Statin-associated myopathy

U.S. Pharmacist

Volumn 37, Issue 2, 2012, Pages 55-59

  Shannon, Jennifer ^b   John, Samuel ^b   Ferrara, Jenna ^b   Best, Sylvia ^b   Allen, Shari N ^a  

^a PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CHOLESTEROL; CREATINE KINASE; CYCLOSPORIN; CYTOCHROME P450 3A4; FLUCONAZOLE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVINOLIN; ROSUVASTATIN; UBIQUINOL CYTOCHROME C REDUCTASE; VITAMIN D;

AGE; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; DIABETES MELLITUS; DIET; DRUG EFFICACY; DRUG SAFETY; DRUG USE; DYSLIPIDEMIA; EXERCISE; GENDER; HUMAN; HYPERTENSION; HYPOTHYROIDISM; KIDNEY DISEASE; LIVER DISEASE; MUSCLE CRAMP; MYOPATHY; PATIENT COUNSELING; PATIENT EDUCATION; PATIENT MONITORING; RHABDOMYOLYSIS;

EID: 84857148365     PISSN: 01484818     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (34)

1. IMS Institute for Health Informatics. The Use of Medicines in the United States: Review of 2010. Updated April 2011. www.imshealth.com/deployedfiles/imshealth/Global/Content/IMS%20Institute/Static%20File/IHII_UseOfMed_report.pdf. Accessed September 21, 2011.
2. Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern Med. 2009;150:858-868.
3. Harper CR, Jacobson TA. Evidence-based management of statin myopathy. Curr Atheroscler Rep. 2010;12:322-330.
4. Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc Drugs Ther. 2005;19:403-414.
5. For consumers. FDA: Limit use of 80 mg simvastatin. Updated June 2011. www.fda.gov/ForConsumers/ConsumerUpdates/ucm257884.htm. Accessed January 10, 2012.
6. Harper CR, Jacobson TA. The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis. Curr Opin Lipidol. 2007;18:401-408.
7. Chatzizisis Y, Koskinas K, Misirli G, et al. Risk factors and drug interactions predisposing to statin-induced myopathy. Drug Saf. 2010;33:171-187.
8. Hodel C. Myopathy and rhabdomyolysis with lipid-lowering drugs. Toxicol Lett. 2002;128:159-168.
9. Abd TT, Jacobson TA. Statin-induced myopathy: a review and update. Expert Opin Drug Saf. 2011;10:373-385.
10. Guijarro C, Blanco-Colio L, Ortego M, et al. 3-hydroxy-3-methyglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res. 1998;83:490-500.
11. Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin Pharmacol Ther. 1995;57:62-66.
12. Marcoff L, Thompson PD. The role of CoQ10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol. 2007;49:2231-2237.
13. Young J, Florkowski C, Molyneux S, et al. Effect of coenzyme Q10 supplementation on simvastatin-induced myalgia. Am J Cardiol. 2007;100:1400-1403.
14. Sathasivam S, Lecky B. Statin-induced myopathy. BMJ. 2008;337:1159-1162.
15. Omar M, Wilson J, Cox T. Rhabdomyolysis and HMG-CoA reductase inhibitors. Ann Pharmacother. 2001;35:1096-1107.
16. Graham D, Staffa J, Shatin D, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA. 2004;292:2585-2590.
17. Rosenson R. Current overview of statin-induced myopathy. Am J Med. 2004;116:408-416.
18. Arora R, Liebo M, Maldonado F. Statin-induced myopathy: the two faces of Janus. J Cardiovasc Pharmacol Ther. 2006;11:105-112.
19. Antons K, Williams C, Baker S, et al. Clinical perspectives of statin-induced rhabdomyolysis. Am J Med. 2006;119:400-409.
20. Lipitor (atorvastatin) package insert. New York, NY: Pfizer, Inc; January 2012.
21. Lescol (fluvastatin) package insert. East Hanover, NJ: Novartis Pharmaceuticals Corporation; July 2011.
22. Mevacor (lovastatin) package insert. Whitehouse Station, NJ: Merck & Co., Inc; May 2010.
23. Livalo (pitavastatin) package insert. Montgomery, AL: Kowa Pharmaceuticals America, Inc; August 2011.
24. Pravachol (pravastatin) package insert. Princeton, NJ: Bristol-Meyers Squibb; May 2011.
25. Crestor (rosuvastatin) package insert. Wilmington, DE: AstraZeneca Pharmaceuticals; June 2011.
26. Zocor (simvastatin) package insert. Whitehouse Station, NJ: Merck & Co., Inc; October 2011.
27. Sewright K, Clarkson P, Thompson P. Statin myopathy: incidence, risk factors and pathophysiology. Curr Atheroscler Rep. 2007;9:389-396.
28. Pasternak RC, Smith SC, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. Stroke. 2002;33:2337-2341.
29. McKenney JM, Davidson MH, Jacobson TA, Guyton JR. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol. 2006;97(suppl):89C-94C.
30. Stein EA, Ballantyne CM, Windler E, et al. Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins. Am J Cardiol. 2008;101:490-496.
31. Glueck CJ, Aregawi D, Agloria M, et al. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with non-statin lipid-lowering therapies. Clin Ther. 2006;28:933-942.
32. Bays H. Statin safety: an overview and assessment of the data-2005. Am J Cardiol. 2006;97(suppl):27C-31C.
33. Huang CF, Li TC, Lin CC, et al. Efficacy of Monascus purpureus West rice on lowering lipid rations in hypercholesterolemic patients. Eur J Cardiovasc Prev Rehabil. 2007;14:438-440.
34. Ahmed W, Khan N, Glueck CJ, et al. Low serum 25 (OH) vitamin D levels (32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res. 2009;153:11-16.