Cerebellar theta burst stimulation impairs eyeblink classical conditioning

Journal of Physiology

Volumn 590, Issue 4, 2012, Pages 887-897

  Hoffland, Britt S ^a,b   Bologna, Matteo ^a,c   Kassavetis, Panagiotis ^a   Teo, James T H ^a   Rothwell, John C ^a   Yeo, Christopher H ^d   van de Warrenburg, Bart P ^b   Edwards, Mark J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b RADBOUD UNIVERSITY   (Netherlands)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN FUNCTION; CEREBELLUM CORTEX; CONTINUOUS THETA BURST STIMULATION; CONTROLLED STUDY; ELECTROSTIMULATION; EVOKED CORTICAL RESPONSE; EVOKED MUSCLE RESPONSE; EXPERIMENTAL STUDY; EYEBLINK CLASSICAL CONDITIONING; EYELID REFLEX; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR PERFORMANCE; NEUROMUSCULAR FUNCTION; NON INVASIVE PROCEDURE; NORMAL HUMAN; PRIORITY JOURNAL; RIGHT HEMISPHERE; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; BLINKING; CEREBELLUM; CONDITIONING, CLASSICAL; FEMALE; HUMANS; MALE; TRANSCRANIAL MAGNETIC STIMULATION; YOUNG ADULT;

EID: 84856940536     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.218537     Document Type: Article

References (34)

