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Volumn 24, Issue 2, 2012, Pages 130-136

Older age, poor performance status and major comorbidities: How to treat high-risk patients with advanced nonsmall cell lung cancer

Author keywords

advanced nonsmall cell lung cancer; elderly; poor performance status

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; ETOPOSIDE; GEMCITABINE; NAVELBINE; PACLITAXEL; PEMETREXED; PLATINUM; VASCULOTROPIN;

EID: 84856835072     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32834ea6ea     Document Type: Review
Times cited : (19)

References (53)
  • 2
    • 84856858190 scopus 로고    scopus 로고
    • SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. Bethesda, MD: National Cancer Institute
    • Ries LAG, Melbert D, Krapcho M, et al., editors. SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. Bethesda, MD: National Cancer Institute. http://seer.cancer.gov/csr/1975-2005/.
    • Ries, L.A.G.1    Melbert, D.2    Krapcho, M.3
  • 3
    • 37649004819 scopus 로고    scopus 로고
    • Lung cancer in elderly patients: An analysis of the surveillance, epidemiology, and end results database
    • Owonikoko TK, Ragin CC, Belani CP, et al. Lung cancer in elderly patients: An analysis of the surveillance, epidemiology, and end results database. J Clin Oncol 2007; 25:5570-5577.
    • (2007) J Clin Oncol , vol.25 , pp. 5570-5577
    • Owonikoko, T.K.1    Ragin, C.C.2    Belani, C.P.3
  • 4
    • 80155174231 scopus 로고    scopus 로고
    • Efficacy and treatment tolerance in older patients with NSCLC: A meta-Analysis of five phase III randomized trials conducted by the hellenic oncology research group
    • Pooled data from five clinical trials of the Hellenic Oncology Research Group were analyzed; 424 patients (23%) were at least 70 years. There was a higher risk for death in older patients. However, when the analysis was carried out after omitting a trial that showed a different trend, no difference was observed. Older patients experienced higher toxicity
    • Pallis AG, Karampeazis A, Vamvakas L et al. Efficacy and treatment tolerance in older patients with NSCLC: A meta-Analysis of five phase III randomized trials conducted by the hellenic oncology research group. Ann Oncol 2011; 22:2448-2455. Pooled data from five clinical trials of the Hellenic Oncology Research Group were analyzed; 424 patients (23%) were at least 70 years. There was a higher risk for death in older patients. However, when the analysis was carried out after omitting a trial that showed a different trend, no difference was observed. Older patients experienced higher toxicity.
    • (2011) Ann Oncol , vol.22 , pp. 2448-2455
    • Pallis, A.G.1    Karampeazis, A.2    Vamvakas, L.3
  • 5
    • 4444249171 scopus 로고    scopus 로고
    • An overview of 48 elderly-specific clinical trials of systemic chemotherapy for advanced non-small cell lung cancer
    • DOI 10.1016/j.lungcan.2004.02.018, PII S0169500204001114
    • Hotta K, Ueoka H, Kiura K, et al. An overview of 48 elderly-specific clinical trials of systemic chemotherapy for advanced nonsmall cell lung cancer. Lung Cancer 2004; 46:61-76. (Pubitemid 39201385)
    • (2004) Lung Cancer , vol.46 , Issue.1 , pp. 61-76
    • Hotta, K.1    Ueoka, H.2    Kiura, K.3    Tabata, M.4    Tanimoto, M.5
  • 7
    • 77952311362 scopus 로고    scopus 로고
    • Chemotherapy and survival benefit in elderly patients with advanced nonsmall-cell lung cancer
    • Davidoff AJ, Tang M, Seal B, Edelman MJ. Chemotherapy and survival benefit in elderly patients with advanced nonsmall-cell lung cancer. J Clin Oncol 2010; 28:2191-2197.
