Fetal surgery for myelomeningocele: Trials and tribulations

Journal of Pediatric Surgery

Volumn 47, Issue 2, 2012, Pages 273-281

  Adzick, N Scott ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Fetal surgery; Hindbrain herniation; Hydrocephalus; Management of Myelomeningocele Study (MOMS); Myelomeningocele; Prenatal diagnosis; Spina bifida

Indexed keywords

ARTICLE; BRAIN DYSFUNCTION; CHROMOSOME DISORDER; EVOKED SOMATOSENSORY RESPONSE; FETUS SURGERY; GENETIC SCREENING; HUMAN; LAMINECTOMY; LIQUORRHEA; MENINGOMYELOCELE; NONHUMAN; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SPINA BIFIDA; SPINAL CORD LESION; ULTRASOUND;

EID: 84856860986     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2011.11.021     Document Type: Review

References (63)

1. L.E. Mitchell, N.S. Adzick, and J. Melchionne Spina bifida Lancet 364 2004 1885 1895
2. L.D. Botto, C.A. Moore, and M.J. Khoury Neural-tube defects N Engl J Med 341 1999 1509 1519
3. Medical Research Council Vitamin Research Study Group Prevention of neural tube defects: results of the Medical Research Council Vitamin Study Lancet 338 1991 131 137
4. CDC Knowledge and use of folic acid by women of childbearing age-United States, 1995 and 1998 MMWR Morb Mortal Wkly Rep 48 1999 325 327
5. L.D. Edmonds, and L.M. James Temporal trends in the prevalence of congenital malformations at birth based on the birth defects monitoring program, United States, 1979-1987 MMWR Morb Mortal Wkly Rep CDC Surveill Summ 39 1990 19 23
6. J.M. Lary, and L.D. Edmonds Prevalence of spina bifida at birth-United States, 1983-1990: a comparison of two surveillance systems MMWR Morb Mortal Wkly Rep CDC Surveil Summ 45 1996 15 26
7. G.M. Shaw, N.G. Jensvold, and C.R. Wasserman Epidemiologic characteristics of phenotypically distinct neural tube defects among 0.7 million California births, 1983-1987 Teratology 49 1994 143 149
8. H.E. Roberts, C.A. Moore, and J.D. Cragan Impact of prenatal diagnosis on the birth prevalence of neural tube defects, Atlanta, 1990-1991 Pediatrics 96 1995 880 883
9. E.M. Velie, and G.M. Shaw Impact of prenatal diagnosis and elective termination on prevalence and risk estimates of neural tube defects in California, 1989-1991 Am J Epidemiol 144 1996 473 479
10. D.A. Luthy, T. Wardinsky, and D.B. Shurtleff Cesarean section before the onset of labor and subsequent motor function in infants with myelomeningocele diagnosed antenatally N Engl J Med 324 1991 662 666
11. M. Caldarelli, C. DiRocco, and F. LaMarca Shunt complications in the first postoperative year in children with meningomyelocele Childs Nerv Syst 12 1996 748 754
12. P. Oakeshott, and G.M. Hunt Long-term outcome in open spina bifida Br J Gen Pract 53 2003 632 636
13. W. Oaks, and S. Gaskill Symptomatic Chiari malformations in childhood T. Park, Spinal Dysraphism 1992 Blackwell Scientific Publications, Inc Boston 104 125
14. G.M. Hunt Open spina bifida: outcome for a complete cohort treated unselectively and followed into adulthood Dev Med Child Neurol 32 1990 108 188
15. N.J. Waitzman, P.S. Romano, and R.M. Scheffler Estimates of the economic costs of birth defects Inquiry 31 1994 188 205
16. G.M. Hutchins, K.D. McGowan, and K.J. Blakemore Spinal dysraphia: not a neural tube defect? Am J Hum Genet 51 1992 A319
17. G.M. Hutchins, M. Meuli, and C. Meuli-Simmen Acquired spinal cord injury in human fetuses with myelomeningocele Pediatr Pathol Lab Med 16 1996 701 712
