Evaluation of anti-diarrhoeal and anti-ulcerogenic potential of ethanol extract of Carpolobia lutea leaves in rodents

Journal of Ethnopharmacology

Volumn 111, Issue 3, 2007, Pages 619-624

  Nwafor, Paul A ^a   Bassey, Augustine I L ^a  

^a UNIVERSITY OF UYO   (Nigeria)

Author keywords

Anti diarroheal; Anti ulcerogenic; Carpolobia lutea leaves; Ethanol extract; Rodents

Indexed keywords

ALCOHOL; ALPHA 2 ADRENERGIC RECEPTOR; ANTHRAQUINONE DERIVATIVE; CARDIAC GLYCOSIDE; CARPOLOBIA LUTEA EXTRACT; CASTOR OIL; CHOLINERGIC RECEPTOR; CIMETIDINE; DIPHENOXYLATE; FLAVONOID; INDOMETACIN; PLANT EXTRACT; SAPONIN DERIVATIVE; TANNIN DERIVATIVE; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG ACTIVITY; DRUG MECHANISM; INTESTINE TRANSIT TIME; INTESTINE ULCER; LD 50; MOUSE; NONHUMAN; POLYGALACEAE; RAT;

ACETYLCHOLINE; ANIMALS; ANTI-ULCER AGENTS; ANTIDIARRHEALS; DIARRHEA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL TRANSIT; LETHAL DOSE 50; MEDICINE, AFRICAN TRADITIONAL; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; POLYGALACEAE; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; STOMACH ULCER;

CARPOLOBIA; RODENTIA;

EID: 34247216261     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.01.019     Document Type: Article

References (40)

