Scanning electron microscopy of fetal murine myelomeningocele reveals growth and development of the spinal cord in early gestation and neural tissue destruction around birth

Journal of Pediatric Surgery

Volumn 42, Issue 9, 2007, Pages 1561-1565

  Stiefel, Dorothea ^a,b   Meuli, Martin ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Fetal surgery; Myelomeningocele; Neural tube defect; Spina bifida

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; MALE; MENINGOMYELOCELE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS TISSUE; NEUROPATHOLOGY; NEURULATION; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPINAL CORD;

ANIMALS; FEMALE; GESTATIONAL AGE; MALE; MENINGOMYELOCELE; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, SCANNING; NERVE TISSUE; PREGNANCY; SPINAL CORD;

EID: 34548451729     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2007.04.019     Document Type: Article

References (17)

1. Bouchard S., Davey M.G., Adzick N.S., et al. Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. J Pediatr Surg 38 (2003) 451-458
2. Dias M.S., and McLone D.G. Hydrocephalus in the child with dysraphism. Neurosurg Clin N Am 4 (1993) 715-726
3. Babcook C.J., Goldstein R.B., Filly R.A., et al. Prevalence of ventriculomegaly in association with myelomeningocele: correlation with gestational age and severity of posterior fossa deformity. Radiology 190 (1994) 703-707
4. Manning S.M., Jennings R., and Madsen J.R. Pathophysiology, prevention, and potential treatment of neural tube defects. Ment Retard Dev Disabil Res Rev 6 (2000) 6-14
5. Emery J.L., and Lendon R.G. Clinical implications of cord lesions in neurospinal dysraphism. Dev Med Child Neurol 14 Suppl 27 (1972) 45-51
6. Korenromp M.J., Van Gool J.D., and Bruinse H.W. Early fetal leg movements in myelomeningocele. Lancet 1 (1986) 917-918
7. Osaka K., Tanimura T., Matsumoto S., et al. Myelomeningocele before birth. J Neurosurg 49 (1978) 711-724
8. Heffez D.S., Aryanpur J., Freeman J.M., et al. The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury. Neurosurgery 26 (1990) 987-992
9. Hutchins G.M., Meuli M., Blakemore K.J., et al. Acquired spinal cord injury in human fetuses with myelomeningocele. Pediatr Pathol Lab Med 16 (1996) 701-712
10. Meuli M., Meuli-Simmen C., Adzick N.S., et al. The spinal cord lesion in human fetuses with myelomeningocele: implications for fetal surgery. J Pediatr Surg 32 (1997) 448-452
11. Stiefel D., Copp A.J., and Meuli M. Fetal Spina bifida in a mouse model: loss of neural function in utero. J Neurosurg 16 (2007) 213-221
12. McLone D.G., Dias M.S., Knepper P.A., et al. Pathologic changes in exposed neural tissue of fetal delayed splotch (Spd) mice. Childs Nerv Syst 13 (1997) 1-7
13. Michejda M. Intrauterine treatment of spina bifida: primate model. Z Kinderchir 39 (1984) 259-261
14. Drewek M.J., Bruner J.P., and Tulipan N. Quantitative analysis of the toxicity of human amniotic fluid to cultured rat spinal cord. Pediatr Neurosurg 27 (1997) 190-193
15. Olguner M., Akgur F.M., Ozer E., et al. Amniotic fluid exchange for the prevention of neural tissue damage in myelomeningocele: an alternative minimally invasive method to open in utero surgery. Pediatr Neurosurg 33(5) (2000) 252-256
16. Hirose S., Meuli-Simmen C., and Meuli M. Fetal surgery for myelomeningocele: panacea or peril?. World J Surg 27 1 (2003) 87-94
17. Walsh D.S., and Adzick N.S. Foetal surgery for spina bifida. Semin Neonatol 8 (2003) 197-205