    • (2010) J Clin Oncol , vol.28 , pp. 2191-2197
    • Davidoff, A.J.1    Tang, M.2    Seal, B.3    Edelman, M.J.4
  • 8
    • 77449086119 scopus 로고    scopus 로고
    • Adverse events among the elderly receiving chemotherapy for advanced nonsmall-cell lung cancer
    • Chrischilles EA, Pendergast JF, Kahn KL, et al. Adverse events among the elderly receiving chemotherapy for advanced nonsmall-cell lung cancer. J Clin Oncol 2009; 28:620-627.
    • (2009) J Clin Oncol , vol.28 , pp. 620-627
    • Chrischilles, E.A.1    Pendergast, J.F.2    Kahn, K.L.3
  • 10
    • 14644396447 scopus 로고    scopus 로고
    • Chemotherapy use, outcomes, and costs for older persons with advanced non-small-cell lung cancer: Evidence from surveillance, epidemiology and end results-medicare
    • DOI 10.1200/JCO.2004.05.031
    • Ramsey SD, Howlader N, Etzioni RD, Donato B. Chemotherapy use, outcomes, and costs for older persons with advanced nonsmall-cell lung cancer: Evidence from surveillance, epidemiology and end results-medicare. J Clin Oncol 2004; 22:4971-4978. (Pubitemid 46638623)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.24 , pp. 4971-4978
    • Ramsey, S.D.1    Howlader, N.2    Etzioni, R.D.3    Donato, B.4
  • 11
    • 0006453669 scopus 로고    scopus 로고
    • Effects of vinorelbine on quality of life and survival of elderly patients with advanced nonsmall-cell lung cancer
    • The elderly lung cancer vinorelbine italian study group
    • The elderly lung cancer vinorelbine italian study group. Effects of vinorelbine on quality of life and survival of elderly patients with advanced nonsmall-cell lung cancer. J Natl Cancer Inst 1999; 91:66-72.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 66-72
  • 15
    • 33749077728 scopus 로고    scopus 로고
    • Elderly patients benefit from second-line cytotoxic chemotherapy: A subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer
    • DOI 10.1200/JCO.2006.06.7835
    • Weiss GJ, Langer C, Rosell R, et al. Elderly patients benefit from second-line cytotoxic chemotherapy: A subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced nonsmall-cell lung cancer. J Clin Oncol 2006; 24:4405-4411. (Pubitemid 46630978)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.27 , pp. 4405-4411
    • Weiss, G.J.1    Langer, C.2    Rosell, R.3    Hanna, N.4    Shepherd, F.5    Einhorn, L.H.6    Nguyen, B.7    Paul, S.8    McAndrews, P.9    Bunn Jr., P.A.10    Kelly, K.11
  • 17
    • 0035195433 scopus 로고    scopus 로고
    • Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced nonsmall cell lung cancer. A southern italy cooperative oncology group (SICOG) phase III trial
    • Frasci G, Lorusso V, Panza N, et al. Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced nonsmall cell lung cancer. a southern italy cooperative oncology group (SICOG) phase III trial. Lung Cancer 2001; 34 (Suppl 4):S65-S69.
