchilla animal model

Otolaryngology - Head and Neck Surgery

Volumn 146, Issue 1, 2012, Pages 114-118

  Daniel, Sam J ^a   Akinpelu, Olubunmi V ^a   Sahmkow, Sofia ^a   Funnell, W Robert J ^a   Akache, Fadi ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Ototoxicity; Oxymetazoline; Scanning electron microscopy; Tympanostomy tubes

Indexed keywords

GARASONE; GENTAMICIN; OXYMETAZOLINE; UNCLASSIFIED DRUG; DECONGESTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINCHILLA; COCHLEA; CONTROLLED STUDY; DISSECTION; DRUG SAFETY; ELECTRON MICROSCOPY; FEMALE; NONHUMAN; OTOACOUSTIC EMISSION; OTOTOXICITY; SCANNING ELECTRON MICROSCOPY; TYMPANOSTOMY TUBE; ANIMAL; CEREBROSPINAL FLUID OTORRHEA; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; FOLLOW UP; MIDDLE EAR VENTILATION; PATHOLOGY; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RABBIT; SCALA VESTIBULI; SPONTANEOUS OTOACOUSTIC EMISSION; TOPICAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADMINISTRATION, TOPICAL; ANIMALS; CEREBROSPINAL FLUID OTORRHEA; CHINCHILLA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; MICROSCOPY, ELECTRON, SCANNING; MIDDLE EAR VENTILATION; NASAL DECONGESTANTS; OTOACOUSTIC EMISSIONS, SPONTANEOUS; OXYMETAZOLINE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RABBITS; SCALA VESTIBULI;

EID: 84857154052     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599811419082     Document Type: Article

References (18)

1. Ah-Tye C, Paradise JL, Colborn DK. Otorrhea in young children after tympanostomy-tube placement for persistent middle-ear effusion: prevalence, incidence, and duration. Pediatrics. 2001;107:1251-1258. (Pubitemid 32525198)
2. Isaacson G, Rosenfeld RM. Care of the child with tympanostomy tubes. Pediatr Clin North Am. 1996;43:1183-1193. (Pubitemid 26427853)
3. Schraff SA. Contemporary indications for ventilation tube placement. Curr Opin Otolaryngol Head Neck Surg. 2008;16:406-411.
4. Friedman RA, Kesser BW. Surgery of ventilation and mucosal disease. In: Brackmann DE, Sleighton C, eds. Otologic Surgery. 2nd ed. Philadelphia, PA: W. B. Saunders; 2001.
5. Kumar VV, Gaughan J, Isaacson G, Szeremeta W. Oxymetazoline is equivalent to ciprofloxacin in preventing postoperative otorrhea or tympanostomy tube obstruction. Laryngoscope. 2005;115:363-365. (Pubitemid 40216720)
6. Isaacson G, Buttaro BA, Mazeffa V, et al. Oxymetazoline solutions inhibit middle ear pathogens and are not ototoxic. Ann Otol Rhinol Laryngol. 2005;114:645-651. (Pubitemid 41170057)
7. Korver KD, Rybak LP, Whitworth C, et al. Round window application of D-methionine provides complete cisplatin otoprotection. Otolaryngol Head Neck Surg. 2002;126:683-689. (Pubitemid 41115249)
8. Canada JR, ed. USP Dictionary of USAN and International Drug Names, 1998. Rockville, MD: The United States Pharmacopeial Convention Inc; 1997:542.
9. Kobinger W. Central a-adrenergic systems as targets for hypotensive drugs. Rev Physiol Biochem Pharmacol. 1978;81:39-100.
10. Jeon E, Park Y, Lee S, et al. Lee D, Factors of the blockage of ventilation tubes in the immediate postoperative period; Eur Arch Otorhinolaryngol. 2007;264:1393-1397. (Pubitemid 350112394)
11. Elden LM, Marsh RR. Survey of pediatric otolaryngologists: clinical practice trends used to prevent and treat blocked ventilation ear tubes in children. Int J Pediatr Otorhinolaryngol. 2006;70:1533-1538. (Pubitemid 44209190)
12. Seidman MD. Is oxymetazoline really safe for middle ear use? Laryngoscope. 2005;115:1321-1323. (Pubitemid 40962380)
13. Hamaguchi Y, Morizono T, Juhn SK. Round window membrane permeability to serum albumin in antigen-induced otitis media. Am J Otolaryngol. 1988;9:34-40.
14. Miller JM, Laurikainen EA, Grenman R, et al. Epinephrine induced changes in human cochlear blood flow. Am J Otol. 1994;15:299-306. (Pubitemid 24164935)
15. Ohlsén KA, Baldwin DL, Nuttall AL, et al. Influence of topically applied adrenergic agents on cochlear blood flow. Circ Res. 1991;69:509-518.
16. Altman JS, Haupert MS, Hamaker RA, et al. Phenylephrine and the prevention of post-operative tympanostomy tube obstruction. Arch Otolaryngol Head Neck Surg. 1998;124:1233-1236. (Pubitemid 28522961)
17. Daniel SJ, Duval M, Sahmkow S, et al. Ototoxicity of topical moxifloxacin in a chinchilla animal model. Laryngoscope. 2007;117:2201-2205. (Pubitemid 351339597)
18. Goycoolea MV, Lundman L. Round window membrane: structure function and permeability: a review. Microsc Res Tech. 1997;36:201-211. (Pubitemid 27120351)