Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer
Baxevanis C, Reclos G, Gritzapis A, et al. Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer. 1993; 72:491-501. (Pubitemid 23193457)
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer
DOI 10.1002/ijc.1397
Kundu N, Yang Q, Dorsey R, et al. Increased cyclooxygenase- 2 (COX-2) expression and activity in a murine model of metastatic breast cancer. Int J Cancer. 2001;94:681-686. (Pubitemid 32695116)
Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
Kundu N, Ma X, Holt D, et al. Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function. Breast Cancer Res Treat. 2009;117:235-242.
Cyclooxygenase inhibitors modulate NK activities that control metastatic disease
DOI 10.1007/s00262-005-0669-2
Kundu N, Walser T, Ma X, et al. Cyclooxygenase inhibitors modulate NK activities that control metastatic disease. Cancer Immunol Immunother. 2005;54:981-987. (Pubitemid 41187706)
Prostaglandin E2 (PGE2) suppresses natural killer cell function through the PGE2 receptor EP4
Holt D, Ma X, Kundu N, et al. Prostaglandin E2 (PGE2) suppresses natural killer cell function through the PGE2 receptor EP4. Cancer Immunol, Immunother. 2011;60:1577-1586.
Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2
[Epub July 15]
Ma X, Kundu N, Collin P, et al. Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. Breast Cancer Res Treat. 2011. [Epub July 15].
PGE2 inhibits natural killer and gd T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling
Martinet L, Jean C, Dietrich G, et al. PGE2 inhibits natural killer and gd T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling. Biochem Pharmacol. 2010;80:838-845.
Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression
Su Y, Huang X, Raskovalova T, et al. Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. Cancer Immunol Immunother. 2008 57 1611-1623.
Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1
Zeidler R, Csanady M, Gires O, et al. Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1. FASEB J. 2000;14:661-668. (Pubitemid 30198565)