Pathophysiological consequences of brain death

Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft

Volumn 23, Issue 3, 2011, Pages 140-145

  Weymann, Alexander ^a   Schmack, Bastian ^a   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Brain death; Donor heart; Heart transplantation

Indexed keywords

EID: 84856808650     PISSN: 09469648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Szabo G, Hackert T, Sebening C, Vahl CF, Hagl S (1999) Modulation of coronary perfusion pressure can reverse myocardial dysfunction after brain death. Ann Thorac Surg 67: 18-25
2. Herijgers P, Borgers M, Flameng W (1998) The effect of brain death on cardiovascular function in rats. Part I. Is the heart damaged? Cardiovasc Res 38: 98-106
3. Galinanes M, Hearse DJ (1994) Brain-death-induced cardiac contractile dysfunction: studies of possible neurohormonal and blood borne mediators. J Mol Cell Cardiol 26: 481-498
4. Bruinsma GJBB,Nederhoff MGJ,Geertman HJ,van Huffelen AC, Slootweg PJ, Ferrari R, Galinanes M, Hearse DJ, Bredeâe JJ, Ruigrok TJC (1997) Acute increase of myocardial workload, hemodynamic instability and myocardial histologic changes induced by brain death in the cat. J Surg Res 68: 7-15
5. Baroldi G, Di Pasquale G, Silver MD, Pinelli G, Lusa AM, Fineschi V (1997) Type and extent of myocardial injury related to brain damage and its significance in heart transplantation: a morphometric study. J Heart Lung Transplant 16: 994-1000
6. Novitzky D, Wicomb WN, Cooper DKC, Rose AG, Fraser RC, Barnard CN (1984) Electrocardiographic, haemodynamic, and endocrine changes occurring during experimental brain death in the Chacma baboon. Heart Transplant 4: 63-69
7. Meyers CH, D'Amico TA, Peterseim DS, Jayawant AM, Steenbergen C, Sabiston DC, Van Trigt P (1993) Effects of triiodothyronine and vasopressin on cardiac function and myocardial blood flow after brain death. J Heart Lung Transplant 12: 68-80
8. Wheeldon DR, Potter CD, Oduro A, Wallwork J, Large S (1995) Transforming the 'unacceptable' donor: outcomes from the adoption of standardized donor management technique. J Heart Lung Transplant 14: 734-742
9. Szabo G, Sebening C, Hackert T, Hagl C, Tochtermann U, Vahl CF, Hagl S (1998) Effects of brain death on myocardial function and ischemic tolerance of potential donor hearts. J Heart Lung Transplant 17: 921-930
10. Szabo G, Sebening C, Hagl C,Tochtermann U,Vahl CF, Hagl S (1998) Right ventricular function after brain death: response to an increased afterload. Eur J Cardio-thorac Surg 13: 449-459
11. Szabo G, Hackert T, Sebening C, Melnitschuk S, Vahl CF, Hagl S (2000) Role of neural and humoral factors in hyperdynamic reaction and cardiac dysfunction following brain death. J Heart Lung Transplant 19: 683-693
12. Galinanes M, Hearse DJ (1992) Brain death-induced impairment of cardiac contractile performance can be reversed by explantation and may not preclude the use of the hearts for transplantation. Circ Res 71: 1213
13. Sebening C, Hagl C, Szabó G et al. (1995) Cardiocirculatory effects of acutely increased intracranial pressure and subsequent brain death. Eur J Cardiothorac Surg 9: 360-72
14. Shivalkar B, Van Loon J, Wieland W, Tjandra-Maga TB, Borgers M, Plets C, Flameng W (1993) Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 87: 230-39
15. Huber TS, Groh MA, Gallagher KP, D'Alecy LG (1993) Myocardial contractility in a canine model of the brain-dead organ donor. Crit Care Med 21: 1731-9
16. Szabo G, Hackert T, Buhmann V et al. (2001) Downregulation of myocardial contractility via intact ventriculo-arterial coupling in the brain dead organ donor. Eur J Cardio-Thorac Surg 20: 170-176
17. Bittner HB, Chen EP, Milano CA et al. (1995) Myocardial β-adrenergic receptor function and high energy phosphates in brain death-related cardiac dysfunction. Circulation 92 (Suppl II): 472-8
18. Sunagawa K,Maughan D, Burkhoff D, Sagakawa K (1983) Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol 254: H773-H780
19. Herijgers P, Flameng W (1998) The effect of brain death on cardiovascular function in rats. Part II. The cause of the in vivo haemodynamic changes. Cardiovasc Res 38: 107-15
20. Herijgers P, Leunens V, Tjandra-Maga TB, Mubagwa K, Flameng W (1996) Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 62: 330-5
21. Szabo G, Buhmann V, Bährle S, Vahl CF, Hagl S (2002) Brain death impairs coronary endothelial function.Transplantation 73: 1846-8
22. Szabo G (2004) Physiologic changes after brain death. J Heart Lung Transplant 23 (9): S223-6
23. Cooper DK, Novitzky D, Wicomb DN (1989) The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. Ann R Coll Surg Engl 71 (4): 261-6
24. Klautz RJM,Teitel DF, Steendijk P,Van Bel F, Baan J (1995) Interaction between afterload and contractility in the newborn heart: evidence of homeometric autoregulation in the intact circulation. JAMA 25: 1428-35
25. Asanoi H, Ishizaka S, Kameyama T, Sasayama S (1994) Neural modulation of ventriculoarterial coupling in conscious dogs. Am J Physiol 266: H741-H748
26. Bluhm WF, Lew WYW (1995) Sarcoplasmatic reticulum in cardiac length-dependent activation in rabbits. Am J Physiol 269: H965-H972