18. M.J. Korenromp, J.D. Van Good, and H.W. Bruinese Early fetal movements in myelomeningocele Lancet 1 1986 917 918
19. D.A. Sival, J.H. Begeer, and A.L. Staal-Schreinemachers Perinatal motor behaviour and neurological outcome in spina bifida aperta Early Hum Dev 50 1997 27 37
20. D. Pang, and M.S. Dias Cervical myelomeningoceles Neurosurgery 33 1993 363 372
21. L.N. Sutton Lipomyelomeningocele Neurosurg Clin North Am 6 1995 325 338
22. T. Duckworth, W.J. Sharrard, and J. Lister Hemimyelocele Dev Med Child Neurol 10 1968 69 75
23. M. Michejda Intrauterine treatment of spina bifida. Primate model Z Kinderchir 39 1984 259 261
24. D.S. Heffez, J. Aryanpur, and N.A. Rotellini Intrauterine repair of experimental surgically created spina bifida Neurosurg 32 1993 1005 1010
25. D.S. Heffez, J. Aryanpur, and G.M. Hutchins The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury Neurosurg 26 1990 987 992
26. D. Steifel, A.J. Copp, and M. Meuli Fetal spina bifida in a mouse model: loss of neural function in utero J Neurosurg 106 2007 213 221
27. D. Stiefel, and M. Meuli Scanning electron microscopy of fetal murine myelomeningocele reveals growth and development of the spinal cord in early gestation and neural tissue destruction around birth J Pediatr Surg 42 2007 1561 1565
28. M. Meuli, C. Meuli-Simmen, and C.D. Yingling Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep J Pediatr Surg 30 1995 1028 1032
29. M. Meuli, C. Meuli-Simmen, and C.D. Yingling In utero repair of experimental myelomeningocele spares neurologic function at birth J Pediatr Surg 31 1996 397 402
30. M. Meuli, C. Meuli-Simmen, and G.M. Hutchins In utero surgery rescues neurologic function at birth in sheep with spina bifida Nat Med 1 1995 342 347
31. C. Meuli-Simmen, M. Meuli, and G.M. Hutchins Fetal reconstructive surgery: experimental use of latissimus dorsi flap to correct myelomeningocele in utero Plast Reconstr Surg 96 1995 1007 1011
32. M. Meuli, C. Meuli-Simmen, and G.M. Hutchins The spinal cord lesion in human fetuses with myelomeningocele: implications for fetal surgery J Pediatr Surg 32 1997 448 452
33. B.W. Paek, D.L. Farmer, and C.C. Wilkinson Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs Am J Obstet Gynecol 183 2000 1119 1123
34. S. Bouchard, M.G. Davey, and N.E. Rintoul Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep J Pediatr Surg 38 2003 451 458
35. E. Danzer, U. Schwarz, and S. Wehrli Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathological analysis and magnetic resonance imaging Exp Neurol 194 2005 467 475
36. E. Danzer, D.A. Kiddoo, and R.A. Redden Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele Am J Physiol Renal Physiol 292 2007 F197 206
37. E. Danzer, A. Radu, and L.E. Robinson Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningocele Neurosci Lett 430 2008 157 162
38. E. Danzer, L. Zhang, and A. Radu Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury Am J Obstet Gynecol 204 2011 e1 e11
39. N.S. Adzick, and M.R. Harrison Fetal surgical therapy Lancet 343 1994 897 902
40. D.D. Cochrane, R.D. Wilson, and P. Steinbok Prenatal spinal evaluation and functional outcome of patients born with myelomeningocele: information for improved prenatal counselling and outcome prediction Fetal Diag Ther 11 1996 159 168
41. T.M. Quinn, A.M. Hubbard, and N.S. Adzick Prenatal magnetic resonance imaging enhances fetal diagnosis J Pediatr Surg 33 1998 553 558