    • (2001) Lung Cancer , vol.34 , Issue.SUPPL. 4
    • Frasci, G.1    Lorusso, V.2    Panza, N.3
  • 18
    • 35648934612 scopus 로고    scopus 로고
    • Weekly docetaxel versus docetaxel/gemcitabine in the treatment of elderly or poor performance status patients with advanced nonsmall cell lung cancer: A randomized phase 3 trial of the Minnie Pearl Cancer Research Network
    • DOI 10.1002/cncr.23019
    • Hainsworth JD, Spigel DR, Farley C, et al. Weekly docetaxel versus docetaxel/ gemcitabine in the treatment of elderly or poor performance status patients with advanced nonsmall cell lung cancer: A randomized phase 3 trial of the minnie pearl cancer research network. Cancer 2007; 110:2027-2034. (Pubitemid 350036863)
    • (2007) Cancer , vol.110 , Issue.9 , pp. 2027-2034
    • Hainsworth, J.D.1    Spigel, D.R.2    Farley, C.3    Shipley, D.L.4    Bearden, J.D.5    Gandhi, J.6    Houston, G.A.7    Greco, F.A.8
  • 19
    • 0033950286 scopus 로고    scopus 로고
    • Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: Results of an eastern cooperative oncology group trial
    • Bonomi P, Kim K, Fairclough D, et al. Comparison of survival and quality of life in advanced nonsmall-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: Results of an eastern cooperative oncology group trial. J Clin Oncol 2000; 18:623-631. (Pubitemid 30078543)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.3 , pp. 623-631
    • Bonomi, P.1    Kim, K.2    Fairclough, D.3    Cella, D.4    Kugler, J.5    Rowinsky, E.6    Jiroutek, M.7    Johnson, D.8
  • 20
    • 0037028750 scopus 로고    scopus 로고
    • Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: Implications of Eastern Cooperative Oncology Group 5592, a randomized trial
    • Langer CJ, Manola J, Bernardo P, et al. Cisplatin-based therapy for elderly patients with advanced nonsmall-cell lung cancer: Implications of eastern cooperative oncology group 5592, a randomized trial. J Natl Cancer Inst 2002; 94:173-181. (Pubitemid 34162751)
    • (2002) Journal of the National Cancer Institute , vol.94 , Issue.3 , pp. 173-181
    • Langer, C.J.1    Manola, J.2    Bernardo, P.3    Kugler, J.W.4    Bonomi, P.5    Cella, D.6    Johnson, D.H.7
  • 22
    • 0242382971 scopus 로고    scopus 로고
    • Age-specific subanalysis of ECOG 1594: Fit elderly patients (70-80 YRS) with NSCLC do as well as younger pts s70)
    • abstr 2571
    • Langer C, Vangel M, Schiller JH. Age-specific subanalysis of ECOG 1594: Fit elderly patients (70-80 YRS) with NSCLC do as well as younger pts (
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Langer, C.1    Vangel, M.2    Schiller, J.H.3
  • 24
    • 29144460972 scopus 로고    scopus 로고
    • Elderly subgroup analysis of a randomized phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for first-line treatment of advanced nonsmall cell lung carcinoma (TAX 326)
    • DOI 10.1002/cncr.21495
    • Belani CP, Fossella F. Elderly subgroup analysis of a randomized phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for first-line treatment of advanced nonsmall cell lung carcinoma (TAX 326). Cancer 2005; 104:2766-2774. (Pubitemid 41798287)
    • (2005) Cancer , vol.104 , Issue.12 , pp. 2766-2774
    • Belani, C.P.1    Fossella, F.2
  • 26
    • 68549117356 scopus 로고    scopus 로고
    • Randomized controlled trial comparing docetaxel (D)-cisplatin (P) combination with D alone in elderly patients (pts) with advanced nonsmall cell lung cancer (NSCLC): JCOG0207
    • abstr 7629)
    • Tsukada H, Yokoyama A, Nishiwaki Y. Randomized controlled trial comparing docetaxel (D)-cisplatin (P) combination with D alone in elderly patients (pts) with advanced nonsmall cell lung cancer (NSCLC): JCOG0207. J Clin Oncol 2007; 25:18s (suppl; abstr 7629).
