Does pituitary radiotherapy increase the risk of stroke and, if so, what preventative actions should be taken?

Clinical Endocrinology

Volumn 76, Issue 3, 2012, Pages 328-331

  Ayuk, John ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RADIOTHERAPY; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; HUMAN; HYPOPHYSIS ADENOMA; HYPOPITUITARISM; MORBIDITY; MORTALITY; PRIORITY JOURNAL; RADIATION DOSE; REVIEW; RISK FACTOR; STROKE;

ADENOMA; DOSE-RESPONSE RELATIONSHIP, RADIATION; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; PITUITARY NEOPLASMS; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RISK FACTORS; STROKE;

EID: 84857020649     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04300.x     Document Type: Review

References (33)

1. Beclere, J., (1909) The radiotherapeutic treatment of tumours of the hypophysis, gigantism and acromegaly. Archives of the Roentgen Ray, 3, 114.
2. Brada, M., Rajan, B., Traish, D., et al. (1993) The long-term efficacy of conservative surgery and radiotherapy in the control of pituitary adenomas. Clinical Endocrinology, 38, 571-578. (Pubitemid 23168470)
3. Jenkins, P.J., Bates, P., Carson, M.N., et al. (2006) Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism, 91, 1239-1245.
4. Estrada, J., Boronat, M., Mielgo, M., et al. (1997) The long-term outcome of pituitary irradiation after unsuccessful transsphenoidal surgery in Cushing's disease. New England Journal of Medicine, 336, 172-177. (Pubitemid 27034962)
5. Gillam, M.P., Molitch, M.E., Lombardi, G., et al. (2006) Advances in the treatment of prolactinomas. Endocrine Reviews, 27, 485-534. (Pubitemid 44213229)
6. Erfurth, E.M., Bulow, B., Mikoczy, Z., et al. (2001) Is there an increase in second brain tumours after surgery and irradiation for a pituitary tumour? Clinical Endocrinology, 55, 613-616. (Pubitemid 34204444)
7. Sassolas, G., Trouillas, J., Treluyer, C., et al. (1993) Management of nonfunctioning pituitary adenomas. Acta Endocrinologica, 129 (Suppl. 1), 21-26. (Pubitemid 23236057)
8. Noad, R., Narayanan, K.R., Howlett, T., et al. (2004) Evaluation of the effect of radiotherapy for pituitary tumours on cognitive function and quality of life. Clinical Oncology (Royal College of Radiologists), 16, 233-237. (Pubitemid 38696962)
9. Sherlock, M., Ayuk, J., Tomlinson, J.W., et al. (2010) Mortality in patients with pituitary disease. Endocrine Reviews, 31, 301-342.
10. Painter, M.J., Chutorian, A.M., &, Hilal, S.K., (1975) Cerebrovasculopathy following irradiation in childhood. Neurology, 25, 189-194.
11. Bitzer, M., &, Topka, H., (1995) Progressive cerebral occlusive disease after radiation therapy. Stroke, 26, 131-136.
12. Flickinger, J.C., Nelson, P.B., Taylor, F.H., et al. (1989) Incidence of cerebral infarction after radiotherapy for pituitary adenoma. Cancer, 63, 2404-2408. (Pubitemid 19152744)
13. Brada, M., Burchell, L., Ashley, S., et al. (1999) The incidence of cerebrovascular accidents in patients with pituitary adenoma. International Journal of Radiation Oncology, Biology, Physics, 45, 693-698. (Pubitemid 29462651)
14. Erridge, S.C., Conkey, D.S., Stockton, D., et al. (2009) Radiotherapy for pituitary adenomas: long-term efficacy and toxicity. Radiotherapy and Oncology, 93, 597-601.
15. Brada, M., Ashley, S., Ford, D., et al. (2002) Cerebrovascular mortality in patients with pituitary adenoma. Clinical Endocrinology, 57, 713-717. (Pubitemid 36962997)
16. Ayuk, J., Clayton, R.N., Holder, G., et al. (2004) Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism, 89, 1613-1617. (Pubitemid 38507910)
17. Kauppinen-Makelin, R., Sane, T., Reunanen, A., et al. (2005) A nationwide survey of mortality in acromegaly. Journal of Clinical Endocrinology and Metabolism, 90, 4081-4086. (Pubitemid 41058176)
18. Fajardo, L.F., &, Berthrong, M., (1988) Vascular lesions following radiation. Pathology Annual, 23 (Pt 1), 297-330.
19. Fajardo, L.F., (2005) The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncologica, 44, 13-22. (Pubitemid 40249124)
20. Littley, M.D., Shalet, S.M., Beardwell, C.G., et al. (1989) Hypopituitarism following external radiotherapy for pituitary tumours in adults. The Quarterly Journal of Medicine, 70, 145-160. (Pubitemid 19115954)
21. Tsang, R.W., Brierley, J.D., Panzarella, T., et al. (1994) Radiation therapy for pituitary adenoma: treatment outcome and prognostic factors. International Journal of Radiation Oncology, Biology, Physics, 30, 557-565. (Pubitemid 24304466)
22. Rosen, T., &, Bengtsson, B.A., (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, 336, 285-288. (Pubitemid 20229130)
23. Bates, A.S., Van't Hoff, W., Jones, P.J., et al. (1996) The effect of hypopituitarism on life expectancy. Journal of Clinical Endocrinology and Metabolism, 81, 1169-1172. (Pubitemid 26083989)
24. Bulow, B., Hagmar, L., Mikoczy, Z., et al. (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clinical Endocrinology, 46, 75-81. (Pubitemid 27072849)
25. Tomlinson, J.W., Holden, N., Hills, R.K., et al. (2001) Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet, 357, 425-431.
26. Johansson, J.O., Fowelin, J., Landin, K., et al. (1995) Growth hormone-deficient adults are insulin-resistant. Metabolism, 44, 1126-1129. (Pubitemid 26084031)
27. Abdu, T.A., Neary, R., Elhadd, T.A., et al. (2001) Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities. Clinical Endocrinology, 55, 209-216. (Pubitemid 32868585)
28. Rosen, T., Eden, S., Larson, G., et al. (1993) Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinologica, 129, 195-200. (Pubitemid 23295679)
29. Erfurth, E.M., Bulow, B., Svahn-Tapper, G., et al. (2002) Risk factors for cerebrovascular deaths in patients operated and irradiated for pituitary tumors. Journal of Clinical Endocrinology and Metabolism, 87, 4892-4899. (Pubitemid 35316323)
30. Sherlock, M., Reulen, R.C., Alonso, A.A., et al. (2009) ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism, 94, 4216-4223.
31. Plummer, C., Henderson, R.D., O'Sullivan, J.D., et al. (2011) Ischemic stroke and transient ischemic attack after head and neck radiotherapy: a review. Stroke, 42, 2410-2418.
32. Ruben, J.D., Dally, M., Bailey, M., et al. (2006) Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. International Journal of Radiation Oncology, Biology, Physics, 65, 499-508.
33. Abs, R., Feldt-Rasmussen, U., Mattsson, A.F., et al. (2006) Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults-a KIMS database analysis. European Journal of Endocrinology, 155, 79-90. (Pubitemid 44109069)