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Volumn 71, Issue 3, 2012, Pages 221-226

An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis

Author keywords

Arzoxifene; Bazedoxifene; Lasofoxifene; Ospemifene; Osteoporosis; SERM

Indexed keywords

ACOLBIFENE; ARZOXIFENE; BAZEDOXIFENE; CONJUGATED ESTROGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LASOFOXIFENE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LSN 2120310; OSPEMIFENE; PLACEBO; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

EID: 84856961694     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2011.11.018     Document Type: Review
Times cited : (46)

References (43)
  • 1
    • 0034526468 scopus 로고    scopus 로고
    • Epidemiology of osteoporotic fractures
    • E. Dennison, and C. Cooper Epidemiology of osteoporotic fractures Horm Res 54 2000 58 63 (Pubitemid 32037589)
    • (2000) Hormone Research , vol.54 , Issue.SUPPL. 1 , pp. 58-63
    • Dennison, E.1    Cooper, C.2
  • 3
    • 33750209491 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    • DOI 10.1007/s00198-006-0172-4
    • O. Johnell, and J.A. Kanis An estimate of the worldwide prevalence and disability associated with osteoporotic fractures Osteoporos Int 17 2006 1726 1733 (Pubitemid 44607392)
    • (2006) Osteoporosis International , vol.17 , Issue.12 , pp. 1726-1733
    • Johnell, O.1    Kanis, J.A.2
  • 5
    • 15044344862 scopus 로고    scopus 로고
    • Requirements for DXA for the management of osteoporosis in Europe
    • DOI 10.1007/s00198-004-1811-2
    • J.A. Kanis, and O. Johnell Requirements for DXA for the management of osteoporosis in Europe Osteoporos Int 16 2005 229 238 (Pubitemid 40379422)
    • (2005) Osteoporosis International , vol.16 , Issue.3 , pp. 229-238
    • Kanis, J.A.1    Johnell, O.2
  • 6
    • 0037434618 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators - Mechanisms of action and application to clinical practice
    • DOI 10.1056/NEJMra022219
    • B.L. Riggs, and L.C. Hartmann Selective estrogen-receptor modulators - mechanisms of action and application to clinical practice N Engl J Med 348 2003 618 629 (Pubitemid 36210865)
    • (2003) New England Journal of Medicine , vol.348 , Issue.7 , pp. 618-629
    • Riggs, B.L.1    Hartmann, L.C.2
  • 7
    • 67649574704 scopus 로고    scopus 로고
    • Designing the ideal selective estrogen receptor modulator - An achievable goal?
    • H.S. Taylor Designing the ideal selective estrogen receptor modulator - an achievable goal? Menopause 16 2009 609 615
    • (2009) Menopause , vol.16 , pp. 609-615
    • Taylor, H.S.1
  • 9
    • 56549092475 scopus 로고    scopus 로고
    • Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: Results from a 3-year, randomized, placebo-, and active-controlled clinical trial
    • S.L. Silverman, C. Christiansen, and H.K. Genant Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: results from a 3-year, randomized, placebo-, and active-controlled clinical trial J Bone Miner Res 23 2008 1923 1934
    • (2008) J Bone Miner Res , vol.23 , pp. 1923-1934
    • Silverman, S.L.1    Christiansen, C.2    Genant, H.K.3
  • 10
    • 43049175471 scopus 로고    scopus 로고
    • FRAX and the assessment of fracture probability in men and women from the UK
    • J.A. Kanis, O. Johnell, A. Oden, H. Johansson, and E. McCloskey FRAX and the assessment of fracture probability in men and women from the UK Osteoporos Int 19 2008 385 397
    • (2008) Osteoporos Int , vol.19 , pp. 385-397
    • Kanis, J.A.1    Johnell, O.2    Oden, A.3    Johansson, H.4    McCloskey, E.5
  • 11
    • 67349207750 scopus 로고    scopus 로고
    • Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX
    • J.A. Kanis, H. Johansson, A. Oden, and E.V. McCloskey Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX Bone 44 2009 1049 1054
    • (2009) Bone , vol.44 , pp. 1049-1054
    • Kanis, J.A.1    Johansson, H.2    Oden, A.3    McCloskey, E.V.4
  • 12
    • 77951817107 scopus 로고    scopus 로고
    • Assessment of the effect of bazedoxifene on non-vertebral fracture risk
