Weekly docetaxel versus docetaxel/gemcitabine in the treatment of elderly or poor performance status patients with advanced nonsmall cell lung cancer: A randomized phase 3 trial of the Minnie Pearl Cancer Research Network

Cancer

Volumn 110, Issue 9, 2007, Pages 2027-2034

  Hainsworth, John D ^a,e   Spigel, David R ^a   Farley, Cindy ^a   Shipley, Dianna L ^a   Bearden, James D ^b   Gandhi, Jitendra ^c   Houston, Gerry Ann ^d   Greco, F Anthony ^a  

^a SARAH CANNON RESEARCH INSTITUTE   (United States)

^b Gibbs Cancer Center and Research Institute   (United States)

^c Associates in Oncology and Hematology   (United States)

^d Jackson Oncology Associates   (United States)

^e NONE   (United States)

Author keywords

Docetaxel; Elderly patients; Gemcitabine; Nonsmall cell lung cancer; Poor performance status patients; Stage IV NSCLC

Indexed keywords

DOCETAXEL; GEMCITABINE;

ADULT; AGED; ANEMIA; ARTHRALGIA; ARTICLE; BLEEDING; CANCER STAGING; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG HYPERSENSITIVITY; EDEMA; ELDERLY CARE; ERYTHROCYTE TRANSFUSION; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HEMATOLOGIC DISEASE; HUMAN; HYPERGLYCEMIA; HYPERSENSITIVITY REACTION; LACRIMATION DISORDER; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MYALGIA; NAIL DISEASE; NAUSEA; NEUTROPENIA; PERIPHERAL NEUROPATHY; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SIDE EFFECT; STOMATITIS; SURVIVAL TIME; THROMBOCYTOPENIA;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; DEOXYCYTIDINE; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED; TAXOIDS;

EID: 35648934612     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.23019     Document Type: Article

References (19)

1. D'Addario G, Pintilie M, Leighl NB, et al. Platinum-based versus non-platinum-based chemotherapy in advanced non-small cell lung cancer: A meta-analysis of the published literature. J Clin Oncol. 2005;23:2926-2936.
2. Lilenbaum RC, Herndon JE, List MA, et al. Single-agent versus combination chemotherapy in advanced non-small cell lung cancer: The Cancer and Leukemia Group B (study 9730). J Clin Oncol. 2005;23:190-196.
3. Sederholm C, Hillardal G, Lamberg K, et al. Phase III trial of gemcitabine plus carboplatin versus single-agent gemcitabine in the treatment of locally advanced or metastatic non-small cell lung cancer: The Swedish Lung Cancer Study Group. J Clin Oncol. 2005;23:8380-8388.
4. Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med. 2002;346:92-98.
5. Langer CJ, Manola J, Bernardo P, et al. Cisplatin-based therapy for elderly patients with advanced non-small cell lung cancer: Implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst. 2002;94: 173-181.
6. Belani CP, Fossella F. Elderly subgroup analysis of a randomized phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for first-line treatment of advanced nonsmall cell lung cancer (TAX326). Cancer. 2005;104:2766-2774.
7. Sweeney CJ, Zhu J, Sandler AB, et al. Outcome of patients with a performance status of 2 in Eastern Cooperative Oncology Study E1594: a phase III trial in patients with metastatic nonsmall cell lung carcinoma. Cancer. 2001;92:2639-2647.
8. Gridelli C, Perrone F, Gallo C, et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst. 2003;95:362-372.
9. Hainsworth JD, Burns HA 3rd, Litchy S, et al. Weekly docetaxel in the treatment of elderly patients with advanced nonsmall cell lung carcinoma. A Minnie Pearl Cancer Research Network Phase II Trial. Cancer. 2000;89:328-333.
10. Kudoh S, Takeda K, Nakagawa K, et al. Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer: results of The West Japan Thoracic Oncology Group trial (WJOG 9904). J Clin Oncol. 2006;24:3657-3663.
11. Hainsworth JD, Erland JB, Barton JH, et al. Combination treatment with weekly docetaxel and gemcitabine for elderly/poor performance status patients with advanced non-small cell lung cancer: Results of a Minnie Pearl Cancer Research Network Phase II Trial. Clin Lung Cancer. 2003;5:33-38.
12. World Health Organization. Handbook for Reporting Results of Cancer Treatment. Geneva: World Health Organization; 1979.
13. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
14. Nguyen B, Sandler A, Denham C: The safety and efficacy of gemcitabine plus cisplatin in the elderly chemo-naive NSCLC patients (age ≥70 years) as compared to those with age <70 years [abstract]. Proc Am Soc Clin Oncol. 1999;18: 471a. (Abstract 1818).
15. Hensing TA, Peterman AH, Schell MJ, et al. The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, stage IIIB or IV non-small cell lung cancer treated with carboplatin and paclitaxel. Cancer. 2003;98:779-788.
16. Langer CJ, Vangel M, Schiller J, et al. Age-specific subanalysis of ECOG 1594: fit elderly patients (70-80 yrs) with NSCLC do as well as younger patients (<70) [abstract]. Proc Am Soc Clin Oncol. 2003;22:639. (Abstract 2571).
17. Hesketh PJ, Lilenbaum R, Chansky K, et al. Chemotherapy in patients ≥80 with advanced non-small cell lung cancer, combined results from SWOG 0027 and LUN 6 [abstract]. J Clin Oncol. 2005;23:657s. (Abstract 7147).
18. Elderly Lung Cancer Vinorelbine Italian Study Group: effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small cell lung cancer. J Natl Cancer Inst. 1999;91:66-72.
19. Frasci G, Lorasso V, Panza N, et al. Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small cell lung cancer. J Clin Oncol. 2000; 18:2529-2536.