Ulcerative colitis: Evolving insights into pathogenesis

Mucosal Immunology, Two-Volume Set

Volumn , Issue , 2005, Pages 1255-1263

  Karp, Loren C ^a   Targan, Stephan R ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84857054458     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012491543-5/50075-9     Document Type: Chapter

References (63)

1. Ahmad T, Satsangi J, McGovern D, Bunce M, Jewell DP The genetics of inflammatory bowel disease [review]. Aliment. Pharmacol. Ther. 2001, 15:731-748.
2. Billing P, Tahir S, Calfin B, Gagne G, Cobb L, Targan S, Vidrich A Nuclear localization of the antigen detected by ulcerative colitis-associated perinuclear antineutrophil cytoplasmic antibodies. Am. J. Pathol. 1995, 147:979-987.
3. Bonen DK, Cho JH The genetics of inflammatory bowel disease. Gastroenterology 2003, 124:521-536.
4. Cho JH, Nicolae DL, Gold LH, Fields CT, LaBuda MC, Rohal PM, Pickles MR, Qin L, Fu Y, Mann JS, Kirschner BS, Jabs EW, Weber J, Hanauer SB, Bayless TM, Brant SR Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc. Natl. Acad. Sci. USA 1998, 95:7502-7507.
5. Cortina G, Lewin K Pathology of inflammatory bowel disease: a critical appraisal in diagnosis and management. Inflammatory Bowel Disease: From Bench to Bedside 2003, 903. Kluwer Academic Publishers, Dordrecht. S.R. Targan, F. Shanahan, L.C. Karp (Eds.).
6. Das KM, Dasgupta A, Mandal A, Geng X Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis. J. Immunol. 1993, 150:2487-2493.
7. Dieleman LA, Pena AS, Meuwissen SG, van Rees EP Role of animal models for the pathogenesis and treatment of inflammatory bowel disease. Scand. J. Gastroenterol. Suppl. 1997, 223:99-104.
8. Dubuquoy L, Jansson EA, Deeb S, Rakotobe S, Karoui M, Colombel JF, Auwerx J, Pettersson S, Desreumaux P Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology 2003, 124:1265-1276.
9. Duerr RH, Chensny LJ, Wong CT, Neigut DA Homozygosity of an HLA Class II group haplotype is associated with pANCA-positive and familial ulcerative colitis. Gastroenterology 1995, 108:A812.
10. Duerr RH, Neigut DA Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup. Gastroenterology 1995, 108:423-427.
11. Eggena MP, Targan SR, Vidrich A, Clemons DF, Iwanczyk L, Braun J Histone H1: The UC-specific pANCA target antigen. FASEB J. 1996, 10:463.
12. Ekbom A The changing faces of Crohn's disease and ulcerative colitis. Inflammatory Bowel Disease From Bench to Bedside 2003, Kluwer Academic Publishers, Dordrecht. S.R. Targan, F. Shanahan, L.C. Karp (Eds.).
13. Elson CO, Sartor RB, Tennyson GS, Riddell RH Experimental models of inflammatory bowel disease. Gastroenterology 1995, 109:1344-1367.
14. Fleshner PR, Vasiliauskas EA, Kam LY, Fleshner NE, Gaiennie J, Abreu-Martin MT, Targan SR High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis. Gut 2001, 49:671-677.
15. Fuss IJ, Strober W, Dale JK, Fritz S, Pearlstein GR, Puck JM, Lenardo MJ, Straus SE Characteristic T helper 2 T cell cytokine abnormalities in autoimmune lymphoproliferative syndrome, a syndrome marked by defective apoptosis and humoral autoimmunity. J. Immunol. 1997, 158:1912-1918.
16. Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P, Vitali B, Poggioli G, Miglioli M, Campieri M Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 2003, 124:1202-1209.
17. Gordon LK, Eggena M, Targan SR, Braun J Definition of ocular antigens in ciliary body and retinal ganglion cells by the marker antibody pANCA. Invest. Ophthalmol. Vis. Sci. 1999, 40:1250-1255.
18. Halstensen TS, Das KM, Brandtzaeg P Epithelial deposits of immunoglobulin G1 and activated complement co-localize with the "M(r) 40kD" putative auto-antigen in ulcerative colitis. Adv. Exp. Med. Biol. 1995, 371B:1273-1276.
19. Hampe J, Schreiber S, Shaw SH, Lau KF, Bridger S, Macpherson AJ, Cardon LR, Sakul H, Harris TJ, Buckler A, Hall J, Stokkers P, van Deventer SJ, Nurnberg P, Mirza MM, Lee JC, Lennard-Jones JE, Mathew CG, Curran ME A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am. J. Hum. Genet. 1999, 64:808-816.
20. Heller F, Boirivant M, Mannon P, Blumberg RS, Nieuwenhuis EE, Strober W, Fuss IJ IL-13 secretion by CD4+CD161+NK-T cells is increased in oxazolone and human ulcerative colitis (UC). Gastroenterology 2003, 124:A35.
21. Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002, 17:629-638.
22. Hornquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J. Immunol. 1997, 158:1068-1077.
23. Iqbal N, Oliver JR, Wagner FH, Lazenby AS, Elson CO, Weaver CT T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J. Exp. Med. 2002, 195:71-84.
24. Kirsner JB, Shorter RG Inflammatory Bowel Disease 1995, Williams & Wilkins, Baltimore.
25. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75:263-274.
26. Lashner BA Epidemiology of inflammatory bowel disease. Gastroenterol. Clin. North Am. 1995, 24:467-474.
27. Lohmuller JL, Pemberton JH, Dozois RR, Ilstrup D, van Heerden J Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis. Ann. Surg. 1990, 211:622-627. discussion 627-629.
28. Ma Y, Ohmen JD, Li Z, Bentley LG, McElree C, Pressman S, Targan SR, Fischel-Ghodsian N, Rotter JI, Yang H A genomewide search identifies potential new susceptibility loci for Crohn's disease. Inflamm. Bowel Dis. 1999, 5:271-278.
