Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series

Bipolar Disorders

Volumn 14, Issue 1, 2012, Pages 71-79

  Greenwood, Tiffany A ^a,b   Nievergelt, Caroline M ^a   Sadovnick, A Dessa ^c   Remick, Ronald A ^d   Keck, Paul E ^e,f   Mcelroy, Susan L ^e,f   Shekhtman, Tatyana ^a,b   Mckinney, Rebecca ^a,b   Kelsoe, John R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d ST PAUL S HOSPITAL   (Canada)

^e LINDNER CENTER OF HOPE   (United States)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Genetics; Genome wide; Linkage; Mood disorder

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CHROMOSOME 22Q; CHROMOSOME 6; CHROMOSOME 6Q; CHROMOSOME 7; CHROMOSOME MARKER; FAMILY; FEMALE; FLUORESCENCE; GENE REPLICATION; GENETIC LINKAGE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PEDIGREE; PRIORITY JOURNAL; PROMOTER REGION; RECURRENT DISEASE; SCORING SYSTEM;

BIPOLAR DISORDER; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 6; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC LINKAGE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LOD SCORE; MALE; PEDIGREE;

EID: 84856901245     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2011.00970.x     Document Type: Article

References (34)

1. Goodwin FK, Jameson KR. Manic-Depressive Illness. New York: Oxford University Press, 1990.
2. Taylor L, Faraone SV, Tsuang MT. Family, twin, and adoption studies of bipolar disease. Curr Psychiatry Rep 2002; 4: 130-133.
3. Craddock N, Jones I. Genetics of bipolar disorder. J Med Genet 1999; 36: 585-594.
4. Tsuang MT, Faraone SV. The Genetics of Mood Disorders. Baltimore: Johns Hopkins University Press, 1990.
5. Spence MA, Flodman PL, Sadovnick AD, Bailey-Wilson JE, Ameli H, Remick RA. Bipolar disorder: evidence for a major locus. Am J Med Genet 1995; 60: 370-376.
6. Rice J, Reich T, Andreasen NC et al. The familial transmission of bipolar illness. Arch Gen Psychiatry 1987; 44: 441-447.
7. Nurnberger JI Jr, Foroud T. Genetics of bipolar affective disorder. Curr Psychiatry Rep 2000; 2: 147-157.
8. Kelsoe JR, Sadovnick AD, Kristbjarnarson H et al. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet 1996; 67: 533-540.
9. Lachman HM, Kelsoe JR, Remick RA et al. Linkage studies suggest a possible locus for bipolar disorder near the velo-cardio-facial syndrome region on chromosome 22. Am J Med Genet 1997; 74: 121-128.
10. Kelsoe JR, Spence MA, Loetscher E et al. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 2001; 98: 585-590.
11. Shaw SH, Mroczkowski-Parker Z, Shekhtman T et al. Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series. Mol Psychiatry 2003; 8: 558-564.
12. Endicott J, Spitzer RL. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978; 35: 837-844.
13. Murray JC, Buetow KH, Weber JL et al. A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC). Science 1994; 265: 2049-2054.
14. Dib C, Faure S, Fizames C et al. A comprehensive genetic map of the human genome based on 5, 264 microsatellites. Nature 1996; 380: 152-154.
15. Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS. 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 1991; 19: 4008.
16. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
17. Kong X, Murphy K, Raj T, He C, White PS, Matise TC. A combined linkage-physical map of the human genome. Am J Hum Genet 2004; 75: 1143-1148.
18. Nievergelt CM, Smith DW, Kohlenberg JB, Schork NJ. Large-scale integration of human genetic and physical maps. Genome Res 2004; 14: 1199-1205.
19. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997; 61: 1179-1188.
20. Lathrop GM, Lalouel JM, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984; 81: 3443-3446.
21. Patel SD, Le-Niculescu H, Koller DL et al. Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 850-877.
22. Ferreira MA, O'Donovan MC, Meng YA et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008; 40: 1056-1058.
23. McInnis MG, Dick DM, Willour VL et al. Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biol Psychiatry 2003; 54: 1265-1273.
24. Cheng R, Juo SH, Loth JE et al. Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry 2006; 11: 252-260.
25. Lindholm E, Ekholm B, Shaw S et al. A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet 2001; 69: 96-105.
26. Philippe A, Martinez M, Guilloud-Bataille M et al. Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study. Hum Mol Genet 1999; 8: 805-812.
27. Sukumar S, Wang S, Hoang K et al. Subtle overlapping deletions in the terminal region of chromosome 6q24.2-q26: three cases studied using FISH. Am J Med Genet 1999; 87: 17-22.
28. Dick DM, Foroud T, Flury L et al. Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the national institute of mental health genetics initiative. Am J Hum Genet 2003; 73: 107-114.
29. Park N, Juo SH, Cheng R et al. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 2004; 9: 1091-1099.
30. Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7: 405-411.
31. Berrettini WH, Ferraro TN, Goldin LR et al. Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 1994; 91: 5918-5921.
32. Barrett TB, Hauger RL, Kennedy JL et al. Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Mol Psychiatry 2003; 8: 546-557.
33. Zhou X, Tang W, Greenwood TA et al. Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS ONE 2009; 4: e5196.
34. Suarez BK, Hampe CL, Van Eerdewegh P. Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR eds. Genetic Approaches to Mental Disorders. Washington, DC: American Psychiatric Press, 1994: 23-46.