5-Oxoprolinuria as a cause of high anion gap metabolic acidosis

British Journal of Clinical Pharmacology

Volumn 73, Issue 3, 2012, Pages 489-491

  Verma, Rajanshu ^a   Polsani, Karthik R ^b   Wilt, Jeffrey ^c   Loehrke, Mark E ^b  

^a MAYO CLINIC   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c BORGESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMMONIA; AMYLASE; ASPARTATE AMINOTRANSFERASE; BICARBONATE; CREATININE; PARACETAMOL; PYROGLUTAMIC ACID; TRIACYLGLYCEROL LIPASE;

5 OXOPROLINURIA; ADULT; ANION GAP; BODY MASS; CASE REPORT; DROWSINESS; FEMALE; HEPATORENAL SYNDROME; HIGH ANION GAP METABOLIC ACIDOSIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; LETTER; MALNUTRITION; METABOLIC ACIDOSIS; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; TACHYPNEA; URINARY TRACT DISEASE;

ACETAMINOPHEN; ACID-BASE EQUILIBRIUM; ACIDOSIS; ADULT; AMINO ACID METABOLISM, INBORN ERRORS; BICARBONATES; FEMALE; GLUTATHIONE SYNTHASE; HUMANS; MALNUTRITION; RENAL DIALYSIS;

EID: 84857010070     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2011.04120.x     Document Type: Letter

References (9)

1. Kortmann W, van Agtmael MA, van Diessen J, Kanen BL, Jakobs C, Nanayakkara PW. 5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors. Neth J Med 2008; 66: 354-7.
2. Fenves AZ, Kirkpatrick HM 3rd, Patel VV, Sweetman L, Emmett M. Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen. Clin J Am Soc Nephrol 2006; 1: 441-7.
3. Humphreys BD, Forman JP, Zandi-Nejad K, Bazari H, Seifter J, Magee CC. Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. Am J Kidney Dis 2005; 46: 143-6.
4. Tailor P, Raman T, Garganta CL, Njalsson R, Carlsson K, Ristoff E, Carey HB. Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid). Am J Kidney Dis 2005; 46: e4-10.
5. Brooker G, Jeffery J, Nataraj T, Sair M, Ayling R. High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition. Ann Clin Biochem 2007; 44: 406-9.
6. Tokatli A, Kalkanoǧlu-Sivri HS, Yüce A, Coşkun T. Acetaminophen-induced hepatotoxicity in a glutathione synthetase-deficient patient. Turk J Pediatr 2007; 49: 75-6.
7. Pitt JJ, Hauser S. Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects. Clin Chem 1998; 44: 1497-503.
8. Rolleman EJ, Hoorn EJ, Didden P, Zietse R. Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis. Neth J Med 2008; 66: 351-3.
9. Hodgman MJ, Horn JF, Stork CM, Marraffa JM, Holland MG, Cantor R, Carmel PM. Profound metabolic acidosis and oxoprolinuria in an adult. J Med Toxicol 2007; 3: 119-24.