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Tsukada, H.1    Yokoyama, A.2    Nishiwaki, Y.3
  • 27
    • 84856888413 scopus 로고    scopus 로고
    • Randomized phase III trial comparing weekly docetaxel (D)-cisplatin (P) combination with triweekly D alone in elderly patients (pts) with advanced nonsmall cell lung cancer (NSCLC): An intergroup trial of JCOG0803/WJOG4307.L
    • abstr 7509. This study compared cisplatin-docetaxel combination with docetaxel alone (given q3 weeks) in chemotherapy-naive patients more than 70 years, with performance status0-1. This study failed to demonstrate any advantage of the addition of weekly P to single-Agent D in first-line chemotherapy for elderly advanced NSCLC patients
    • Abe T, Yokoyama A, Takeda K. Randomized phase III trial comparing weekly docetaxel (D)-cisplatin (P) combination with triweekly D alone in elderly patients (pts) with advanced nonsmall cell lung cancer (NSCLC): An intergroup trial of JCOG0803/WJOG4307L. J Clin Oncol 2011; 29 (suppl):abstr 7509. This study compared cisplatin-docetaxel combination with docetaxel alone (given q3 weeks) in chemotherapy-naive patients more than 70 years, with performance status 0-1. This study failed to demonstrate any advantage of the addition of weekly P to single-Agent D in first-line chemotherapy for elderly advanced NSCLC patients.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Abe, T.1    Yokoyama, A.2    Takeda, K.3
  • 29
    • 84886659143 scopus 로고    scopus 로고
    • Meta-Analysis of efficacy and safety of singleagent and doublet chemotherapy with or without platinum in advanced nonsmall cell lung cancer in the elderly
    • Meta-Analysis of 12 studies included 2530 patients (mean age 74 years). One-year OS was significantly improved with doublet chemotherapy, specifically when including platinum, compared with single-Agent therapy. Hematological sideeffects were higher in the elderly
    • Guetz GD, Uzzan B, Nicolas P. Meta-Analysis of efficacy and safety of singleagent and doublet chemotherapy with or without platinum in advanced nonsmall cell lung cancer in the elderly. J Clin Oncol 2011; 29. Meta-Analysis of 12 studies included 2530 patients (mean age 74 years). One-year OS was significantly improved with doublet chemotherapy, specifically when including platinum, compared with single-Agent therapy. Hematological sideeffects were higher in the elderly.
    • (2011) J Clin Oncol , pp. 29
    • Guetz, G.D.1    Uzzan, B.2    Nicolas, P.3
  • 30
    • 38649124303 scopus 로고    scopus 로고
    • Randomized, phase III study of weekly paclitaxel in combination with carboplatin versus standard every-3-weeks administration of carboplatin and paclitaxel for patients with previously untreated advanced non-small-cell lung cancer
    • DOI 10.1200/JCO.2007.13.1912
    • BelaniCP,RamalingamS, PerryMC, et al.Randomized, phase III study ofweekly paclitaxel incombination with carboplatin versus standardevery-3- weeksadministration of carboplatin and paclitaxel for patients with previously untreated advanced nonsmall-cell lung cancer. J Clin Oncol 2008; 26:468-473. (Pubitemid 351171701)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.3 , pp. 468-473
    • Belani, C.P.1    Ramalingam, S.2    Perry, M.C.3    LaRocca, R.V.4    Rinaldi, D.5    Gable, P.S.6    Tester, W.J.7
  • 31
    • 49049113050 scopus 로고    scopus 로고
    • Comparison of outcomes for elderly patients treated with weekly paclitaxel in combination with carboplatin versus the standard 3-weekly paclitaxel and carboplatin for advanced nonsmall cell lung cancer
    • Ramalingam S, Perry MC, La Rocca RV, et al. Comparison of outcomes for elderly patients treated with weekly paclitaxel in combination with carboplatin versus the standard 3-weekly paclitaxel and carboplatin for advanced nonsmall cell lung cancer. Cancer 2008; 113:542-546.
    • (2008) Cancer , vol.113 , pp. 542-546
    • Ramalingam, S.1    Perry, M.C.2    La Rocca, R.V.3
  • 32
    • 80052964872 scopus 로고    scopus 로고
    • Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced nonsmall-cell lung cancer: IFCT-0501 randomised, phase 3 trial
    • The first prospective trial to successfully compare platinum-based combination regimen to single agent chemotherapy in elderly patients (>70 years). Despite increased toxic effects, platinum-based doublet chemotherapy was associated with survival benefit compared with vinorelbine or gemcitabine monotherapy in elderly patients with NSCL.C.
