Matrix-associated and autologous chondrocyte transplantation in the ankle: Clinical and MRI follow-up after 2 to 11 years

Cartilage

Volumn 2, Issue 1, 2011, Pages 81-91

  Nehrer, Stefan ^a   Domayer, S E ^b   Hirschfeld, Clemens ^b   Stelzeneder, David ^b   Trattnig, Siegfried ^b   Dorotka, Ronald ^b,c  

^a DANUBE UNIVERSITY KREMS   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Orthopedic City Center Vienna   (Austria)

Author keywords

3T; Aci; Ankle; Autologous chondrocyte transplantation; Cartilage repair; T2 mapping

Indexed keywords

EID: 84857134562     PISSN: 19476035     EISSN: 19476043     Source Type: Journal    
DOI: 10.1177/1947603510381095     Document Type: Article

References (60)

1. Mandelbaum BR, Gerhardt MB, Peterson L. Autologous chondrocyte implantation of the talus. Arthroscopy. 2003;19(suppl 1):129-37.
2. Ronga M, Grassi FA, Montoli C, Bulgheroni P, Genovese E, Cherubino P. Treatment of deep cartilage defects of the ankle with matrix-induced autologous chondrocyte implantation (MACI). Foot Ankle Surg. 2005;11:29-33.
3. Toth AP, Easley ME. Ankle chondral injuries and repair. Foot Ankle Clin. 2000;5:799-840.
4. Hintermann B, Boss A, Schafer D. Arthroscopic findings in patients with chronic ankle instability. Am J Sports Med. 2002;30:402-9.
5. Gomoll AH, Madry H, Knutsen G, van Dijk N, Seil R, Brittberg M, et al. The subchondral bone in articular cartilage repair: current problems in the surgical management. Knee Surg Sports Traumatol Arthrosc. 2010;18:434-47.
6. Zengerink M, Struijs PA, Tol JL, van Dijk CN. Treatment of osteochondral lesions of the talus: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2010;18:238-46.
7. Hangody L, Feczko P, Bartha L, Bodó G, Kish G. Mosaicplasty for the treatment of articular defects of the knee and ankle. Clin Orthop Relat Res. 2001;391(suppl):S328-36.
8. Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A. Autologous chondrocyte transplantation: biomechanics and long-term durability. Am J Sports Med. 2002;30:2-12.
9. Knutsen G, Drogset JO, Engebretsen L, Grøntvedt T, Isaksen V, Ludvigsen TC, et al. A randomized trial comparing autologous chondrocyte implantation with microfracture: findings at five years. J Bone Joint Surg Am. 2007;89:2105-12.
10. Knutsen G, Engebretsen L, Ludvigsen TC, Drogset JO, Grøntvedt T, Solheim E, et al. Autologous chondrocyte implantation compared with microfracture in the knee: a randomized trial. J Bone Joint Surg Am. 2004;86A:455-64.
11. Saris DB, Vanlauwe J, Victor J, Almqvist KF, Verdonk R, Bellemans J, et al. Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009;37(suppl 1):10S-19S.
12. Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36:235-46.
13. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331:889-95.
14. Giannini S, Vannini F. Operative treatment of osteochondral lesions of the talar dome: current concepts review. Foot Ankle Int. 2004;25:168-75.
15. Giannini S, Buda R, Grigolo B, Vannini F. Autologous chondrocyte transplantation in osteochondral lesions of the ankle joint. Foot Ankle Int. 2001;22:513-7.
16. Whittaker JP, Smith G, Makwana N, Roberts S, Harrison PE, Laing P, et al. Early results of autologous chondrocyte implantation in the talus. J Bone Joint Surg Br. 2005;87:179-83.
17. Giannini S, Buda R, Faldini C, Vannini F, Bevoni R, Grandi G, et al. Surgical treatment of osteochondral lesions of the talus in young active patients. J Bone Joint Surg Am. 2005;87(suppl 2):28-41.
18. Peterson L, Brittberg M, Lindahl A. Autologous chondrocyte transplantation of the ankle. Foot Ankle Clin. 2003;8:291-303.
19. Dorotka R, Kotz R, Trattnig S, Nehrer S. Mid-term results of autologous chondrocyte transplantation in knee and ankle: a one-to six-year follow-up study [in German]. Z Rheumatol. 2004;63:385-92.
20. Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A. Two-to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res. 2000;374:212-34.
