LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 887-888, Issue , 2012, Pages 122-127

  Ferreiros N ^a   Labocha, S ^a   Schroder M ^a   Radeke, H H ^a   Geisslinger, G ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

FTY720; FTY720 phosphate; LC MS MS; Multiple sclerosis

Indexed keywords

ANALYTES; ANALYTICAL METHOD; ANALYTICAL PROCESS; CHROMATOGRAPHIC SYSTEMS; DEUTERATED DERIVATIVES; EUROPEAN MEDICINES AGENCIES; FOOD AND DRUG ADMINISTRATION; FTY720; HUMAN PLASMAS; INTERNAL STANDARDS; INTRACELLULAR COMPARTMENTS; LC-MS/MS; LIQUID-LIQUID EXTRACTION PROCESS; LOWER LIMITS OF QUANTITATIONS; MATRIX EFFECTS; MULTIPLE REACTION MONITORING; MULTIPLE SCLEROSIS; ORALLY ACTIVE; PHARMACOLOGICAL TREATMENT; POSITIVE ION MODE; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; SPHINGOSINE; SPLENOCYTES; SUBCELLULAR COMPARTMENTS;

LIQUID CHROMATOGRAPHY; PATIENT TREATMENT; PLASMA (HUMAN);

CHEMICAL ANALYSIS;

FINGOLIMOD; SPHINGOSINE;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMPARTMENTALIZATION; DRUG SELECTIVITY; ELECTROSPRAY; FREEZE THAWING; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTRACELLULAR FLUID; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MOUSE; NONHUMAN; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; ROOM TEMPERATURE; SPLEEN CELL; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; INTRACELLULAR SPACE; LINEAR MODELS; LIQUID-LIQUID EXTRACTION; MICE; PHOSPHORIC ACID ESTERS; PROPYLENE GLYCOLS; REPRODUCIBILITY OF RESULTS; SPHINGOSINE; SPLEEN; TANDEM MASS SPECTROMETRY;

MURINAE;

EID: 84857142084     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.01.023     Document Type: Article

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