    • Quoix E, Zalcman G, Oster JP, et al. Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced nonsmall-cell lung cancer: IFCT-0501 randomised, phase 3 trial. Lancet 2011; 378:1079-1088. The first prospective trial to successfully compare platinum-based combination regimen to single agent chemotherapy in elderly patients (>70 years). Despite increased toxic effects, platinum-based doublet chemotherapy was associated with survival benefit compared with vinorelbine or gemcitabine monotherapy in elderly patients with NSCLC.
    • (2011) Lancet , vol.378 , pp. 1079-1088
    • Quoix, E.1    Zalcman, G.2    Oster, J.P.3
  • 33
    • 83455167488 scopus 로고    scopus 로고
    • Survival results of a randomized, phase III trial of nab-paclitaxel and carboplatin compared with cremophorbased paclitaxel and carboplatin as first-line therapy in advanced nonsmall cell lung cancer
    • abstr 7551. A post-hoc analysis of a phase III trial comparing weekly nab-paclitaxel in combination with carboplatin to conventional combination paclitaxel-carboplatin at 3-week intervals demonstrated an improvedOS survival in patients 70 years of age or older receiving nab-paclitaxel
    • Socinski MA, Bondarenko IN, Karaseva NA. Survival results of a randomized, phase III trial of nab-paclitaxel and carboplatin compared with cremophorbased paclitaxel and carboplatin as first-line therapy in advanced nonsmall cell lung cancer. J Clin Oncol 2011; 29 (suppl):abstr 7551. A post-hoc analysis of a phase III trial comparing weekly nab-paclitaxel in combination with carboplatin to conventional combination paclitaxel-carboplatin at 3-week intervals demonstrated an improvedOS survival in patients 70 years of age or older receiving nab-paclitaxel.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Socinski, M.A.1    Bondarenko, I.N.2    Karaseva, N.A.3
  • 36
    • 44249121733 scopus 로고    scopus 로고
    • Erlotinib for advanced nonsmallcell lung cancer in the elderly: An analysis of the national cancer institute of canada clinical trials group study BR.21
    • Wheatley-Price P, Ding K, Seymour L, et al. Erlotinib for advanced nonsmallcell lung cancer in the elderly: An analysis of the national cancer institute of canada clinical trials group study BR.21. J Clin Oncol 2008; 26:2350-2357.
    • (2008) J Clin Oncol , vol.26 , pp. 2350-2357
    • Wheatley-Price, P.1    Ding, K.2    Seymour, L.3
  • 38
    • 78651104046 scopus 로고    scopus 로고
    • Topical: Randomized phase III trial of erlotinib compared with placebo in chemotherapy-naive patients with advanced nonsmall cell lung cancer (NSCLC) and unsuitable for first-line chemotherapy
    • abstr 7504). Chemo-naive NSCLC patients (ECOG performance status 2/3 or performance status 0/1 unfit for platinum chemotherapy; stage IIIB/IV) were randomized to erlotinib plus BSC or placebo plus BSC. Overall, erlotinib and BSC did not improve OS, but there was some evidence of benefit for PFS
    • Lee S, Rudd R, Khan I. Topical: Randomized phase III trial of erlotinib compared with placebo in chemotherapy-naive patients with advanced nonsmall cell lung cancer (NSCLC) and unsuitable for first-line chemotherapy. J Clin Oncol 2010; 28:15s (suppl; abstr 7504). Chemo-naive NSCLC patients (ECOG performance status 2/3 or performance status 0/1 unfit for platinum chemotherapy; stage IIIB/IV) were randomized to erlotinib plus BSC or placebo plus BSC. Overall, erlotinib and BSC did not improve OS, but there was some evidence of benefit for PFS.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Lee, S.1    Rudd, R.2    Khan, I.3
  • 39
    • 39749087795 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2
    • DOI 10.1200/JCO.2007.13.2720
    • Lilenbaum R, Axelrod R, Thomas S, et al. Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced nonsmall-cell lung cancer and a performance status of 2. J Clin Oncol 2008; 26:863-869. (Pubitemid 351398077)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.6 , pp. 863-869
