Drug development from Australian elapid snake venoms and the Venomics pipeline of candidates for haemostasis: Textilinin-1 (Q8008), Haempatch™ (Q8009) and CoVase™ (V0801)

Toxicon

Volumn 59, Issue 4, 2012, Pages 456-463

  Earl, Stephen T H ^a,b   Masci, Paul P ^b   de Jersey, John ^b   Lavin, Martin F ^b,c   Dixon, Janette ^a  

^a Venomics Pty Ltd   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Australian elapid; Drug discovery; Haemostat; Snake venom; Venomics

Indexed keywords

APROTININ; BLOOD CLOTTING FACTOR 10A; COVASE; HAEMPATCH; HEMOSTATIC AGENT; PLASMA KALLIKREIN; PLASMIN INHIBITOR; PROCOAGULANT; PROTEINASE INHIBITOR; Q 8008; Q 8009; SNAKE VENOM; TEXTILININ 1; TEXTILININ 2; THROMBIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; V 0801;

BLEEDING; BLOOD CLOTTING; DRUG INDUSTRY; DRUG POTENCY; DRUG RESEARCH; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; FIBRINOLYSIS; HEMOSTASIS; NONHUMAN; PRIORITY JOURNAL; PSEUDONAJA TEXTILIS; REVIEW; SNAKE;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; AUSTRALIA; DRUG DISCOVERY; ELAPID VENOMS; ELAPIDAE; FACTOR XA; HEMORRHAGE; HEMOSTASIS; HEMOSTATICS; HUMANS; REPTILIAN PROTEINS; SERINE ENDOPEPTIDASES;

ELAPIDAE;

EID: 84857060189     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.12.010     Document Type: Review

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