Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin

Journal of Structural Biology

Volumn 177, Issue 2, 2012, Pages 283-290

  Yokoyama, Takeshi ^a   Mizuguchi, Mineyuki ^b   Nabeshima, Yuko ^b   Kusaka, Katsuhiro ^a   Yamada, Taro ^a   Hosoya, Takaaki ^a   Ohhara, Takashi ^c   Kurihara, Kazuo ^d   Tomoyori, Katsuaki ^a   Tanaka, Ichiro ^a   Niimura, Nobuo ^a  

^a IBARAKI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c NEUTRON SCIENCE AND TECHNOLOGY CENTER   (Japan)

^d JAPAN ATOMIC ENERGY AGENCY   (Japan)

Author keywords

Amyloidosis; Hydrogen bond network; Neutron protein crystallography; Protonation state; Structure stability; Transthyretin

Indexed keywords

DIMER; HISTIDINE; MONOMER; PREALBUMIN; PROLINE; SERINE; TETRAMER; THREONINE; WATER;

ACIDIFICATION; ARTICLE; COMPARATIVE STUDY; CRYSTAL DIFFRACTOMETER; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEVICES; HUMAN; HYDROGEN BOND; MOLECULAR STABILITY; NEUTRON; NEUTRON DIFFRACTION; PH SENSITIVITY; PRIORITY JOURNAL; PROTON TRANSPORT; SENSITIVITY AND SENSIBILITY; X RAY;

AMINO ACID MOTIFS; FOURIER ANALYSIS; HISTIDINE; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; NEUTRON DIFFRACTION; PREALBUMIN; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84857031868     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2011.12.022     Document Type: Article

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