Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases

Journal of the Neurological Sciences

Volumn 314, Issue 1-2, 2012, Pages 92-96

  Araki, Toshiyuki ^a   Nagano, Seiichi ^a   Tateno, Minako ^a   Kaido, Misako ^b   Ogata, Katsuhisa ^c   Arima, Kunimasa ^d  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b SAKAI MUNICIPAL HOSPITAL   (Japan)

^c Higashisaitama National Hospital   (Japan)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

Amyotrophic lateral schlerosis; L126S mutation; SOD1; Synapse

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR GLUR2; GLUTAMATE RECEPTOR GLUR3; KAP3 PROTEIN; KINESIN 2; MISFOLDED SUPEROXIDE DISMUTASE 1; MUTANT PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UNCLASSIFIED DRUG;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONTROLLED STUDY; EXCITOTOXICITY; FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS; FAMILIAL DISEASE; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; SYNAPSE VESICLE; SYNAPTIC INHIBITION; WILD TYPE;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; AUTOPSY; CELL MEMBRANE; CELLS, CULTURED; CENTRIFUGATION, DENSITY GRADIENT; DNA, COMPLEMENTARY; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PROTEOSTASIS DEFICIENCIES; SUPEROXIDE DISMUTASE; SYNAPSES;

EID: 84857059828     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2011.10.017     Document Type: Article

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