    • Available at: [accessed 18.10.10]
    • E. McCloskey, H. Johansson, A. Oden, A. Chines, and J. Kanis Assessment of the effect of bazedoxifene on non-vertebral fracture risk J Bone Miner Res 24 Suppl. 1 2009 Available at: http://www.asbmr.org/Meetings/AnnualMeeting/ AbstractDetail.aspx?aid=6c55b263-692e-4a37-b807-f7a153641564 [accessed 18.10.10]
    • (2009) J Bone Miner Res , vol.24 , Issue.SUPPL. 1
    • McCloskey, E.1    Johansson, H.2    Oden, A.3    Chines, A.4    Kanis, J.5
  • 13
    • 77954885674 scopus 로고    scopus 로고
    • Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled phase 3 study of postmenopausal women with osteoporosis
    • C. Christiansen, C.H. Chesnut III, and J.D. Adachi Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled phase 3 study of postmenopausal women with osteoporosis BMC Musculoskelet Disord 11 2010 130
    • (2010) BMC Musculoskelet Disord , vol.11 , pp. 130
    • Christiansen, C.1    Chesnut Iii, C.H.2    Adachi, J.D.3
  • 14
    • 70350438889 scopus 로고    scopus 로고
    • Bazedoxifene effects on the reproductive tract in postmenopausal women at risk for osteoporosis
    • J.V. Pinkerton, D.F. Archer, and W.H. Utian Bazedoxifene effects on the reproductive tract in postmenopausal women at risk for osteoporosis Menopause 16 2009 1102 1108
    • (2009) Menopause , vol.16 , pp. 1102-1108
    • Pinkerton, J.V.1    Archer, D.F.2    Utian, W.H.3
  • 15
    • 70350443878 scopus 로고    scopus 로고
    • Bazedoxifene, a selective estrogen receptor modulator: Effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women
    • D.F. Archer, J.V. Pinkerton, and W.H. Utian Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women Menopause 16 2009 1109 1115
    • (2009) Menopause , vol.16 , pp. 1109-1115
    • Archer, D.F.1    Pinkerton, J.V.2    Utian, W.H.3
  • 16
    • 71249138285 scopus 로고    scopus 로고
    • The effects of bazedoxifene on mammographic breast density in postmenopausal women with osteoporosis
    • J.A. Harvey, M.K. Holm, R. Ranganath, P.A. Guse, E.A. Trott, and E. Helzner The effects of bazedoxifene on mammographic breast density in postmenopausal women with osteoporosis Menopause 16 2009 1193 1196
    • (2009) Menopause , vol.16 , pp. 1193-1196
    • Harvey, J.A.1    Holm, M.K.2    Ranganath, R.3    Guse, P.A.4    Trott, E.A.5    Helzner, E.6
  • 17
    • 78651506084 scopus 로고    scopus 로고
    • Safety and tolerability of bazedoxifene in postmenopausal women with osteoporosis: Results of a 5-year, randomized, placebo-controlled phase 3 trial
    • T.J. de Villiers, A.A. Chines, and S. Palacios Safety and tolerability of bazedoxifene in postmenopausal women with osteoporosis: results of a 5-year, randomized, placebo-controlled phase 3 trial Osteoporos Int 22 2011 567 576
    • (2011) Osteoporos Int , vol.22 , pp. 567-576
    • De Villiers, T.J.1    Chines, A.A.2    Palacios, S.3
  • 18
    • 84857361055 scopus 로고    scopus 로고
    • Sustained efficacy and safety of bazedoxifene in preventing fractures in postmenopausal women with osteoporosis: Results of a 5-year, randomized, placebo-controlled study
    • [Epub ahead of print]
    • S.L. Silverman, A.A. Chines, and D.L. Kendler Sustained efficacy and safety of bazedoxifene in preventing fractures in postmenopausal women with osteoporosis: results of a 5-year, randomized, placebo-controlled study Osteoporos Int 2011 [Epub ahead of print]
    • (2011) Osteoporos Int
    • Silverman, S.L.1    Chines, A.A.2    Kendler, D.L.3
  • 19
    • 84881158492 scopus 로고    scopus 로고
    • Long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: Results of a 7-year, randomized, placebo-controlled study
    • June 8-11, 2011, Rome, Italy
    • S. Palacios, S. Silverman, and A.B. Levine Long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: results of a 7-year, randomized, placebo-controlled study Presented at the 13th International Menopause Society World Congress on Menopause June 8-11, 2011, Rome, Italy 2011
    • (2011) Presented at the 13th International Menopause Society World Congress on Menopause