21. Freed LE, Grande DA, Lingbin Z, Emmanual J, Marquis JC, Langer R. Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res. 1994;28:891-9.
22. Kim WS, Vacanti JP, Cima L, Mooney D, Upton J, Puelacher WC, et al. Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers. Plast Reconstr Surg. 1994;94:233-7; discussion 238-40.
23. Robinson D, Efrat M, Mendes DG, Halperin N, Nevo Z. Implants composed of carbon fiber mesh and bone-marrowderived, chondrocyte-enriched cultures for joint surface reconstruction. Bull Hosp Jt Dis. 1993;53:75-82.
24. Sittinger M, Reitzel D, Dauner M, Hierlemann H, Hammer C, Kastenbauer E, et al. Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes. J Biomed Mater Res. 1996;33:57-63.
25. Toolan BC, Frenkel SR, Pachence JM, Yalowitz L, Alexander H. Effects of growth-factor-enhanced culture on a chondrocyte-collagen implant for cartilage repair. J Biomed Mater Res. 1996;31:273-80.
26. Campoccia D, Doherty P, Radice M, Brun P, Abatangelo G, Williams DF. Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials. 1998;19:2101-27.
27. Aigner J, Tegeler J, Hutzler P, Campoccia D, Pavesio A, Hammer C, et al. Cartilage tissue engineering with novel nonwoven structured biomaterial based on hyaluronic acid benzyl ester. J Biomed Mater Res. 1998;42:172-81.
28. Benedetti L, Cortivo R, Berti T, Berti A, Pea F, Mazzo M, et al. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats. Biomaterials. 1993;14:1154-60.
29. Cortivo R, Brun P, Rastrelli A, Abatangelo G. In vitro studies on biocompatibility of hyaluronic acid esters. Biomaterials. 1991;12:727-30.
30. Brun P, Abatangelo G, Radice M, Zacchi V, Guidolin D, Daga Gordini D, et al. Chondrocyte aggregation and reorganization into three-dimensional scaffolds. J Biomed Mater Res. 1999;46:337-46.
31. Grigolo B, Lisignoli G, Piacentini A, Fiorini M, Gobbi P, Mazzotti G, et al. Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): molecular, immunohistochemical and ultrastructural analysis. Biomaterials. 2002;23:1187-95.
32. Pavesio A, Abatangelo G, Borrione A, Brocchetta D, Hollander AP, Kon E, et al. Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp. 2003;249:203-17; discussion 229-33, 234-38, 239-41.
33. Marcacci M, Zaffagnini S, Kon E, Visani A, Iacono F, Loreti I. Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc. 2002;10: 154-159.
34. Henderson I, Lavigne P, Valenzuela H, Oakes B. Autologous chondrocyte implantation: superior biologic properties of hyaline cartilage repairs. Clin Orthop Relat Res. 2007;455: 253-261.
35. Nehrer S, Spector M, Minas T. Histologic analysis of tissue after failed cartilage repair procedures. Clin Orthop Relat Res. 1999;365:149-162.
36. Domayer SE, Welsch GH, Dorotka R, Mamisch TC, Marlovits S, Szomolanyi P, et al. MRI monitoring of cartilage repair in the knee: a review. Semin Musculoskelet Radiol. 2008;12:302-17.
37. Welsch GH, Mamisch TC, Hughes T, Domayer S, Marlovits S, Trattnig S. Advanced morphological and biochemical magnetic resonance imaging of cartilage repair procedures in the knee joint at 3 Tesla. Semin Musculoskelet Radiol. 2008;12:196-211.
38. Trattnig S, Mamisch TC, Welsch GH, Glaser C, Szomolanyi P, Gebetsroither S, et al. Quantitative T2 mapping of matrixassociated autologous chondrocyte transplantation at 3 Tesla: an in vivo cross-sectional study. Invest Radiol. 2007;42: 442-448.
39. Welsch GH, Mamisch TC, Domayer SE, Dorotka R, Kutscha-Lissberg F, Marlovits S, et al. Cartilage T2 assessment at 3-T MR imaging: in vivo differentiation of normal hyaline cartilage from reparative tissue after two cartilage repair procedures-initial experience. Radiology. 2008;247:154-61.
40. Girotto D, Urbani S, Brun P, Renier D, Barbucci R, Abatangelo G. Tissue-specific gene expression in chondrocytes grown on three-dimensional hyaluronic acid scaffolds. Biomaterials. 2003;24:3265-75.
