Antiplasmodial and antiulcer activities of Melanthera scadens

Asian Pacific Journal of Tropical Biomedicine

Volumn 2, Issue 1, 2012, Pages 16-20

  Okokon, Jude E ^a   Etebong, Ette O ^a   Udobang, John A ^a   Obot, Jackson ^a  

^a UNIVERSITY OF UYO   (Nigeria)

Author keywords

Antimalarial activity; Antiplasmodial activity; Antiulcer activity; Antiulcerogenic activity; Artesunate; Chemical constituent; Indomethacin; Melanthera scadens; Parasitaemia; Plasmodium berghei; Pyrimethamine

Indexed keywords

ANTIMALARIAL AGENT; ANTIULCER AGENT; ARTESUNATE; CHLOROQUINE; CIMETIDINE; MELANTHERA SCADENS EXTRACT; PLANT EXTRACT; PROPRANOLOL; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; ANTIULCER ACTIVITY; ARTICLE; ASTERACEAE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; IN VIVO STUDY; INFECTION PREVENTION; LD 50; MALE; MELANTHERA SCADENS; MOUSE; NONHUMAN; PARASITEMIA; PHYTOCHEMISTRY; PLANT LEAF; PLASMODIUM BERGHEI INFECTION; PRIORITY JOURNAL; RAT; STOMACH ULCER; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; FEMALE; ISOLATION AND PURIFICATION; MALARIA; PEPTIC ULCER; PLASMODIUM BERGHEI; TREATMENT OUTCOME;

ARTESUNATE; MELANTHERA; MUS; PLASMODIUM BERGHEI;

ANIMALS; ANTI-ULCER AGENTS; ANTIMALARIALS; ASTERACEAE; DISEASE MODELS, ANIMAL; FEMALE; MALARIA; MALE; MICE; PEPTIC ULCER; PLANT EXTRACTS; PLANT LEAVES; PLASMODIUM BERGHEI; RATS; TREATMENT OUTCOME;

EID: 84856848631     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(11)60182-2     Document Type: Article

References (19)

1. Burkill HM. The useful plants of west tropical Africa. 2nd ed. London: Royal Botanic Garden; 1985, p. 127.
2. Agyare C, Asase A, Lechtenberg M, Niehues M, Deters A, Hensi A. An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for woundhealing in Gosomtwi-Atwima-Kwanwoma area, Ghana. J Ethnopharmacol 2009; 125: 393-403.
3. Ajibesin KK, Ekpo BA, Bala DN, Essien EE, Adesanya SA. Ethnobotanical survey of Akwa Ibom State of Nigeria. J Ethnopharmacol 2008; 115: 387-408.
4. Guede ZN, Mambu L, Guede GF, Bodo B, Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. J Ethnopharmacol 2005; 98: 281-285.
5. Guede NZ, N 'guessan K, Dibie TE, Grellier P. Ethnopharmacological study of plants used to treat malaria intraditional medicine by Bete populations of Issia (Cote d'voire). J Pharm Sci Res 2010; 2(4): 216-227.
6. Adeseguna SA, Alabia SA, Olabanja PA, Alexander H, Coker B. Evaluation of antioxidant potential of Melanthera scandens. J Acupunct Meridian Stud 2010; 3(4): 267-271.
7. Offong E. Antidiabetic and hypolipidemic activities of Melanthera scadens (M.Sc. dissertation). University of Uyo, Uyo, Nigeria; 2011.
8. Penders A, Delaude C. Triterpenoids saponins from Melanthera scadens. Phytochemistry 1994; 37(3): 821-825.
9. Trease GE, Evans WC. Pharmacognosy. 13th ed. London: Bailliere Tindal; 1996, p. 683-684.
10. Miller LC, Tainter ML. Estimation of ED50 or LD50 values and their error using logarithmic-probit graph paper. Proc Soc Exp Biol Med 1944; 57: 261-264.
11. Okokon JE, Nwafor PA. Antiplasmodial activity of ethanolic root extract and fractions of Croton zambesicus. J Ethnopharmacol 2009; 121: 74-78.
12. Antia BS, Okokon JE, Etim EI, Umoh UF, Bassey EO. Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis. Indian J Pharmacol 2009;41(6): 258-261.
13. Nwafor PA, Bassey AL. Evaluation of antidiarrhoeal and antiulcerogenic potential of ethanolic extract of Carpolobia lutea leaves in rodents. J Ethnopharmacol 2007; 111: 619-624.
14. Okokon JE, Nwafor PA. Antiulcer and anticonvulsant activities of root extract of Croton zambesicus. Pak J Pharm Sci 2009; 22(4): 384-390.
15. Okokon JE, Umoh UF, Udobang JA, Etim EI. Antiulcerogenic activity of ethanolic leaf extract of Croton zambesicus in rats. Afr J Biomed Res 2010; 13: 119-123.
16. Christensen SB, Kharazmi A. Antimalarial natural products: isolation, characterization and biological properties. In: Tringali C. (ed.) Bioactive compounds from natural sources: isolation, characterization and biological properties. London: Taylor & Francis; 2001, p. 379-432.
17. Hiruma-Lima CA, Calvo TR, Rodriguez CM, Andrade F, Vilegas W, Brito ARM. Antiulcerogenic activity of Alchornea castaneaefolia effects on somatostatin, gastrin and prostaglandin.J Ethnopharmacol 2006; 104: 215-224.
18. Salim AS. Removing oxygen derived free radicals stimulateshealing of ethanol-induced erosive gastritis in the rats. Digestion 1990; 47: 24-28.
19. Borrelli F, Izzo AA. The plant kingdom as source of anti-ulcer remedies. Phytother Res 2000; 14: 581-591.