Perinatal outcomes, mitochondrial toxicity and apoptosis in HIV-treated pregnant women and in-utero-exposed newborn

AIDS

Volumn 26, Issue 4, 2012, Pages 419-428

  Hernàndez, Sandra ^a,b,c,d   Morén, Constanza ^b,c,d   López, Marta ^a   Coll, Oriol ^a   Cardellach, Francesc ^b,c,d   Gratacós, Eduard ^a   Miró, Òscar ^b,c,d   Garrabou, Glòria ^b,c,d  

^a Clinical Institute of Gynaecology Obstetrics and Neonatology   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

antiretroviral treatment; apoptosis; HIV; infants; mitochondrial DNA; mitochondrial toxicity; pregnancy

Indexed keywords

ANTIRETROVIRUS AGENT; BETA ACTIN; CASPASE 3; GLYCEROL KINASE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; RNA 18S;

ADULT; APOPTOSIS; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MATERNAL BLOOD; MITOCHONDRIAL TOXICITY; MONONUCLEAR CELL; NEWBORN; OBSERVATIONAL STUDY; PREGNANCY; PREGNANCY OUTCOME; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SMALL FOR DATE INFANT; UMBILICAL CORD BLOOD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; APOPTOSIS; BLOTTING, WESTERN; CROSS-SECTIONAL STUDIES; DNA, MITOCHONDRIAL; FEMALE; FETAL BLOOD; HIV INFECTIONS; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LEUKOCYTES, MONONUCLEAR; MATERNAL-FETAL EXCHANGE; ODDS RATIO; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY OUTCOME; PREMATURE BIRTH; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES;

EID: 84857044053     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834f3232     Document Type: Article

References (37)