42. C.J. Babcook, R.B. Goldstein, and R.A. Barth Prevalence of ventriculomegaly in association with myelomeningocele: correlation with gestational age and severity of posterior fossa deformity Radiol 190 1994 703 707
43. N.S. Adzick, L.N. Sutton, and T.M. Crombleholme Successful fetal surgery for spina bifida Lancet 352 1998 1675 1676
44. L.N. Sutton, N.S. Adzick, and L.T. Bilaniuk Improvement in hindbrain herniation by serial fetal MRI following fetal surgery for myelomeningocele JAMA 282 1999 1826 1831
45. J.P. Bruner, N. Tulipan, and R.L. Paschall Intrauterine repair of myelomeningocele, 'hindbrain restoration' and the incidence of shunt-dependent hydrocephalus JAMA 282 1999 1819 1825
46. N. Tulipan, L.N. Sutton, and J.P. Bruner The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus Pediatr Neurosurg 38 2003 27 33
47. N.S. Adzick, E.A. Thom, and C.Y. Spong A randomized trial of prenatal versus postnatal repair of myelomeningocele N Engl J Med 364 2011 993 1004
48. J. Rychik, Z. Tian, and M.S. Cohen Acute cardiovascular effects of fetal surgery in the human Circulation 21 2004 1549 1556
49. M.P. Johnson, N.S. Adzick, and N. Rintoul Fetal myelomeningocele repair: short-term clinical outcomes Am J Ob Gyn 189 2003 482 487
50. N.E. Rintoul, L.N. Sutton, and A.M. Hubbard A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention Pediatrics 109 2002 409 413
51. E. Danzer, M.P. Johnson, and M. Bebbington Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair Fetal Diagn Ther 22 2007 1 6
52. E. Danzer, R.S. Finkel, and N.E. Rintoul Reversal of hindbrain herniation after fetal surgery for myelomeningocele subsequently reduces the incidence and severity of brain-stem dysfunction and cranial nerve compression Neuropediatrics 41 2010 140 143
53. E. Danzer, M. Gerdes, and M. Bebbington Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery Fetal Diagn Ther 25 2009 47 53
54. E. Danzer, N.S. Adzick, and N.E. Rintoul Intraductal inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings J Neurosurg Pediatrics 6 2008 406 413
55. M.P. Johnson, M. Gerdes, and N.E. Rintoul Fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age Am J Obstet Gynecol 194 2006 1145 1150
56. E. Danzer, M. Gerdes, and D.M. Zarnow Preschool neurodevelopmental outcome of children following fetal myelomeningocele closure Am J Obstet Gynecol 202 2010 e1 e9
57. R.D. Wilson, M.P. Johnson, and A.W. Flake Maternal reproductive outcomes in pregnancies following an open fetal surgery pregnancy Am J Obstet Gynecol 191 2004 1430 1436
58. R.D. Wilson, K. Kamerand, and M.P. Johnson Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by maternal-fetal surgery Am J Obstet Gynecol 203 2010 e1 e6
59. J.P. Bruner, N.B. Tulipan, and W.O. Richards Endoscopic coverage of fetal open myelomeningocele in utero Am J Obstet Gynecol 176 1997 256 257
60. D.L. Farmer, C.S. von Koch, and W.J. Peacock In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes Arch Surg 138 2003 872 878
61. T. Kohl, and U. Gembruch Current status and prospects of fetoscopic surgery for spina bifida in human fetuses Fetal Diagn Ther 24 2008 318 320
62. R. Verbeek, A. Heep, and N. Maurits Does fetal endoscopic closure of the myelomeningocele prevent loss of neurologic function in spina bifida aperta? Cerebrospinal Fluid Res 7 Suppl 1 2010 S18
63. M. Watanabe, J. Jo, and A. Radu A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor Tissue Eng Part A 16 2010 1645 1646