41. Kitaoka HB, Alexander IJ, Adelaar RS, Nunley JA, Myerson MS, Sanders M. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int. 1994;15: 349-53.
42. Wülker N, Wirth CJ, Rudert M. Die Behandlung der fibularen Kapselband-Ruptur. Eine Multicenter-Studie. Z.Orthop 1996;134:149-154.
43. Roos E. Rigorous statistical reliability, validity, and responsiveness testing of the Cincinnati Knee Rating System in 350 subjects with uninjured, injured, or anterior cruciate ligamentreconstructed knee. Am J Sports Med. 2000;28:436-8.
44. Domayer SE, Kutscha-Lissberg F, Welsch G, Dorotka R, Nehrer S, Gabler C, et al. T2 mapping in the knee after microfracture at 3.0 T: correlation of global T2 values and clinical outcome-preliminary results. Osteoarthritis Cartilage.2008;16:903-8.
45. Welsch GH, Trattnig S, Domayer S, Marlovits S, White LM, Mamisch TC. Multimodal approach in the use of clinical scoring, morphological MRI and biochemical T2-mapping and diffusion-weighted imaging in their ability to assess differences between cartilage repair tissue after microfracture therapy and matrix-associated autologous chondrocyte transplantation: a pilot study. Osteoarthritis Cartilage. 2009;17:1219-27.
46. Saxena A, Eakin C. Articular talar injuries in athletes: results of microfracture and autogenous bone graft. Am J Sports Med. 2007;35:1680-7.
47. Becher C, Driessen A, Hess T, Longo UG, Maffulli N, Thermann H. Microfracture for chondral defects of the talus: maintenance of early results at midterm follow-up. Knee Surg Sports Traumatol Arthrosc. 2010;18:656-63.
48. Giannini S, Buda R, Vannini F, Di Caprio F, Grigolo B. Arthroscopic autologous chondrocyte implantation in osteochondral lesions of the talus: surgical technique and results. Am J Sports Med. 2008;36:873-80.
49. Giannini S, Buda R, Grigolo B, Vannini F, De Franceschi L, Facchini A. The detached osteochondral fragment as a source of cells for autologous chondrocyte implantation (ACI) in the ankle joint. Osteoarthritis Cartilage. 2005;13:601-7.
50. Kangarlu A, Gahunia HK. Magnetic resonance imaging characterization of osteochondral defect repair in a goat model at 8 T. Osteoarthritis Cartilage. 2006;14:52-62.
51. Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, et al. A randomized trial comparing autologous chondrocyte implantation with microfracture: findings at five years. J Bone Joint Surg Am. 2007;89:2105-12.
52. Knutsen G, Engebretsen L, Ludvigsen TC, Drogset JO, Grontvedt T, Solheim E, et al. Autologous chondrocyte implantation compared with microfracture in the knee: a randomized trial. J Bone Joint Surg Am. 2004;86A:455-64.
53. Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36:235-46.
54. Quirbach S, Trattnig S, Marlovits S, Zimmermann V, Domayer S, Dorotka R, et al. Initial results of in vivo high-resolution morphological and biochemical cartilage imaging of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the ankle. Skeletal Radiol. 2009;38:751-60.
55. Welsch GH, Mamisch TC, Weber M, Horger W, Bohndorf K,Trattnig S. High-resolution morphological and biochemical imaging of articular cartilage of the ankle joint at 3.0 T using a new dedicated phased array coil: in vivo reproducibility study. Skeletal Radiol. 2008;37:519-26.
56. Mlynarik V, Szomolanyi P, Toffanin R, Vittur F, Trattnig S. Transverse relaxation mechanisms in articular cartilage. J Magn Reson. 2004;169:300-7.
57. Menezes NM, Gray ML, Hartke JR, Burstein D. T2 and T1rho MRI in articular cartilage systems. Magn Reson Med.2004;51:503-9.
58. Nieminen MT, Rieppo J, Toyras J, Hakumaki JM, Silvennoinen J, Hyttinen MM, et al. T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study. Magn Reson Med. 2001;46:487-93.
59. White LM, Sussman MS, Hurtig M, Probyn L, Tomlinson G, Kandel R. Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects. Radiology. 2006;241: 407-14.
60. Burstein D, Gray ML. Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis? Osteoarthritis Cartilage. 2006;14:1087-90.