Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility: A pilot study

Journal of Endocrinological Investigation

Volumn 34, Issue 10, 2011, Pages 747-752

  Palomba, S ^a   Falbo, A ^a   Espinola, S ^b   Rocca, M ^a   Capasso, S ^c   Cappiello, F ^c   Zullo, F ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Unit of Reproductive Medicine   (Italy)

Author keywords

DNA fragmentation; Gonadotropins; hpFSH; Male infertility; ROS; Subfertility

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; PROLACTIN; REACTIVE OXYGEN METABOLITE; TESTOSTERONE; THYROTROPIN;

ADULT; ARTICLE; CHROMATIN STRUCTURE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DRUG EFFECT; FOLLITROPIN BLOOD LEVEL; HUMAN; HUMAN CELL; IDIOPATHIC DISEASE; IDIOPATHIC MALE INFERTILITY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE INFERTILITY; OXIDATIVE STRESS; PILOT STUDY; SEMEN ANALYSIS; SPERM; SUBFERTILITY; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; TREATMENT RESPONSE;

ADULT; DNA FRAGMENTATION; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY, MALE; MALE; OXIDATIVE STRESS; PILOT PROJECTS; PROSPECTIVE STUDIES; REACTIVE OXYGEN SPECIES; SEMEN ANALYSIS; SPERMATOZOA;

EID: 84856857238     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7745     Document Type: Article

References (47)