1. Barker AT (2002). The history and basic principles of magnetic nerve stimulation. In Handbook of Transcranial Magnetic Stimulation, eds Pascual-Leone A, Davey NJ, Rothwell JC, Wasserman EM & Puri BK, pp. 3-17. Oxford UP, London
2. Boyden ES, Katoh A, Pyle JL, Chatila TA, Tsien RW & Raymond JL (2006). Selective engagement of plasticity mechanisms for motor memory storage. Neuron 51, 823-834.
3. Brickley SG, Revilla V, Cull-Candy SG, Wisden W & Farrant M (2001). Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409, 88-92.
4. Christian KM & Thompson RF (2003). Neural substrates of eyeblink conditioning: acquisition and retention. Learn Mem 10, 427-455.
5. De Zeeuw CI & Yeo CH (2005). Time and tide in cerebellar memory formation. Curr Opin Neurobiol 15, 667-674.
6. Del Olmo MF, Cheeran B, Koch G & Rothwell JC (2007). Role of the cerebellum in externally paced rhythmic finger movements. J Neurophysiol 98, 145-152.
7. Fierro B, Palermo A, Puma A, Francolini M, Panetta ML, Daniele O & Brighina F (2007). Role of the cerebellum in time perception: a TMS study in normal subjects. J Neurol Sci 263, 107-112.
8. Gerwig M, Dimitrova A, Kolb FP, Maschke M, Brol B, Kunnel A, Boring D, Thilmann AF, Forsting M, Diener HC & Timmann D (2003). Comparison of eyeblink conditioning in patients with superior and posterior inferior cerebellar lesions. Brain 126, 71-94.
9. Gerwig M, Guberina H, Esser AC, Siebler M, Schoch B, Frings M, Kolb FP, Aurich V, Beck A, Forsting M & Timmann D (2010). Evaluation of multiple-session delay eyeblink conditioning comparing patients with focal cerebellar lesions and cerebellar degeneration. Behav Brain Res 212, 143-151.
10. Gerwig M, Hajjar K, Dimitrova A, Maschke M, Kolb FP, Frings M, Thilmann AF, Forsting M, Diener HC & Timmann D (2005). Timing of conditioned eyeblink responses is impaired in cerebellar patients. J Neurosci 25, 3919-3931.
11. Hansel C, de JM, Belmeguenai A, Houtman SH, Buitendijk GH, Andreev D, De Zeeuw CI & Elgersma Y (2006). αCaMKII is essential for cerebellar LTD and motor learning. Neuron 51, 835-843.
12. Harvey JA, Welsh JP, Yeo CH & Romano AG (1993). Recoverable and nonrecoverable deficits in conditioned responses after cerebellar cortical lesions. J Neurosci 13, 1624-1635.
13. Hess G, Aizenman CD & Donoghue JP (1996). Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex. J Neurophysiol 75, 1765-1778.
14. Huang YZ, Edwards MJ, Rounis E, Bhatia KP & Rothwell JC (2005). Theta burst stimulation of the human motor cortex. Neuron 45, 201-206.
15. Kellett DO, Fukunaga I, Chen-Kubota E, Dean P & Yeo CH (2010). Memory consolidation in the cerebellar cortex. PLoS One 5, e11737.
16. Kimura J, Wilkinson JT, Damasio H, Adams HR Jr, Shivapour E & Yamada T (1985). Blink reflex in patients with hemispheric cerebrovascular accident (CVA). Blink reflex in CVA. J Neurol Sci 67, 15-28.
17. Koch G, Mori F, Marconi B, Codeca C, Pecchioli C, Salerno S, Torriero S, Lo GE, Mir P, Oliveri M & Caltagirone C (2008). Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum. Clin Neurophysiol 119, 2559-2569.
18. Koekkoek SK, Hulscher HC, Dortland BR, Hensbroek RA, Elgersma Y, Ruigrok TJ & De Zeeuw CI (2003). Cerebellar LTD and learning-dependent timing of conditioned eyelid responses. Science 301, 1736-1739.
19. Linden DJ (2003). Neuroscience. From molecules to memory in the cerebellum. Science 301, 1682-1685.
20. Lye RH, Oboyle DJ, Ramsden RT & Schady W (1988). Effects of a unilateral cerebellar lesion on the acquisition of eye-blink conditioning in man. J Physiol 403, 58.
21. Miall RC & Christensen LO (2004). The effect of rTMS over the cerebellum in normal human volunteers on peg-board movement performance. Neurosci Lett 371, 185-189.
22. Ohyama T, Nores WL, Medina JF, Riusech FA & Mauk MD (2006). Learning-induced plasticity in deep cerebellar nucleus. J Neurosci 26, 12656-12663.
23. Perrett SP, Ruiz BP & Mauk MD (1993). Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J Neurosci 13, 1708-1718.
24. Popa T, Russo M & Meunier S (2010). Long-lasting inhibition of cerebellar output. Brain Stimul 3, 161-169.
25. Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, Dimitrijevic MR, Hallett M, Katayama Y & Lucking CH (1994). Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 91, 79-92.
26. Schonewille M, Gao Z, Boele HJ, Veloz MF, Amerika WE, Simek AA, De Jeu MT, Steinberg JP, Takamiya K, Hoebeek FE, Linden DJ, Huganir RL & De Zeeuw CI (2011). Reevaluating the role of LTD in cerebellar motor learning. Neuron 70, 43-50.
27. Solomon PR, Stowe GT & Pendlbeury WW (1989). Disrupted eyelid conditioning in a patient with damage to cerebellar afferents. Behav Neurosci 103, 898-902.
28. Stefan K, Gentner R, Zeller D, Dang S & Classen J (2008). Theta-burst stimulation: remote physiological and local behavioral after-effects. Neuroimage 40, 265-274.
29. Thompson RF & Steinmetz JE (2009). The role of the cerebellum in classical conditioning of discrete behavioral responses. Neuroscience 162, 732-755.
30. Timmann D, Baier C, Dlener HC & Kolb FP (1998). Impaired acquisition of limb flexion reflex and eyeblink classical conditioning in a cerebellar patient. Neurocase: The Neural Basis of Cognition4, 207-217.
31. Timmann D, Gerwig M, Frings M, Maschke M & Kolb FP (2005). Eyeblink conditioning in patients with hereditary ataxia: a one-year follow-up study. Exp Brain Res 162, 332-345.
32. Torriero S, Oliveri M, Koch G, Caltagirone C & Petrosini L (2004). Interference of left and right cerebellar rTMS with procedural learning. J Cogn Neurosci 16, 1605-1611.
33. Woodruff-Pak DS, Papka M & Ivry RB (1996). Cerebellar involvement in eyeblink classical conditioning in humans. Neuropsychology 10, 443-458.
34. Yeo CH & Hesslow G (1998). Cerebellum and conditioned reflexes. Trends Cogn Sci 2, 322-330.