Dissociation of response variability from firing rate effects in frontal eye field neurons during visual stimulation, working memory, and attention

Journal of Neuroscience

Volumn 32, Issue 6, 2012, Pages 2204-2216

  Chang, Mindy H ^a   Armstrong, Katherine M ^b   Moore, Tirin ^b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; ATTENTION; EVOKED VISUAL RESPONSE; FRONTAL EYE FIELD; MACACA MULATTA; MALE; NERVE CELL; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SINGLE UNIT ACTIVITY; TASK PERFORMANCE; VISUAL STIMULATION; WORKING MEMORY;

ACTION POTENTIALS; ANIMALS; ATTENTION; MACACA MULATTA; MALE; MEMORY, SHORT-TERM; NEURONS; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; REACTION TIME; VISUAL FIELDS; VISUAL PERCEPTION;

EID: 84856999031     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2967-11.2012     Document Type: Article

References (35)

1. Ardid S, Wang XJ, Compte A (2007) An integrated microcircuit model of attentional processing in the neocortex. J Neurosci 27:8486-8495.
2. Armstrong KM, Fitzgerald JK, Moore T (2006) Changes in visual receptive fields with microstimulation of frontal cortex. Neuron 50:791-798.
3. Armstrong KM, Chang MH, Moore T (2009) Selection and maintenance of spatial information by frontal eye field neurons. J Neurosci 29:15621-15629.
4. Brody CD, Romo R, Kepecs A (2003) Basic mechanisms for graded persistent activity: discrete attractors, continuous attractors, and dynamic representations. Curr Opin Neurobiol 13:204-211.
5. Bruce CJ, Goldberg ME (1985) Primate frontal eye fields. I. Single neurons discharging before saccades. J Neurophysiol 53:603-635.
6. Bruce CJ, Goldberg ME, Bushnell MC, Stanton GB (1985) Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. J Neurophysiol 54:714-734.
7. Carandini M, Heeger DJ (1994) Summation and division by neurons in primate visual cortex. Science 264:1333-1336.
8. Churchland AK, Kiani R, Chaudhuri R, Wang XJ, Pouget A, Shadlen MN (2011) Variance as a signature of neural computations during decision making. Neuron 69:818-831.
9. Churchland MM, Yu BM, Ryu SI, Santhanam G, Shenoy KV (2006) Neural variability in premotor cortex provides a signature of motor preparation. J Neurosci 26:3697-3712.
10. Churchland MM, Yu BM, Sahani M, Shenoy KV (2007) Techniques for extracting single-trial activity patterns from large-scale neural recordings. Curr Opin Neurobiol 17:609-618.
11. ChurchlandMM, Yu BM, Cunningham JP, Sugrue LP, Cohen MR, Corrado GS, Newsome WT, Clark AM, Hosseini P, Scott BB, Bradley DC, Smith MA, Kohn A, Movshon JA, Armstrong KM, Moore T, Chang SW, Snyder LH, Lisberger SG, Priebe NJ, et al. (2010) Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat Neurosci 13:369-378.
12. Cohen MR, Maunsell JH (2009) Attention improves performance primarily by reducing interneuronal correlations. Nat Neurosci 12:1594-1600.
13. Constantinidis C, Goldman-Rakic PS (2002) Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex. J Neurophysiol 88:3487-3497.
14. Efron B (1979) Bootstrap methods: another look at the jackknife. Ann Stat 7:1-26.
15. Elstrott J, Anishchenko A, Greschner M, Sher A, Litke AM, Chichilnisky EJ, Feller MB (2008) Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves. Neuron 58:499-506.
16. Finn IM, Priebe NJ, Ferster D (2007) The emergence of contrast-invariant orientation tuning in simple cells of cat visual cortex. Neuron 54:137-152.
17. Goldman MS (2009) Memory without feedback in a neural network. Neuron 61:621-634.
18. Hussar C, Pasternak T (2010) Trial-to-trial variability of the prefrontal neurons reveals the nature of their engagement in a motion discrimination task. Proc Natl Acad Sci U S A 107:21842-21847.
19. Major G, Tank D (2004) Persistent neural activity: prevalence and mechanisms. Curr Opin Neurobiol 14:675-684.
20. Miller P, Wang XJ (2006) Power-law neuronal fluctuations in a recurrent network model of parametric working memory. J Neurophysiol 95:1099-1114.
21. Mitchell JF, Sundberg KA, Reynolds JH (2007) Differential attentiondependent response modulation across cell classes in macaque visual area V4. Neuron 55:131-141.
22. Mitchell JF, Sundberg KA, Reynolds JH (2009) Spatial attention decorrelates intrinsic activity fluctuations in macaque area V4. Neuron 63:879-888.
23. Mitchell SJ, Silver RA (2003) Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38:433-445.
24. Monier C, Chavane F, Baudot P, Graham LJ, Frégnac Y (2003) Orientation and direction selectivity of synaptic inputs in visual cortical neurons: a diversity of combinations produces spike tuning. Neuron 37:663-680.
25. Moore T, FallahM (2001) Control of eye movements and spatial attention. Proc Natl Acad Sci U S A 98:1273-1276.
26. Noudoost B, Chang MH, Steinmetz NA, Moore T (2010) Top-down control of visual attention. Curr Opin Neurobiol 20:183-190.
27. OramMW (2011) Visual stimulation decorrelates neuronal activity. J Neurophysiol 105:942-957.
28. Rajan K, Abbott LF, Sompolinsky H (2010) Stimulus-dependent suppression of chaos in recurrent neural networks. Phys Rev E 82:011903+.
29. Reynolds JH, Heeger DJ (2009) The normalization model of attention. Neuron 61:168-185.
30. Shu Y, Hasenstaub A, McCormick DA (2003) Turning on and off recurrent balanced cortical activity. Nature 423:288-293.
31. Sommer MA, Wurtz RH (2000) Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. J Neurophysiol 83:1979-2001.
32. Steinmetz NA, Moore T (2010) Changes in the response rate and response variability of area V4 neurons during the preparation of saccadic eye movements. J Neurophysiol 103:1171-1178.
33. Wang XJ (2001) Synaptic reverberation underlying mnemonic persistent activity. Trends Neurosci 24:455-463.
34. Wang XJ (2008) Decision making in recurrent neuronal circuits. Neuron 60:215-234.
35. White JM, Sparks DL, Stanford TR (1994) Saccades to remembered target locations: an analysis of systematic and variable errors. Vision Res 34:79-92.