Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection

International Journal of Antimicrobial Agents

Volumn 39, Issue 3, 2012, Pages 259-262

  Cobo, Eduardo R ^a   Reed, Sharon L ^a,b   Corbeil, Lynette B ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UCSD MEDICAL CENTER   (United States)

Author keywords

Cysteine proteinase inhibitors; Trichomonad cysteine proteinase; Tritrichomonas foetus

Indexed keywords

CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; K 11777; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; N [N (3 TRANSCARBOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; N METHYLPIPERAZINEUREAPHENYLALANYLHOMOPHENYLALANYLVINYLSULFONEBENZENE; UNCLASSIFIED DRUG; VINYL SULFONE INHIBITOR; WRR 483;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; FEMALE; GENITAL TRACT INFECTION; HOST CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTOZOAL INFECTION; TRITRICHOMONAS FOETUS; TRITRICHOMONAS FOETUS INFECTION; TROPHOBLAST;

ANIMALS; APOPTOSIS; COCULTURE TECHNIQUES; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; ENZYME ACTIVATION; FEMALE; GENITAL DISEASES, FEMALE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; OLIGOPEPTIDES; PARASITIC SENSITIVITY TESTS; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; SULFONES; TRICHOMONAS INFECTIONS; TRITRICHOMONAS FOETUS; TROPHOBLASTS; TROPHOZOITES; VINYL COMPOUNDS;

EID: 84857039926     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.09.026     Document Type: Article

References (16)

1. I.M. Parsonson, B.L. Clark, and J.H. Dufty Early pathogenesis and pathology of Tritrichomonas foetus infection in virgin heifers J Comp Pathol 86 1976 59 66
2. R.N. Fichorova Impact of T. vaginalis infection on innate immune responses and reproductive outcome J Reprod Immunol 83 2009 185 189
3. J.A. Talbot, K. Nielsen, and L.B. Corbeil Cleavage of proteins of reproductive secretions by extracellular proteinases of Tritrichomonas foetus Can J Microbiol 37 1991 384 390
4. B.N. Singh, G.R. Hayes, J.J. Lucas, D.H. Beach, and R.O. Gilbert In vitro cytopathic effects of a cysteine protease of Tritrichomonas foetus on cultured bovine uterine epithelial cells Am J Vet Res 66 2005 1181 1186 (Pubitemid 41150554)
5. B.N. Singh, J.J. Lucas, G.R. Hayes, I. Kumar, D.H. Beach, and M. Frajblat Tritrichomonas foetus induces apoptotic cell death in bovine vaginal epithelial cells Infect Immun 72 2004 4151 4158 (Pubitemid 38821930)
6. D.J. Mallinson, J. Livingstone, K.M. Appleton, S.J. Lees, G.H. Coombs, and M.J. North Multiple cysteine proteinases of the pathogenic protozoon Tritrichomonas foetus: identification of seven diverse and differentially expressed genes Microbiology 141 1995 3077 3085 (Pubitemid 26011346)
7. J.W. Thomford, J.A. Talbot, J.S. Ikeda, and L.B. Corbeil Characterization of extracellular proteinases of Tritrichomonas foetus J Parasitol 82 1996 112 117 (Pubitemid 26087515)
8. M.H. Abdulla, K.C. Lim, M. Sajid, J.H. McKerrow, and C.R. Caffrey Schistosoma mansoni: novel chemotherapy using a cysteine protease inhibitor PLoS Med 4 2007 e14
9. Y.T. Chen, L.S. Brinen, I.D. Kerr, E. Hansell, P.S. Doyle, and J.H. McKerrow In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi PLoS Negl Trop Dis 4 2010 pii: e825
10. H. Mahmoudzadeh-Niknam, and J.H. McKerrow Leishmania tropica: cysteine proteases are essential for growth and pathogenicity Exp Parasitol 106 2004 158 163 (Pubitemid 38686285)
11. C. He, G.P. Nora, E.L. Schneider, I.D. Kerr, E. Hansell, and K. Hirata A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target J Biol Chem 285 2010 18516 18527
12. G.K. Mutwiri, and L.B. Corbeil Genital and systemic immune responses in a murine model of Tritrichomonas foetus infection J Parasitol 84 1998 321 327 (Pubitemid 28217409)
13. E.R. Cobo, L. Eckmann, and L.B. Corbeil Murine models of vaginal trichomonad infections Am J Trop Med Hyg 85 2011 667 673
14. S.A. Kania, S.L. Reed, J.W. Thomford, R.H. BonDurant, K. Hirata, and R.R. Corbeil Degradation of bovine complement C3 by trichomonad extracellular proteinase Vet Immunol Immunopathol 78 2001 83 96 (Pubitemid 32140949)
15. R. Arroyo, and J.F. Alderete Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells Infect Immun 57 1989 2991 2997 (Pubitemid 19240064)
16. L.B. Corbeil, L. Munson, C. Campero, and R.H. BonDurant Bovine trichomoniasis as a model for development of vaccines against sexually-transmitted disease Am J Reprod Immunol 45 2001 310 319 (Pubitemid 32466110)