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Volumn 20, Issue 4, 2012, Pages 1442-1460

Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation

(12) Hada, Kihito a,b Suda, Atsushi a Asoh, Kohsuke a Tsukuda, Takuo a Hasegawa, Masami a Sato, Yasuko a Ogawa, Kotaro a Kuramoto, Shino a Aoki, Yuko a Shimma, Nobuo a Ishikawa, Tsutomu b Koyano, Hiroshi a

a CHUGAI PHARMACEUTICAL CO LTD (Japan)

b CHIBA UNIVERSITY (Japan)

Author keywords

3 (E) styryl benzamide; Angiogenesis; Endothelial cell; HUVEC

Indexed keywords

1 [3 [(4 CHLOROPHENOXY)METHYL] 4 METHOXYPHENYL]ETHANONE; 1 [4 METHOXY 3 [(3 METHYLPHENOXY)METHYL]PHENYL]ETHANONE; 1 CHLORO 4 [(5 ETHYL 2 METHOXYPHENYL)METHOXY] 2 METHYLBENZENE; 3 (DIETHOXYPHOSPHORYLMETHYL) 4 METHOXYBENZAMIDE; 3 (DIETHOXYPHOSPHORYLMETHYL) 4 METHOXYBENZOIC ACID; 3 [(4 CHLORO 3 METHYLPHENOXY)METHYL] 4 METHOXYBENZAMIDE; 3 [(4 CHLORO 3 METHYLPHENOXY)METHYL] 4 METHOXYBENZONITRILE; 3 [(4 CHLORO 3 METHYLPHENOXY)METHYL]BENZONITRILE; 3 [(4 CHLORO 3 METHYLPHENOXYMETHYL)] 4 METHOXYBENZOIC ACID; 3 [(4 CHLOROPHENOXY)METHYL] 4 METHOXYBENZAMIDE; 3 [(4 CHLOROPHENYL)CARBAMOYL] 4 METHOXYBENZOIC ACID; 3 [2 (4 BROMOPHENYL)VINYL] 4 METHOXYBENZAMIDE; 3 [2 (4 TERT BUTYLPHENYL)VINYL] 4 METHOXYBENZAMIDE; 3 [STYRYL]BENZAMIDE DERIVATIVE; 4 METHOXY 3 [2 (4 TOLYL)VINYL]BENZAMIDE; 5 ETHOXYCARBONYL 2 METHOXYBENZOIC ACID; ANGIOGENESIS INHIBITOR; BENZAMIDE DERIVATIVE; ETHYL 3 (CHLOROMETHYL) 4 METHOXYBENZOIC ACID; ETHYL 3 (DIETHOXYPHOSPHORYLMETHYL) 4 METHOXYBENZOIC ACID; ETHYL 3 [(4 CHLORO 3 METHYLPHENOXYMETHYL)] 4 METHOXYBENZOIC ACID; ETHYL 3 [(4 CHLOROPHENOXYMETHYL)] 4 METHOXYBENZOIC ACID; ETHYL 3 [(4 CHLOROPHENYL)CARBAMOYL] 4 METHOXYBENZOIC ACID; ETHYL 3 [2 (4 CHLOROPHENYL)VINYL] 4 METHOXYBENZOIC ACID; ETHYL 3 FORMYL 4 HYDROXYBENZOIC ACID; ETHYL 3 FORMYL 4 METHOXYBENZOIC ACID; METHYL 3 [(4 CHLORO 3 METHYLPHENOXY)METHYL] 4 METHOXYBENZOIC ACID; RO 0123743; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL DENSITY; CELL PROLIFERATION; CHIRALITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENDOTHELIUM CELL; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MAXIMUM PLASMA CONCENTRATION; MELTING POINT; MICROVASCULATURE; MOUSE; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; BENZYL COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOTHELIAL CELLS; HUMANS; PHENYL ETHERS; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84857033040 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.12.058 Document Type: Article

Times cited : (13)

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