    • Lilenbaum, R.1    Axelrod, R.2    Thomas, S.3    Dowlati, A.4    Seigel, L.5    Albert, D.6    Witt, K.7    Botkin, D.8
  • 40
    • 80052467761 scopus 로고    scopus 로고
    • Erlotinib versus carboplatin/vinorelbine in elderly patients (age 70 or older) with advanced nonsmall cell lung carcinoma (NSCLC): A randomized phase II study of the German Thoracic Oncology Working Group
    • abstr 7565) In this randomized phase II trial, elderly patients (70 years) with advanced NSCLC were randomized to erlotinib or carboplatin+vinorelbine. Chemotherapy had an increased efficacy compared with erlotinib alone in an unselected patient population
    • Reck M, Von Pawel J, Fischer JR. Erlotinib versus carboplatin/vinorelbine in elderly patients (age 70 or older) with advanced nonsmall cell lung carcinoma (NSCLC): A randomized phase II study of the German Thoracic Oncology Working Group. J Clin Oncol 2010; 28:15s (suppl; abstr 7565). In this randomized phase II trial, elderly patients (70 years) with advanced NSCLC were randomized to erlotinib or carboplatin+vinorelbine. Chemotherapy had an increased efficacy compared with erlotinib alone in an unselected patient population.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Reck, M.1    Von Pawel, J.2    Fischer, J.R.3
  • 41
    • 80052429243 scopus 로고    scopus 로고
    • B. LCPreliminary results of a randomized phase II trial of first-line treatment of gemcitabine (G) versus erlotinib (E) versus gemcitabine and erlotinib (GE) in patients 70 years or older with advanced nonsmall cell lung cancer (NSCLC)
    • abstr 7576)
    • Stinchcombe T, Bradford DS, B. LC. Preliminary results of a randomized phase II trial of first-line treatment of gemcitabine (G) versus erlotinib (E) versus gemcitabine and erlotinib (GE) in patients 70 years or older with advanced nonsmall cell lung cancer (NSCLC). J Clin Oncol 2010; 28:15s (suppl; abstr 7576).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Stinchcombe, T.1    Bradford, D.S.2
  • 42
    • 80052447876 scopus 로고    scopus 로고
    • A multicenter phase II randomized study of docetaxel (D)/gemcitabine (G) weekly followed by erlotinib (E) after progression versus erlotinib followed by docetaxel/gemcitabine after progression in advanced nonsmall cell lung cancer (NSCLC) in fit elderly patients selected with a comprehensive geriatric assessment (CGA): Groupe Français de Pneumocancerologie (GFPC)0504
    • abstr 7536) In fit elderly patients (median age 75), chemotherapy followed by erlotinib at progression was numerically superior to the reverse combination
    • Le Caer H, Barlesi F, Corre R. A multicenter phase II randomized study of docetaxel (D)/gemcitabine (G) weekly followed by erlotinib (E) after progression versus erlotinib followed by docetaxel/gemcitabine after progression in advanced nonsmall cell lung cancer (NSCLC) in fit elderly patients selected with a comprehensive geriatric assessment (CGA): Groupe Français de Pneumocancerologie (GFPC)0504. J Clin Oncol 2010; 28:15s (suppl; abstr 7536). In fit elderly patients (median age 75), chemotherapy followed by erlotinib at progression was numerically superior to the reverse combination.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Le Caer, H.1    Barlesi, F.2    Corre, R.3
  • 43
    • 78649507067 scopus 로고    scopus 로고
    • International multicenter randomized phase III study of first-line erlotinib (E) followed by second-line cisplatin plus gemcitabine (CG) versus first-line CG followed by second-line E in advanced nonsmall cell lung cancer (aNSCLC): The TORCH trial
    • abstr 7508). Study evaluating sequential use of erlotinib and chemotherapy; first-line erlotinib followed by chemotherapy at progression is inferior to the reverse standard one, in unselected patients with advanced NSCL.C.
