Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents

Phytomedicine

Volumn 19, Issue 3-4, 2012, Pages 369-373

  Sun, Dong ^a   Wang, Bing ^a   Shi, Ming ^a   Zhang, Yun Xia ^a   Zhou, Lin Fu ^a   Liu, Zhi Rong ^a   Wu, Zhong Liang ^a   Jiang, Wen ^a   Han, Jun Liang ^a   Xiong, Li Ze ^a   Zhao, Gang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Excretion; Ginsenoside Rd; Pharmacokinetic; Rodents; Tissue distribution

Indexed keywords

GINSENOSIDE RD;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FEMALE; GINSENOSIDES; HYDROGEN; LINEAR MODELS; LIVER; LUNG; MALE; MICE; PANAX; PLASMA; RADIOACTIVE TRACERS; RADIOISOTOPES; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

ANIMALIA; MUS; PANAX GINSENG; RATTUS; RODENTIA;

EID: 84857049075     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.08.061     Document Type: Article

References (10)

1. A.M. Bots, W.J. Van Oort, J. Noordhoek, A. Van Dijk, S.W. Klein, Q.G. Van, and Hoesel Analysis of adriamycin and adriamycinol in micro volumes of rat plasma J. Chromatogr. 272 2 1983 421 427 (Pubitemid 13149637)
2. B.X. Cai, X.Y. Li, J.H. Chen, Y.B. Tang, G.L. Wang, J.G. Zhou, Q.Y. Qui, and Y.Y. Guan. Ginsenoside-Rd, a new voltage-independent Ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats Eur. J. Pharmacol. 606 1-3 2009 142 149
3. H. Dang, Y. Chen, X. Liu, Q. Wang, L. Wang, W. Jia, and Y. Wang. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression Prog. Neuropsychopharmacol. Biol. Psychiatry 33 8 2009 1417 1424
4. D.O. Kennedy, and A.B. Scholey Ginseng: potential for the enhancement of cognitive performance and mood Pharmacol. Biochem. Behav. 75 3 2003 687 700 (Pubitemid 36939174)
5. Y. Kou, Y. Liu, M. Xue, Y. Xu, H. Liu, J. Ruan, and K. Liu. Comparative pharmacokinetics and distribution kinetics in brain of phencynonate enantiomers in rats Int. J. Pharm. 353 1-2 2008 88 94
6. X. Liu, J. Xia, L. Wang, Y. Song, J. Yang, Y. Yan, H. Ren, and G. Zhao. Efficacy and safety of ginsenoside-Rd for acute ischaemic stroke: a randomized, double-blind, placebo-controlled, phase II multicenter trial Eur. J. Neurol. 16 5 2009 569 575
7. Q. Shi, Q. Hao, J. Bouissac, Y. Lu, S. Tian, and B. Luu. Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells Life Sci. 76 9 2005 983 995 (Pubitemid 39643399)
8. T. Tamura, X. Cui, N. Sakaguchi, and M. Akashi Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis Food Chem. Toxicol. 46 9 2008 3080 3089
9. R. Ye, J. Han, X. Kong, L. Zhao, R. Cao, Z. Rao, and G. Zhao. Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide Biol. Pharm. Bull. 31 10 2008 1923 1927
10. R. Ye, N. Li, J. Han, X. Kong, R. Cao, Z. Rao, and G. Zhao. Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons Neurosci. Res. 64 3 2009 306 310