Cranberry and Warfarin interaction: A case report and review of the literature

Consultant Pharmacist

Volumn 27, Issue 1, 2012, Pages 58-65

  Haber, Stacy L ^a   Cauthon, Kimberly A B ^a   Raney, Erin C ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

Cranberry; Drug interaction; Warfarin

Indexed keywords

WARFARIN;

AGED; ANAMNESIS; ARTICLE; BLEEDING; CASE REPORT; CRANBERRY; DIETARY INTAKE; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DOSE REGIMEN; FEMALE; FOOD DRUG INTERACTION; HEART ATRIUM FIBRILLATION; HEART FAILURE; HUMAN; INTERNATIONAL NORMALIZED RATIO; PATIENT TRANSPORT; VEIN PUNCTURE;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ATRIAL FIBRILLATION; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; INTERNATIONAL NORMALIZED RATIO; VACCINIUM MACROCARPON; WARFARIN;

EID: 84856805097     PISSN: 08885109     EISSN: None     Source Type: Journal    
DOI: 10.4140/TCP.n.2012.58     Document Type: Article

References (17)

1. Ansell J, Hirsh J, Hylek E et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008;133 Suppl 6:160-98.
2. Coumadin (warfarin sodium) package insert. Princeton, NJ: Bristol-Myers Squibb; 2010.
3. Natural Standard. Cranberry (Vaccinium macrocarpon). Available at http://www.naturalstandard.com. Accessed July 22, 2010.
4. Greenblatt DJ, von Moltke LL, Perloff ES et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. (Pubitemid 43071237)
5. Grenier J, Fradette C, Morelli G et al. Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clin Pharmacol Ther 2006;79:255-62.
6. Ngo N, Yan Z, Graf TN et al. Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans. Drug Metab Dispos 2009;37:514-22.
7. Grant P. Warfarin and cranberry juice: an interaction? J Heart Valve Dis 2004;13:25-6.
8. Rindone JP, Murphy TW. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2005;13:283-4. (Pubitemid 44026198)
9. Welch JM, Forster K. Probable elevation in international normalized ratio from cranberry juice. J Pharm Technol 2007;23:104-7. (Pubitemid 46608837)
10. Paeng CH, Sprague M, Jackevicius CA. Interaction between warfarin and cranberry juice. Clin Ther 2007;29:1730-5. (Pubitemid 47494551)
11. Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice and warfarin. J R Soc Promot Health 2008;128:324-6.
12. Mergenhagen KA, Sherman O. Elevated international normalized ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health Syst Pharm 2008;65:2113-6.
13. Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam-probes of CYP2C9, CYP1A2, and CYP3A4. Clin Pharmacol Ther 2007;81:833-9. (Pubitemid 46788294)
14. Mohammed Abdul MI, Jiang X, Williams KM et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700.
15. Li Z, Seeram NP, Carpenter CL et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. (Pubitemid 44779450)
16. Ansell J, McDonough M, Zhao Y et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30.
17. Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother 2007;41:74-80.