17β-Arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 4, 2012, Pages 1535-1544

  Mostafa, Yaser A ^a   Taylor, Scott D ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Breast cancer; Enzyme inhibitors; Hormone therapy; Inhibitors; Steroid sulfatase; Steroids

Indexed keywords

17ALPHA TOLUENESULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (2' N BROMOBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (3' N BROMOBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (3' N CHLOROBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' METHYLBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' METHYLBENZYL)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' N BROMOBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' N BUTYLBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' N PENTYLBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' N PHENOXYBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' N PHENYLBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' N PROPYLBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA (4' PROPYLBENZENE)SULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA 2' NAPHTHALENESULFONAMIDE DERIVATIVE; 17BETA 2' NAPHTHYLSULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA 2' PHENYLBENZENESULFONAMIDE DERIVATIVE; 17BETA AMINOESTRA 1,3,5(10) TRIEN 3 OL; 17BETA ARYLSULFONAMIDE DERIVATIVE; 17BETA BENZENESULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA BENZENESULFONAMIDE DERIVATIVE; 17BETA BENZYLSULFONAMIDE 1,3,5(10) ESTRATRIEN 3 OL; 17BETA TOLUENESULFONAMIDE DERIVATIVE; 17BETA TOLUENESULFONYLOXYESTRA 1,3,5(10) TRIEN 17BETA OL; 3 BENZYLOXY 17BETA TOLUENESULFONYLESTRA 1,3,5(10) TRIEN 17BETA OL; 3 BENZYLOXYESTRA 1,3,5(10) TRIEN 17BETA OL; ALKYL GROUP; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; STEROID SULFATASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; IC 50;

ARYLSULFATASES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; STERYL-SULFATASE; SULFONAMIDES;

EID: 84857034892     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.036     Document Type: Article

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