    • Palacios, S.1    Silverman, S.2    Levine, A.B.3
  • 20
    • 84856947891 scopus 로고    scopus 로고
    • Reproductive safety of bazedoxifene in postmenopausal women with osteoporosis: Results of a 7-year, randomized, placebo-controlled, phase 3 study
    • Abstract S-7
    • S. Palacios, T.J. de Villiers, and F. De Cicco-Nardone Reproductive safety of bazedoxifene in postmenopausal women with osteoporosis: results of a 7-year, randomized, placebo-controlled, phase 3 study Menopause 18 2011 1344 Abstract S-7
    • (2011) Menopause , vol.18 , pp. 1344
    • Palacios, S.1    De Villiers, T.J.2    De Cicco-Nardone, F.3
  • 21
    • 78049468658 scopus 로고    scopus 로고
    • Tissue-selective agents: Selective estrogen receptor modulators and the tissue-selective estrogen complex
    • J.H. Pickar, and S. Mirkin Tissue-selective agents: selective estrogen receptor modulators and the tissue-selective estrogen complex Menopause Int 16 2010 121 128
    • (2010) Menopause Int , vol.16 , pp. 121-128
    • Pickar, J.H.1    Mirkin, S.2
  • 22
    • 69049083661 scopus 로고    scopus 로고
    • Efficacy of tissue-selective estrogen complex of bazedoxifene/conjugated estrogens for osteoporosis prevention in at-risk postmenopausal women
    • R. Lindsay, J.C. Gallagher, R. Kagan, J.H. Pickar, and G. Constantine Efficacy of tissue-selective estrogen complex of bazedoxifene/conjugated estrogens for osteoporosis prevention in at-risk postmenopausal women Fertil Steril 92 2009 1045 1052
    • (2009) Fertil Steril , vol.92 , pp. 1045-1052
    • Lindsay, R.1    Gallagher, J.C.2    Kagan, R.3    Pickar, J.H.4    Constantine, G.5
  • 23
    • 69049120132 scopus 로고    scopus 로고
    • Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile
    • R.A. Lobo, J.V. Pinkerton, and M.L. Gass Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile Fertil Steril 92 2009 1025 1038
    • (2009) Fertil Steril , vol.92 , pp. 1025-1038
    • Lobo, R.A.1    Pinkerton, J.V.2    Gass, M.L.3
  • 24
    • 69049085452 scopus 로고    scopus 로고
    • Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy
    • J.H. Pickar, I.-T. Yeh, G. Bachmann, and L. Speroff Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy Fertil Steril 92 2009 1018 1024
    • (2009) Fertil Steril , vol.92 , pp. 1018-1024
    • Pickar, J.H.1    Yeh, I.-T.2    Bachmann, G.3    Speroff, L.4
  • 25
    • 69049112720 scopus 로고    scopus 로고
    • Bazedoxifene/conjugated estrogens (BZA/CE): Incidence of uterine bleeding in postmenopausal women
    • D.F. Archer, V. Lewis, B.R. Carr, S. Olivier, and J.H. Pickar Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women Fertil Steril 92 2009 1039 1044
    • (2009) Fertil Steril , vol.92 , pp. 1039-1044
    • Archer, D.F.1    Lewis, V.2    Carr, B.R.3    Olivier, S.4    Pickar, J.H.5
  • 26
    • 33745253921 scopus 로고    scopus 로고
    • Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene
    • M.R. McClung, E. Siris, and S. Cummings Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene Menopause 13 2006 377 386
    • (2006) Menopause , vol.13 , pp. 377-386
    • McClung, M.R.1    Siris, E.2    Cummings, S.3
  • 27
    • 33748189110 scopus 로고    scopus 로고
    • Lasofoxifene increased BMD of the spine and hip and decreased bone turnover markers in postmenopausal women with low or normal BMD
    • M. McClung, E. Siris, and S. Cummings Lasofoxifene increased BMD of the spine and hip and decreased bone turnover markers in postmenopausal women with low or normal BMD J Bone Miner Res 20 2005 S97
    • (2005) J Bone Miner Res , vol.20 , pp. 97
    • McClung, M.1    Siris, E.2    Cummings, S.3
  • 28
    • 33645361883 scopus 로고    scopus 로고
    • Extraskeletal effects of lasofoxifene on postmenopausal women
    • M. Davidson, A. Moffett, and F. Welty Extraskeletal effects of lasofoxifene on postmenopausal women J Bone Miner Res 20 2005 S173
    • (2005) J Bone Miner Res , vol.20 , pp. 173
    • Davidson, M.1    Moffett, A.2    Welty, F.3
  • 29
    • 77349090257 scopus 로고    scopus 로고
    • Lasofoxifene in postmenopausal women with osteoporosis
