Histopathological features of the brain, liver, kidney and spleen following an innovative polytrauma model of the mouse

Experimental and Toxicologic Pathology

Volumn 64, Issue 3, 2012, Pages 133-139

  Mirzayan, M J ^a   Probst, C ^a   Samii, M ^b   Krettek, C ^a   Gharabaghi, A ^c   Pape, H C ^d   Van Griensven, M ^e   Samii, A ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b INTERNATIONAL NEUROSCIENCE INSTITUTE   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

Author keywords

Brain injury; Controlled cortical impact; Fracture; Mouse; Neuroprotection; Neurotrauma; Polytrauma

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN DAMAGE; BRAIN EDEMA; BRAIN INJURY; BRAIN REGION; CELL DAMAGE; CELL DENSITY; CONTROLLED STUDY; CYTOARCHITECTURE; DISEASE ASSOCIATION; DISEASE SEVERITY; EXPERIMENTAL MOUSE; FEMUR FRACTURE; GRANULOCYTE; GRANULOCYTE FUNCTION; HEMORRHAGIC SHOCK; HEPATOMEGALY; HISTOPATHOLOGY; KIDNEY EXAMINATION; LIVER DISEASE; LIVER EXAMINATION; LUNG EDEMA; LUNG EXAMINATION; MALE; MOUSE; MULTIPLE TRAUMA; NEUTROPHIL CHEMOTAXIS; NONHUMAN; SPLEEN EXAMINATION;

ANIMALS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MULTIPLE TRAUMA; SHOCK; SHOCK, HEMORRHAGIC; SPLEEN;

ANIMALIA; MUS;

EID: 84857031947     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.07.007     Document Type: Article

References (30)

1. Abraham E., Carmody A., Shenkar R., Arcaroli J. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 2000, 279:L1137-L1145.
2. Asano T., Koide T., Gotoh O., Joshita H., Hanamura T., Shigeno T., et al. The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema. Mol Chem Neuropathol 1989, 10:101-133.
3. Boogs D. Physiology of neutrophil proliferation, maturation and circulation. Clin Haematol 1975, 4:535-551.
4. Campbell S., Zahid I., Losey P., Law S., Jiang Y., Bilgen M., et al. Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord. Neuropharmacology 2008, 55:780-787.
5. Clifton G., Ziegler M., Grossmann R. Circulating catecholamines and sympathetic activity after head injury. Neurosurgery 1981, 8:10-14.
6. Cortez S., McIntosh T., Noble L. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res 1989, 482:271-282.
7. Crittenden D., Beckman D. Traumatic head injury and pulmonary damage. J Trauma 1982, 22:766-769.
8. Davis J., Albert J., Tracy K., Calvano S., Lowry S., Shires G., et al. Increased neutrophil mobilization and decreased chemotaxis during cortisol and epinephrine infusions. J Trauma 1991, 31:725-731.
9. Garcia-Uria J., Hoff J., Miranda S., Nishimura M. Experimental neurogenic pulmonary edema. Part 2. The role of cardiopulmonary pressure change. J Neurosurg 1981, 54:632-636.
10. Haljamäe H. Organ specific metabolic changes in shock. Prog Clin Biol Res 1988, 264:17-26.
11. Hallam T., Floyd C., Folkerts M., Lee L., Gong Q., Lyeth B., et al. Comparison of behavioral defeicits and acute neuronal degeneration in rat lateral fluid percussion and weight-drop brain injury models. J Neurotrauma 2004, 21:521-539.
12. Hiltunen A., Vuorio E., Aro H. A standardized experimental fracture in the mouse tibia. J Orthop Res 1993, 11:305-312.
13. Hinshaw L. Sepsis/septic shock: participation of the microcirculation: an abbreviated review. Crit Care Med 1996, 24:1072-1078.
14. Hofstetter T., Mirzayan M.J., Krauss J.K. Ventriculo-peritoneal shunt dysfunction presenting with neurogenic pulmonary edema. J Neurosurg 2007, 106:701-703.
15. Jiang J., Tian K., Diao Y., Chen H., Zhu P., Wang Z. Expression of TNF alpha, IL-1 beta, IL-6 mRNA, release of TNF alpha in vital organs and their relationship with endotoxin in translocation following hemorrhagic shock. Chin Med Sci J 1997, 12:41-46.
16. Kontos H., Povlishock J. Oxygen radicals in brain injury. Cent Nerv Syst Trauma 1986, 3:257-263.
17. Maron M., Dawson C. Adrenal component to pulmonary hypertension induced by elevated cerebrospinal fluid pressure. J Appl Physiol 1979, 47:153-160.
18. Mirzayan M.J., Probst C., Krettek C., Samii M., Pape H.C., van Griensven M., et al. Systemic effects of isolated brain injury. An experimental animal study. Neurol Res 2008, 30:457-460.
19. Morken J., Warren K., Xie Y., Rodriguez J., Lyte M. Epinephrine as a mediator of pulmonary neutrophil sequestration. Shock 2002, 18:46-50.
20. Pace N. Induction of IL-12 gene expression in the brain in septic shock. Biochem Biophys Res Commun 1977, 56:129-132.
21. Regel G., Grotz M., Weltner T., Sturm J., Tscherne H. Pattern of organ failure following severe trauma. World J Surg 1996, 20:422-429.
22. Regel G., Lobenhoffer P., Lehmann U., Pape H.C., Polemann T., Tscherne H. Results of treatment of polytraumatized patients. A comparative analysis of 3406 cases between 1972 and 1991. Unfallchirurg 1993, 96:350-362.
23. Singbartl G. Head injury and disturbed pulmonary function (author's transl). Anaesthesist 1981, 30:431-439.
24. Smith D., Soares H., Pierce J., Perlman K., Saatman D., Meaney D., et al. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathological effects. J Neurotrauma 1995, 12:169-178.
25. Stahel P., Ertel W. Pathophysiologie des Traumas. Unfallchirurgie 2004, Elsevier GmbH, München. A. Rüter, O. Trentz, M. Wagner (Eds.).
26. Van Griensven M., Kuzu M., Breddin M., Bottcher F., Krettek C., Pape H.C., et al. Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma. Exp Toxicol Pathol 2002, 54:203-209.
27. Van Griensven M., Stalp M., Seekamp A. Ischemia-reperfusion directly increases pulmonary endothelial permeability in vitro. Shock 1999, 11:259-263.
28. Wauchob T., Brooks R., Harrison K. Neurogenic pulmonary oedema. Anaesthesia 1984, 39:529-534.
29. Yildrim E., Kaptanoglu E., Ozisik K., Beskonakli E., Okutan O., Sargon M., et al. Ultrastructural changes in pneumocyte type II cells following traumatic brain injury in rats. Eur J Cardiothorac Surg 2004, 25:523-529.
30. Yuan X., Wade C., Prough D., DeWitt D. Traumatic brain injury creates biphasic systemic hemodynamic and organ blood flow responses in rats. J Neurotrauma 1990, 7:141-153.