    • Gridelli C, Ciardiello F, Feld R, et al. International multicenter randomized phase III study of first-line erlotinib (E) followed by second-line cisplatin plus gemcitabine (CG) versus first-line CG followed by second-line E in advanced nonsmall cell lung cancer (aNSCLC): The TORCH trial. J Clin Oncol 2010; 28:15s (suppl; abstr 7508). Study evaluating sequential use of erlotinib and chemotherapy; first-line erlotinib followed by chemotherapy at progression is inferior to the reverse standard one, in unselected patients with advanced NSCLC.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Gridelli, C.1    Ciardiello, F.2    Feld, R.3
  • 45
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 49
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of eastern cooperative oncology group trial 4599
    • Ramalingam SS, Dahlberg SE, Langer CJ, et al. Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of eastern cooperative oncology group trial 4599. J Clin Oncol 2008; 26:60-65.
    • (2008) J Clin Oncol , vol.26 , pp. 60-65
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3
  • 50
    • 76149115427 scopus 로고    scopus 로고
    • Increased benefit from bevacizumab (BEV) in younger women with advanced NSCLC on eastern cooperate oncology group (ECOG) E4599
    • abstr 131
    • Wakelee HA, Dahlberg SE, Brahmer JR. Increased benefit from bevacizumab (BEV) in younger women with advanced NSCLC on eastern cooperate oncology group (ECOG) E4599. J Thor Oncol 2008; 3 (suppl 4):S282, abstr 131.
    • (2008) J Thor Oncol , vol.3 , Issue.SUPPL. 4
    • Wakelee, H.A.1    Dahlberg, S.E.2    Brahmer, J.R.3
  • 51
    • 78650515286 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumabbased therapy in elderly patients with advanced or recurrent nonsquamous nonsmall cell lung cancer in the phase III BO17704 study (AVAiL)
    • Leighl NB, Zatloukal P, Mezger J et al. Efficacy and safety of bevacizumabbased therapy in elderly patients with advanced or recurrent nonsquamous nonsmall cell lung cancer in the phase III BO17704 study (AVAiL). J Thorac Oncol 2010; 5:1970-1976.
    • (2010) J Thorac Oncol , vol.5 , pp. 1970-1976
    • Leighl, N.B.1    Zatloukal, P.2    Mezger, J.3
  • 52
    • 77955268612 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab-based therapy in advanced nonsquamous nonsmall-cell lung cancer (SAiL, MO19390): A phase 4 study
    • Crino L, Dansin E, Garrido P et al. Safety and efficacy of first-line bevacizumab-based therapy in advanced nonsquamous nonsmall-cell lung cancer (SAiL, MO19390): A phase 4 study. Lancet Oncol 2010; 11:733-740.
    • (2010) Lancet Oncol , vol.11 , pp. 733-740
    • Crino, L.1    Dansin, E.2    Garrido, P.3
  • 53
    • 84856812983 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and erlotinib in treatment-naive elderly patients (older than age 65) with advanced nonsmall cell lung cancer (NSCLC)
    • abstr 7548. Study of bevacizumab and erlotinib in an unselected population, more than 65 years of age, and this combination was demonstrated to be well tolerated, with an estimated median PFS of 6.6 months and estimated median OS of 14.1 months. More data including molecular profiling are awaited
    • Borghaei H, Mehra R, Millenson MM. Phase II study of bevacizumab and erlotinib in treatment-naive elderly patients (older than age 65) with advanced nonsmall cell lung cancer (NSCLC). J Clin Oncol 2011; 29 (suppl):abstr 7548. Study of bevacizumab and erlotinib in an unselected population, more than 65 years of age, and this combination was demonstrated to be well tolerated, with an estimated median PFS of 6.6 months and estimated median OS of 14.1 months. More data including molecular profiling are awaited.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Borghaei, H.1    Mehra, R.2    Millenson, M.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.