29. Mansfield JC, Holden H, Tarlow JK, Di Giovine FS, McDowell TL, Wilson AG, Holdsworth CD, Duff GW Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994, 106:637-642.
30. Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice. J. Exp. Med. 1996, 184:707-715.
31. Mizoguchi A, Mizoguchi E, Chiba C, Spiekermann GM, Tonegawa S, Nagler-Anderson C, Bhan AK Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. J. Exp. Med. 1996, 183:847-856.
32. Mizoguchi A, Mizoguchi E, Smith RN, Preffer FI, Bhan AK Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J. Exp. Med. 1997, 186:1749-1756.
33. Mizoguchi E, Mizoguchi A, Chiba C, Niles JL, Bhan AK Antineutrophil cytoplasmic antibodies in T-cell receptor alpha-deficient mice with chronic colitis. Gastroenterology 1997, 113:1828-1835.
34. Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993, 75:274-282.
35. Natori H, Utsunomiya J, Yamamura T, Benno Y, Uchida K Fecal and stomal bile acid composition after ileostomy or ileoanal anastomosis in patients with chronic ulcerative colitis and adenomatosis coli. Gastroenterology 1992, 102:1278-1288.
36. Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc. Natl. Acad. Sci. USA 2002, 99:16951-16956.
37. Omata F, Birkenbach M, Matsuzaki S, Christ AD, Blumberg RS The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease. Inflamm. Bowel Dis. 2001, 7:215-220.
38. Orchard TR, Thiyagaraja S, Welsh KI, Wordsworth BP, Hill Gaston JS, Jewell DP Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease. Gastroenterology 2000, 118:274-278.
39. Podolsky DK Inflammatory bowel disease (1). N. Engl. J. Med. 1991, 325:928-937.
40. Podolsky DK Inflammatory bowel disease (2). N. Engl. J. Med. 1991, 325:1008-1016.
41. Powrie F T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995, 3:171-174.
42. Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am. J. Hum. Genet. 2000, 66:1863-1870.
43. Roussomoustakaki M, Satsangi J, Welsh K, Louis E, Fanning G, Targan S, Landers C, Jewell DP Genetic markers may predict disease behavior in patients with ulcerative colitis. Gastroenterology 1997, 112:1845-1853.
44. Rutgeerts P, D'Haens G, Hiele M, Geboes K, Vantrappen G Appendectomy protects against ulcerative colitis. Gastroenterology 1994, 106:1251-1253.
45. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993, 75:253-261.
46. Sandborn WJ Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis, and treatment. Gastroenterology 1994, 107:1856-1860.
47. Satsangi J, Jewell DP, Rosenberg WM, Bell JI Genetics of inflammatory bowel disease. Gut 1994, 35:696-700.
48. Satsangi J, Landers CJ, Welsh KI, Koss K, Targan S, Jewell DP The presence of anti-neutrophil antibodies reflects clinical and genetic heterogeneity within inflammatory bowel disease. Inflamm. Bowel Dis. 1998, 4:18-26.
49. Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, Terwilliger JD, Lathrop GM, Bell JI, Jewell DP Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat. Genet. 1996, 14:199-202.
50. Satsangi J, Welsh KI, Bunce M, Julier C, Farrant JM, Bell JI, Jewell DP Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 1996, 347:1212-1217.
51. Saxon A, Shanahan F, Landers C, Ganz T, Targan S A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J. Allergy Clin. Immunol. 1990, 86:202-210.
52. Seibold F, Slametschka D, Gregor M, Weber P Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1994, 107:532-536.
53. Shanahan F, Duerr RH, Rotter JI, Yang H, Sutherland LR, McElree C, Landers CJ, Targan SR Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology 1992, 103:456-461.
54. Shapiro BD, Lashner BA Cancer biology in ulcerative colitis and potential use in endoscopic surveillance. Gastrointest. Endosc. Clin. N. Am. 1997, 7:453-468.
55. Targan S, Shanahan F Inflammatory Bowel Disease: From Bench to Bedside 1994, Williams & Wilkins.
56. Targan SR, Landers CJ, Cobb L, MacDermott RP, Vidrich A Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients. J. Immunol. 1995, 155:3262-3267.
57. Targan SR, Shanahan F, Karp LC Inflammatory Bowel Disease: From Bench to Bedside 2004, Kluwer Academic Publishers, Dordrecht.
58. Taylor KD, Rotter JI, Yang HY Genetics of inflammatory bowel disease. Inflammatory Bowel Disease: From Bench to Bedside 2003, 21-65. Kluwer Academic Publishers, Dordrecht. S.R. Targan, F. Shanahan, L.C. Karp (Eds.).
59. Toyoda H, Wang SJ, Yang HY, Redford A, Magalong D, Tyan D, McElree CK, Pressman SR, Shanahan F, Targan SR, et al. Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology 1993, 104:741-748.
60. van Heel DA, Carey AH, Jewell DP Identification of novel polymorphisms in the beta7 integrin gene: family-based association studies in inflammatory bowel disease. Genes Immun. 2001, 2:455-460.
61. Vanderlugt CJ, Miller SD Epitope spreading. Curr. Opin. Immunol. 1996, 8:831-836.
62. Vidrich A, Lee J, James E, Cobb L, Targan S Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis. J. Clin. Immunol. 1995, 15:293-299.
63. Yang H, Rotter JI, Toyoda H, Landers C, Tyran D, McElree CK, Targan SR Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers. J. Clin. Invest. 1993, 92:1080-1084.