1. Volmink J, Siegfried NL, van der Merwe L, Brocklehurst P. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database Syst Rev 2007; CD003510.
2. Watts DH. Management of human immunodeficiency virus infection in pregnancy. N Engl J Med 2002; 346:1879-1891.
3. Public Health Service Task Force. Recommendations for the use of antiretroviral drugs in pregnant HIV-1 infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States.MWWRSeptember 22, 2003.
4. Sturt AS, Dokubo EK, Sint TT. Antirretroviral therapy for treating HIV infection in ART-eligible pregnant women. Cochrane Database Syst Rev 2010; CD0008440.
5. Brocklehurst P, French R. The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and metaanalysis. Br J Obstet Gynaecol 1998; 105:836-848. (Pubitemid 28423498)
6. ThorneC,PatelD,NewellML.Increasedriskofadversepregnancy outcomes in HIV-infected women treated with highly active antiretroviral therapy in Europe. AIDS 2004; 18:2337-2339. (Pubitemid 39620231)
7. Tuomala RE, Shapiro DE, Mofenson LM, Bryson Y, Culnane M, Hughes MD, et al. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med 2002; 346:1863-1870. (Pubitemid 34603030)
8. Tuomala RE, Watts DH, Li D, Vajaranant M, Pitt J, Hammill H, et al. Improved obstetric outcomes and few maternal toxicities are associated with antiretroviral therapy, including highly active antiretroviral therapy during pregnancy. J Acquir Immune Defic Syndr 2005; 38:449-473. (Pubitemid 40381556)
9. Lambert JS, Watts DH, Mofenson L, Stiehm ER, Harris DR, Bethel J, et al. Risk factors for preterm birth, low birth weight, and intrauterine growth retardation in infants born to HIVinfected pregnant women receiving zidovudine. Pediatric AIDS Clinical Trials Group 185 Team. AIDS 2000; 14:1389-1399. (Pubitemid 30459512)
10. Suy A, Martinez E, Coll O, Lonca M, Palacio M, de Lazzari E, et al. Increased risk of preeclampsia and fetal death in HIVinfected pregnant women receiving highly active antiretroviral therapy. AIDS 2006; 20:59-66. (Pubitemid 41818115)
11. Wimalasundera RC, Larbalestier N, Smith JH, de Ruiter A, McG Thom SA, Hughes AD, et al. Preeclampsia, antiretroviral therapy, and immune reconstitution. Lancet 2002; 360:1152-1154. (Pubitemid 35246493)
12. Rudin C, Spaenhauer A, Keiser O, Rickenbach M, Kind C, Aebi-Popp K, et al. Antiretroviral therapy during pregnancy and premature birth:analysis ofSwiss data. HIVMed2011; 12:228-235.
13. Haeri S, Shauer M, Dale M, Leslie J, Baker AM, Saddlemire S, Boggess K. Obstetric and newborn infant outcomes in human immunodeficiency virus-infected women who receive highly active antiretroviral therapy. Am J Obstet Gynecol 2009; 201:315.e1-315.e5.
14. Townsend CL, Cortina-Borja M, Peckham CS, Tookey PA. Antiretroviral therapy and premature delivery in diagnosed HIV-infected women in the United Kingdom and Ireland. AIDS 2007; 21:1019-1026. (Pubitemid 46684333)
15. Szyld EG, Warley EM, Freimanis L, Gonin R, Cahn PE, Calvet GA, et al. Pregnancy outcome in women infected with HIV-1 receiving combination antiretroviral therapy before versus after conception. AIDS 2006; 20:2345-2353.
16. Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med 1995; 1:417-422.
17. Lopez S, Coll O, Durban M, Hernàndez S, Vidal R, Suy A, et al. Mitochondrial DNA depletion in oocytes of HIV-infected antiretroviral-treated infertile women. Antivir Ther 2008; 13:833-838.
18. Garrabou G, Morén C, Gallego-Escudero JM, Milinkovic A, Villarroya F, Negredo E, et al. Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia. J Acquir Immune Defic Syndr 2009; 52:443-451.
19. Miró O, López S, Mart?́nez E, Pedrol E, Milinkovic A, Deig E, et al. Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals. Clin Infect Dis 2004; 39:710-716. (Pubitemid 39180445)
20. Yao XJ, Mouland AJ, Subbramanian RA, Forget J, Rougeau N, Bergeron D, Cohen EA. Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells. J Virol 1998; 72:4686-4693. (Pubitemid 28215643)
21. Wan ZT, Chen XL. Mechanisms of HIV envelope-induced T lymphocyte apoptosis. Virol Sin 2010; 25:307-315.
22. Hooker DJ, Gorry PR, Ellett AM, Wesselingh SL, Cherry CL. Measuring and monitoring apoptosis and drug toxicity in HIV patients by ligation-mediated polymerase chain reaction. J Cell Mol Med 2009; 13:948-958.
23. Gerschenson M, Nguyen V, Ewings EL, Ceresa A, Shaw JA, St Claire MC, et al. Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine. AIDS Res Hum Retroviruses 2004; 20:91-100. (Pubitemid 38147180)
24. Blanche S, Tardieu M, Rustin P, Slama A, Barret B, Firtion G, et al. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet 1999; 354:1084-1089. (Pubitemid 29452821)
25. Barret B, Tardieu M, Rustin P, Lacroix C, Chabrol B, Desguerre I, et al. Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: clinical screening in a large prospective cohort. AIDS 2003; 17:1769-1785. (Pubitemid 37000095)
26. Divi RL, Walker VE, Wade NA, Nagashima K, Seilkop SK, Adams ME, et al. Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to combivir. AIDS 2004; 18:1013-1021. (Pubitemid 38591192)
27. Aldrovandi GM, Chu C, Shearer WT, Li D, Walter J, Thompson B, et al. Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics 2009; 124:e1189-e1197.
28. Poirier MC, Divi RL, Al-Harthi L, Olivero OA, Nguyen V, Walker B, et al. Long-term mitochondrial toxicity in HIVuninfected infants born to HIV-infected mothers. J Acquir Immune Defic Syndr 2003; 33:175-183. (Pubitemid 36793152)
29. Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, et al. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. J Acquir Immune Defic Syndr 2003; 32:370-374. (Pubitemid 36363149)
30. Vigano A, Bianchi R, Schneider L, Cafarelli L, Tornaghi R, Pinti M, et al. Lack of hyperlactatemia and impaired mitochondrial DNA content in CD4Rcells of HIV-uninfected infants exposed to perinatal antiretroviral therapy. In: 11th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA; 2004.
31. Cote HC, Raboud J, Bitnun A, Alimenti A, Money DM, Maan E, et al. Perinatal exposure to antiretroviral therapy is associated with increased blood mitochondrial DNA levels and decreased mitochondrial gene expression in infants. J Infect Dis 2008; 198:851-859.
32. McComsey GA, Kang M, Ross AC, Lebrecht D, Livingston E, Melvin A, et al. Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy. HIV Clin Trials 2008; 9:126-136. (Pubitemid 351804396)
33. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-254.
34. Rustin P, Chretien D, Bourgeron T, Gérard B, Rö tig A, Saudubray JM, Munnich A. Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 1994; 228: 35-42.
35. Miró Ò , Cardellach F, Barrientos A, Casademont J, Rö tig A, Rustin P. Cytochrome c oxidase assay in minute amounts of human skeletal muscle using single wavelength spectrophotometers. J Neurosci Methods 1998; 80:107-111. (Pubitemid 28189519)
36. Poirier MC, Patterson TA, Slikker W Jr, Olivero OA. Incorporation of 30-azido-30-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT dose. J Acquir Immune Defic Syndr 1999; 22:477-483. (Pubitemid 30027498)
37. Gemma C, Sookoian S, Alvariñas J, Garc?́a SI, Quintana L, Kanevsky D, et al. Mitochondrial DNA depletion in smalland large-for- gestational-age newborns. Obesity (Silver Spring) 2006; 14:2193-2199. (Pubitemid 46121975)