The natural cell-penetrating peptide crotamine targets tumor tissue in vivo and triggers a lethal calcium-dependent pathway in cultured cells

Molecular Pharmaceutics

Volumn 9, Issue 2, 2012, Pages 211-221

  Nascimento, Fabio D ^a   Sancey, Lucie ^b,c   Pereira, Alexandre ^d   Rome, Claire ^b,c   Oliveira, Vitor ^e   Oliveira, Eduardo B ^f   Nader, Helena B ^e   Yamane, Tetsuo ^g   Kerkis, Irina ^d   Tersariol, Ivarne L S ^h   Coll, Jean Luc ^b,c   Hayashi, Mirian A F ^e  

^a Universidade Bandeirante de Sao Paulo   (Brazil)

^b INSTITUT ALBERT BONNIOT   (France)

^c UNIV GRENOBLE ALPES   (France)

^d INSTITUTO BUTANTAN   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g Centro de Biotecnologia da Amazonia CBA   (Brazil)

^h UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

Author keywords

actively proliferating cells; cellular uptake; intracellular calcium; mitochondria; tumor specific cell penetrating peptides

Indexed keywords

CALCIUM; CROTAMINE; THAPSIGARGIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ORGANELLE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; DRUG UPTAKE; EMBRYO; ENDOPLASMIC RETICULUM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LYSOSOME; MEMBRANE POTENTIAL; MICROFLUOROMETRY; MITOCHONDRION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM; CALCIUM SIGNALING; CELL DEATH; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; CHO CELLS; CRICETINAE; CRICETULUS; CROTALID VENOMS; CROTALUS; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; INJECTIONS, INTRAPERITONEAL; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; NEOPLASMS; THAPSIGARGIN; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84856933588     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2000605     Document Type: Article

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