1. Thonneau P, Marchand S, Tallec A, et al. Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989). Hum Reprod 1991, 6: 811-6.
2. Hull MG, Eddowes HA, Fahy U, et al. Expectations of assisted conception for infertility. BMJ 1992, 304: 1465-9.
3. Nygren KG, Andersen AN. Assisted reproductive technology in Europe, 1999. Results generated from European registers by ESHRE. Hum Reprod 2002, 17: 3260-74. (Pubitemid 35469284)
4. Padron OF, Brackett NL, Sharma RK, Lynne CM, Thomas AJ, Agarwal A. Seminal reactive oxygen species and sperm motility and morphology in men with spinal cord injury. Fertil Steril 1997, 67: 1115-20. (Pubitemid 27241907)
5. Krausz C, West K, Buckingham D, Aitken RJ. Development of a technique for monitoring the contamination of human semen samples with leukocytes. Fertil Steril 1992, 57: 1317-25.
6. Ollero M, Gil-Guzman E, Lopez MC, et al. Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. Hum Reprod 2001, 16: 1912-21. (Pubitemid 32916222)
7. Loft S, Kold-Jensen T, Hjollund NH, et al. Oxidative DNA damage in human sperm influences time to pregnancy. Hum Reprod 2003, 18: 1265-72. (Pubitemid 36740575)
8. Tesarik J, Mendoza-Tesarik R, Mendoza C. Sperm nuclear damage DNA change: update on the mechanism, diagnosis and treatment. Reprod Biomed Online 2006, 12: 715-21. (Pubitemid 43869374)
9. Aitken RJ, Fisher H. Reactive oxygen species generation and human spermatozoa: the balance of benefits and risk. Bioassays 1994, 16: 259-67. (Pubitemid 2073508)
10. De Lamirande E, Gagnon C. Impact of reactive species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod 1995, 10: 15-21.
11. Ozdamar AS, Soylu AG, Culha M, Gökalp A. Testicular oxidative stress. Effects of experimental varicocele in adolescent rats. Urol Int 2004, 73: 343-7. (Pubitemid 39664308)
12. Yumura Y, Iwasaki A, Saito K, Ogawa T, Hirokawa M. Effect of reactive oxygen species in semen on the pregnancy of infertile couples. Int J Urol 2009, 16: 202-7.
13. Attia AM, Al-Inany HG, Farquhar C, Proctor M. Gonadotrophins for idiopathic male factor subfertility. Cochrane Database Syst Rev. 2007, 4: CD005071.
14. rd ed. Cambridge University Press, Cambridge, 1992.
15. World Health Organization. WHO Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, New York, 1999.
16. Orio F Jr, Palomba S, Di Biase S, et al. Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate reductase in women with polycystic ovary sindrome. J Clin Endocrinol Metab 2003, 88: 673-9. (Pubitemid 36207807)
17. Kobayashi H, Gil-Guzman E, Mahran AM, et al. Quality control of reactive oxygen species measurement by luminol-dependent chemiluminescence assay. J Androl 2001, 22: 568-74. (Pubitemid 32623076)
18. Fernández JL, Muriel L, Goyanes V, et al. Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test. Fertil Steril 2005, 84: 833-42. (Pubitemid 41414567)
19. Nieschlag E, Simoni M, Gromoll J, Weinbauer GF. Role of FSH in the regulation of spermatogenesis: clinical aspects. Clin Endocrinol (Oxf) 1999, 51: 139-46. (Pubitemid 29378894)
20. Foresta C, Bettella A, Merico M, et al. FSH in the treatment of oligozoospermia. Mol Cell Endocrinol 2000, 30: 89-97. (Pubitemid 30201655)
21. Foresta C, Bettella A, Merico M, Garolla A, Ferlin A, Rossato M. Use of recombinant human follicle-stimulating hormone in the treatment of male factor infertility. Fertil Steril 2002, 77: 238-44. (Pubitemid 34083547)
22. Foresta C, Selice R, Ferlin A, Garolla A. Recombinant FSH in the treatment of oligozoospermia. Expert Opin Biol Ther 2009, 9: 659-66.
23. Foresta C, Bettella A, Garolla A, Ambrosini G, Ferlin A. Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study. Fertil Steril 2005, 84: 654-66.
24. Gualtieri AF, Mazzone GL, Rey RA, Schteingart HF. FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells. Int J Androl 2009, 32: 218-25.
25. Ochsendorf FR, Buhl R, Bästlein A, Beschmann H. Glutathione in spermatozoa and seminal plasma of infertile men. Hum Reprod 1998, 13: 353-9.
26. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 2008, 59: 2-11. (Pubitemid 350285578)
27. Coniglio JG. Testicular lipids. Prog Lipid Res 1994, 33: 387-401. (Pubitemid 24243353)
28. Sikka SC. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biosci 1996, 1: e78-86.
29. Venkatesh S, Deecaraman M, Kumar R, Shamsi MB, Dada R. Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility. Indian J Med Res 2009, 129: 127-37.
30. Lopes S, Jurisicova A, Sun JG, Casper RF. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum Reprod 1998, 13: 896-900. (Pubitemid 28239194)
31. Twigg J, Fulton N, Gòmez E. Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effective antioxidants. Hum Reprod 1998, 13: 1429-36. (Pubitemid 28310468)
32. Lin MH, Kuo-Kuang Lee R, Li SH, Lu CH, Sun FJ, Hwu YM. Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates. Fertil Steril 2008, 90: 352-9. (Pubitemid 352040692)
33. Appasamy M, Muttukrishna S, Pizzey AR, et al. Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reprod Biomed Online 2007, 14: 159-65. (Pubitemid 46296498)
34. Frank SA, Hurst LD. Mitochondria and male disease. Nature 1996, 383: 224.
35. Cummins JM, Jequier AM, Kan R. Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress? Mol Reprod Dev 1994, 37: 345-62. (Pubitemid 24086215)
36. St John JC, Cooke ID, Barratt CL. Mitochondrial mutations and male infertility. Nat Med 1997, 3: 124-5.
37. Moskovtsev SI, Willis J, White J, Mullen JB. Sperm DNA damage: correlation to severity of semen abnormalities. Urology 2009, 74: 789-93.
38. Smit M, Romijn JC, Wildhagen MF, Weber RF, Dohle GR. Sperm chromatin structure is associated with the quality of spermatogenesis in infertile patients. Fertil Steril 2010, 94: 1748-52.
39. Mehdi M, Khantouche L, Ajina M, Saad A. Detection of DNA fragmentation in human spermatozoa: correlation with semen parameters. Andrologia 2009, 41: 383-6.
40. Fernández JL, Muriel L, Goyanes V, et al. Halosperm is an easy, available, and cost-effective alternative for determining sperm DNA fragmentation. Fertil Steril 2005, 84: 860. (Pubitemid 41414572)
41. Chohan KR, Griffin JT, Lafromboise M, De Jonge CJ, Carrell DT. Comparison of chromatin assays for DNA fragmentation evaluation in human sperm. J Androl 2006, 27: 53-9. (Pubitemid 43106734)
42. Enciso M, Muriel L, Fernández JL, et al. Infertile men with varico̧cele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. J Androl 2006, 27: 106-11. (Pubitemid 43106742)
43. Velez de la Calle JF, Muller A, Walschaerts M, et al. Sperm deoxyribonucleic acid fragmentation as assessed by the sperm chromatin dispersion test in assisted reproductive technology programs: results of a large prospective multicenter study. Fertil Steril 2008, 90: 1792-9.
44. Saleh RA, Agarwal A, Nada EA, et al. Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Fertil Steril 2003, 79: 1597-605. (Pubitemid 36687939)
45. Henkel R, Kierspel E, Hajimohammad M, et al. DNA fragmentation of spermatozoa and assisted reproduction technology. Reprod Biomed Online 2003, 7: 477-84. (Pubitemid 37441707)
46. Ménézo YJ, Hazout A, Panteix G, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online 2007, 14: 418-21. (Pubitemid 46584375)
47. Tunc O, Thompson J, Tremellen K. Improvement in sperm DNA quality using an oral antioxidant therapy. Reprod Biomed Online 2009, 18: 761-8.