Alendronate affects osteoblast functions by crosstalk through ephrinB1-EphB

Journal of Dental Research

Volumn 91, Issue 3, 2012, Pages 268-274

  Shimizu, E ^a,b   Tamasi, J ^c   Partridge, N C ^a  

^a NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^b Department of Endodontics ^*  (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

bone biology; cell biology; gene expression; osteoblast(s); osteoclast(s); osteonecrosis

Indexed keywords

ALENDRONIC ACID; BONE DENSITY CONSERVATION AGENT; BONE SIALOPROTEIN; COLLAGEN TYPE 1; EPHRIN B1; EPHRIN RECEPTOR; OSTEONECTIN;

ANIMAL; ARTICLE; BONE REMODELING; C57BL MOUSE; CELL COMMUNICATION; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; OSTEOBLAST; OSTEOCLAST;

ALENDRONATE; ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; CELL COMMUNICATION; CELLS, CULTURED; COLLAGEN TYPE I; EPHRIN-B1; GENE EXPRESSION REGULATION; INTEGRIN-BINDING SIALOPROTEIN; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOCLASTS; OSTEONECTIN; RECEPTORS, EPH FAMILY;

EID: 84856899193     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034511432170     Document Type: Article

References (28)

1. Allan EH, Hausler KD, Wei T, Gooi JH, Quinn JM, Crimeen-Irwin B, et al. EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts. J Bone Miner Res. 2008 ; 23: 1170-1181 (Pubitemid 352040173)
2. Chen J, Shapiro HS, Sodek J. Development expression of bone sialoprotein mRNA in rat mineralized connective tissues. J Bone Miner Res. 1992 ; 7: 987-997
3. Davy A, Aubin J, Soriano P. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004 ; 18: 572-583 (Pubitemid 38372813)
4. Davy A, Bush JO, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 ; 4: e315
5. Edwards CM, Mundy GR. Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sci. 2008 ; 5: 263-272
6. Fisher LW, Torchia DA, Fohr B, Young MF, Fedarko NS. Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. Biochem Biophys Res Commun. 2001 ; 280: 460-465 (Pubitemid 32912812)
7. Fleisch H. Development of bisphosphonates. Breast Cancer Res. 2002 ; 4: 30-34 (Pubitemid 34097554)
8. Hikita H, Miyazawa K, Tabuchi M, Kimura M, Goto S. Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats. J Bone Miner Metab. 2009 ; 27: 663-672
9. Huang RC, Khan SN, Sandhu HS, Metzl JA, Cammisa FP, Zheng F, et al. Alendronate inhibits spine fusion in a rat model. Spine (Phila Pa 1976). 2005 ; 30: 2516-2522 (Pubitemid 41669087)
10. Huja SS, Fernandez SA, Phillips C, Li Y. Zoledronic acid decreases bone formation without causing osteocyte death in mice. Arch Oral Biol. 2009 ; 54: 851-856
11. Hunter GK, Goldberg HA. Nucleation of hydroxyapatite by bone sialoprotein. Proc Natl Acad Sci USA. 1993 ; 90: 8562-8565 (Pubitemid 23277709)
12. Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, et al. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem. 2009 ; 284: 14637-14644
13. Iwata K, Li J, Follet H, Phipps RJ, Burr DB. Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia. Bone. 2006 ; 39: 1053-1058 (Pubitemid 44528380)
14. Kubek DJ, Burr DB, Allen MR. Ovariectomy stimulates and bisphosphonates inhibit intracortical remodeling in the mouse mandible. Orthod Craniofac Res. 2010 ; 13: 214-222
15. Malaval L, Wade-Gueye NM, Boudiffa M, Fei J, Zirngibl R, Chen F, et al. Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med. 2008 ; 205: 1145-1153 (Pubitemid 351679689)
16. Miao H, Strebhardt K, Pasquale EB, Shen TL, Guan JL, Wang B. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem. 2005 ; 280: 923-932
17. Noren NK, Yang NY, Silldorff M, Mutyala R, Pasquale EB. Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J. 2009 ; 422: 433-442
18. Orriss IR, Key ML, Colston KW, Arnett TR. Inhibition of osteoblast function in vitro by aminobisphosphonates. J Cell Biochem. 2009 ; 106: 109-118
19. Park IH, Ro J, Nam BH, Kwon Y, Lee KS. Potential antitumor effects of nitrogen-containing bisphosphonate in hormone receptor negative breast cancer patients with bone metastases. BMC Cancer. 2009 ; 9: 154
20. Pozzi S, Vallet S, Mukherjee S, Cirstea D, Vaghela N, Santo L, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 ; 15: 5829-5839
21. Samadfam R, Xia Q, Goltzman D. Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice. J Bone Miner Res. 2007 ; 22: 55-63 (Pubitemid 46032597)
22. Schneider JP. Bisphosphonates and low-impact femoral fractures: current evidence on alendronate-fracture risk. Geriatrics. 2009 ; 64: 18-23
23. Shimizu E, Selvamurugan N, Westendorf JJ, Olson EN, Partridge NC. HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression. J Biol Chem. 2010 ; 285: 9616-9626
24. Valverde P, Tu Q, Chen J. BSP and RANKL induce osteoclastogenesis and bone resorption synergistically. J Bone Miner Res. 2005 ; 20: 1669-1679 (Pubitemid 41243555)
25. van Beek ER, Cohen LH, Leroy IM, Ebetino FH, Lowik CW, Papapoulos SE. Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates. Bone. 2003 ; 33: 805-811 (Pubitemid 37406665)
26. Xing W, Kim J, Wergedal J, Chen ST, Mohan S. Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1. Mol Cell Biol. 2010 ; 30: 711-721
27. Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T, et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 2006 ; 4: 111-121 (Pubitemid 44138718)
28. Zou JX, Wang B, Kalo MS, Zisch AH, Pasquale EB, Ruoslahti E. An Eph receptor regulates integrin activity through R-Ras. Proc Natl Acad Sci USA. 1999 ; 96: 13813-13818