    • S.R. Cummings, K. Ensrud, and P.D. Delmas Lasofoxifene in postmenopausal women with osteoporosis N Engl J Med 362 2010 686 696
    • (2010) N Engl J Med , vol.362 , pp. 686-696
    • Cummings, S.R.1    Ensrud, K.2    Delmas, P.D.3
  • 31
    • 78651407344 scopus 로고    scopus 로고
    • Postmenopausal evaluation and risk reduction with lasofoxifene trial: 5-year gynecological outcomes
    • S.R. Goldstein, P. Neven, and S. Cummings Postmenopausal evaluation and risk reduction with lasofoxifene trial: 5-year gynecological outcomes Menopause 18 2010 17 22
    • (2010) Menopause , vol.18 , pp. 17-22
    • Goldstein, S.R.1    Neven, P.2    Cummings, S.3
  • 32
    • 79954480772 scopus 로고    scopus 로고
    • Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass
    • R.W. Downs Jr., A.M. Moffett, A. Ghosh, D.A. Cox, S.A. Dowsett, and K. Harper Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass Osteoporos Int 21 2009 1215 1226
    • (2009) Osteoporos Int , vol.21 , pp. 1215-1226
    • Downs Jr., R.W.1    Moffett, A.M.2    Ghosh, A.3    Cox, D.A.4    Dowsett, S.A.5    Harper, K.6
  • 33
    • 67650266737 scopus 로고    scopus 로고
    • Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass
    • M. Bolognese, J.H. Krege, and W.H. Utian Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass J Clin Endocrinol Metab 94 2009 2284 2289
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2284-2289
    • Bolognese, M.1    Krege, J.H.2    Utian, W.H.3
  • 34
    • 80052466472 scopus 로고    scopus 로고
    • Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women
    • [Epub ahead of print]
    • S.R. Cummings, M. McClung, and J.Y. Reginster Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women J Bone Miner Res 2010 [Epub ahead of print]
    • (2010) J Bone Miner Res
    • Cummings, S.R.1    McClung, M.2    Reginster, J.Y.3
  • 35
    • 77952270259 scopus 로고    scopus 로고
    • Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: Results from a pivotal phase 3 study
    • G.A. Bachmann, and J.O. Komi Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study Menopause 17 2010 480 486
    • (2010) Menopause , vol.17 , pp. 480-486
    • Bachmann, G.A.1    Komi, J.O.2
  • 36
    • 1542267719 scopus 로고    scopus 로고
    • Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women
    • DOI 10.1080/09513590410001672197
    • J. Komi, J. Heikkinen, E.M. Rutanen, K. Halonen, R. Lammintausta, and O. Ylikorkala Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women Gynecol Endocrinol 18 2004 152 158 (Pubitemid 38328094)
    • (2004) Gynecological Endocrinology , vol.18 , Issue.3 , pp. 152-158
    • Komi, J.1    Heikkinen, J.2    Rutanen, E.-M.3    Halonen, K.4    Lammintausta, R.5    Ylikorkala, O.6
  • 38
    • 0642367765 scopus 로고    scopus 로고
    • Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: A double-blind, randomized trial
    • E.M. Rutanen, J. Heikkinen, K. Halonen, J. Komi, R. Lammintausta, and O. Ylikorkala Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial Menopause 10 2003 433 439
    • (2003) Menopause , vol.10 , pp. 433-439
    • Rutanen, E.M.1    Heikkinen, J.2    Halonen, K.3    Komi, J.4    Lammintausta, R.5    Ylikorkala, O.6
  • 42
    • 8444249745 scopus 로고    scopus 로고
    • The selective estrogen receptor modulator SCH 57068 prevents bone loss, reduces serum cholesterol and blocks estrogen-induced uterine hypertrophy in ovariectomized rats
    • DOI 10.1016/j.jsbmb.2004.05.009, PII S0960076004003280
    • P.E. Goss, S. Qi, A.M. Cheung, H. Hu, M. Mendes, and K.P. Pritzker The selective estrogen receptor modulator SCH 57068 prevents bone loss, reduces serum cholesterol and blocks estrogen-induced uterine hypertrophy in ovariectomized rats J Steroid Biochem Mol Biol 92 2004 79 87 (Pubitemid 39486065)
    • (2004) Journal of Steroid Biochemistry and Molecular Biology , vol.92 , Issue.1-2 , pp. 79-87
    • Goss, P.E.1    Qi, S.2    Cheung, A.M.3    Hu, H.4    Mendes, M.5    Pritzker, K.P.H.6


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