1. Aguwa C.N., and Nwako S.O. Preliminary studies on the root extracts of Nauclea latifolia Smith, for anti-ulcer properties. Nigerian Journal of Pharmaceutical Sciences 4 (1988) 16-23
2. Aguwu C.N., and Okunji C.O. Gastrointestinal Studies of Pyrenacantha staudii leaf extracts. Journal of Ethnopharmacology 15 (1986) 45-55
3. Alphin R.S., and Ward. J.W. Action of hexopyrronium bromide on gastric secretion in dogs and on gastric secretion and ulceration in rats. Archieves Internationales de Pharmacodynamie et de Therapie 270 (1967) 128-140
4. Bhargava K.P., Gupta M.B., and Tangri K.K. Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone. European Journal of Pharmacology 22 (1973) 191-195
5. Capasso F., DeRuggiero G., DiRosa M., and Sorrentino L. Ricerche farmacologiche sulla 4-amino-5-cloro-4-(2 dietilaminoetil) 2-metossi-benzamide. Bollettino Chimico Farmaceutico 115 (1976) 649-657
6. Cho C.H., Ogle C.W., and Sevila E.L. The protective effect of Sulphasalazine against ethanol-induced gastric damage in rats. British Journal of Pharmacology 92 (1987) 31-38
7. Cho C.H., Hua M.F., Chou C.K., and Ho L.T. Protection of zinc sulphate against necrosis induced by ethanol in rats. Proceedings of Netherland Science Council and Royal Society 7 (1983) 261-267
8. In: Clarke E.G.C. (Ed). Isolation and Identification of Drugs vol. 2 (1975), Pharmaceutical Press, London p. 905
9. DiCarlo G.D., Mascolo N., Izzo A.A., Capasso F., and Autore G. Effects of Quercetin on gastrointestinal tract in rats and mice. Phytotherapy Research 8 (1994) 42-45
10. Dreyling K.W., Lange K., Peskar B.A., and Peskar B.M. Release of leukotrienes by rat and human gastric mucosa and its pharmacological modification. British Journal of Pharmacology Proceeding Supplement 88 (1986) 236
11. Evbuonwa M.I., and Bolarinwa A.F. Effect of diet on indomethacin-induced peptic ulceration in pregnant rats. Nigerian Journal of Physiological Sciences 6 (1990) 189-191
12. Ferreira S.J., and Vane J.R. New aspects of the mode of actions of NSAIDS. Annual Review of Pharmacology 14 (1974) 57-70
13. Garner A., Flemstrom G., and Heylings J.R. Effects of anti-inflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphebian isolated gastric mucosa. Gastroenterology 77 (1979) 451-457
14. Guth P.H., Paulsen G., and Nagata H. Histologic and microcirculatory changes in alcohol-induced gastric lesion in rat. Effect of prostaglandin cytoprotection. Gastroenterology 87 (1984) 1083-1090
15. Hashizume T., Hirokawa K., Aibara S., Ogawa H., and Kashara A. Pharmacological and histological studies of gastric mucosa lesions induced by serotonin in rats. Archieves Internationales de Pharmacodynamie et de Therapie 236 (1978) 96-108
16. Hiruma-Lima C.A., Calvo T.R., Rodrigues C.M., Andrade F.D.P., Vilegas W., and Brito A.R.M.S. Antiulcerogenic activity of Alchornea castaneaefolia: effects on somatostatin, gastrin and prostaglandin. Journal of Ethnopharmacology 104 (2006) 215-224
17. Hsu W.H. Xylazine induced delay in small intestine transit in mice. European Journal of Pharmacology 83 (1982) 55-60
18. Iwu M.M., and Anyanwu B.N. Phytotherapeutic profile of Nigerian herbs 1. Anti-inflammatory and anti-arthritic agents. Journal of Ethnopharmacology 63 (1982) 263-274
19. John T.A., and Onabanjo A.O. Gastroprotective effects of an aqueous extract of Entandrophragma utile bark in experimental ethanol-induced peptic ulceration in mice and rats. Journals of Ethnopharmacology 29 (1990) 87-93
20. Konturek S.J., Redecki T., Piastucki I., Brzozowski T., and Drozdowicz D. Gastroprotection by colloidal bismuth subcitrate (De-nol) and sucralfate. Role of endogenous prostaglandins. Gut 228 (1987) 201-205
21. Lewis D.A., and Hanson D. Anti-ulcer drugs of plant origin. Progress in Medicinal Chemistry 28 (1991) 208-210
22. Lorke D. A new approach to practical acute toxicity testing. Archives Toxicology 53 (1983) 275-289
23. Menguy R., and Desbaillets L. Role of inhibition of gastric mucous secretion in the phenomenon of gastric mucosal injury by indomethacin. American Journal of Digestive Diseases 12 (1967) 862-866
24. Mitaine-Offer A., Miyamoto T., Khan I.A., Delaude C., and Dubois M. Three new triterpenes saponins from two species of Carpolabia. Journal of Natural Products 65 (2002) 533-557
25. Nwafor P.A., Effraim K.D., and Jacks T.W. Gastroprotective effects of aqueous extract of Khaya senegalensis bark on indomethacin-induced ulceration in rats. West African Journal of Pharmacology and Drug Research 12 (1996) 46-50
26. Nwafor P.A., Okwuasaba F.K., and Binda L.G. Antidarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. Journal of Ethnopharmacology 72 (2000) 421-427
27. Nwafor P.A., and Okwuasaba F.K. Effect of methanolic extract of Cassia nigricans leaves on gastrointestinal tract. Fitoterapia 72 (2001) 206-214
28. Nwafor P.A., Jacks T.W., Ekanem A.U., and Ching F.P. Antiulcerogenic and antidiarrhoeal potentials of Pausinystalia macroceras stem-bark in rats. Nigerian Journal of Natural Product and Medicine 9 (2005) 66-70
29. Nwodo O.F.C., and Alumanah E.O. Studies of Abrus precatorius seed 11: antidarrhoeal activity. Journal of Ethnopharmacology 31 (1991) 395-398
30. Odebiyi O.O., and Sofowora E.A. Phytochemical screening of Nigerian medicinal plants. Lloydia 41 (1978) 234-235
31. Oliver B. Medicinal Plants in Nigeria (1960), Nigeria College of Arts and Science and Technology, Ibadan p. 358
32. 4 in rat gastric mucosa. Prostaglandins 31 (1986) 283-293
33. Robert A., Nezamis J.E., Lancaster C., Hanchar A.I., and Kleppre M.S. Enteropooling assay: a test for diarrhoea produced by prostaglandins. Prostaglandins 11 (1976) 809-814
34. Rujjanawate C., Kanjanapothi D., Amornlerdpison D., and Pojanagaroon S. Anti-gastric ulcer effect of Kaempferia parviflora. Journal of Ethnopharmacology 102 (2005) 120-122
35. Ruwarts M.J., Kleppre M.S., and Rush B.D. Clonidine delays small intestine transit in rat. Journal of Pharmacology and Experimental Therapeutics 3 (1980) 487-490
36. Szabo S., Trier J.S., Brown A., and Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88 (1985) 228-236
37. Trease, G.E., Evans, W.C., 1989. Pharmacognosy. English Language Book Society, 13th ed. Bailliere Tindall, London, pp. 683-684.
38. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin like drugs. Nature New Biology 231 (1971) 232-235
39. 2α, and thromboxane mimetic (U-4669) on rat submucosal microcirculation in vivo. American Journal of Physiology 248 (1985) G580-G586
40. Zaidi S.H., and Mukerji B. Experimental peptic ulceration. Part 1. The significance of mucous barrier. Indian Journal of Medical Research 46 (1958) 27-37