The absence of an interaction between warfarin and cranberry juice: A randomized, double-blind trial

Journal of Clinical Pharmacology

Volumn 49, Issue 7, 2009, Pages 824-830

  Ansell, Jack ^a,c   McDonough, Maryellen ^a   Zhao, Yanli ^b   Harmatz, Jerold S ^b   Greenblatt, David J ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LENOX HILL HOSPITAL   (United States)

Author keywords

Anticoagulation; Drug interactions; Supplements; Warfarin

Indexed keywords

PLACEBO; WARFARIN;

ADULT; ANTICOAGULATION; ARTICLE; BEVERAGE; CLINICAL ARTICLE; CLINICAL TRIAL; COLOR; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRANBERRY JUICE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; FOLLOW UP; FOOD DRUG INTERACTION; HUMAN; INTERNATIONAL NORMALIZED RATIO; MALE; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; TASTE;

ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BEVERAGES; DOUBLE-BLIND METHOD; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; MIDDLE AGED; VACCINIUM MACROCARPON; WARFARIN;

EID: 67650446990     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270009337510     Document Type: Article

References (21)

1. Ansell J., Hirsh J., Hylek E., Jacobson A., Crowther M., Palareti G. The pharmacology and management of the vitamin K antagonists: ACCP evidence-based clinical practice guidelines. Chest. 2008 ; 133: 160S - 198S.
2. Yamazaki H., Shimada T. Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers. Biochem Pharmacol. 1997 ; 54: 1195-1203. (Pubitemid 27497246)
3. Rettie AE, Korzekwa KR, Kunze KL, et al. Hydroxylation of warfarin by human cDNA-expressed cytochrome P450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem Res Toxicol. 1992 ; 5: 54-59.
4. Kaminsky LS, Zhang Z. -Y. Human P450 metabolism of warfarin. Pharmacol Ther. 1997 ; 73: 67-74. (Pubitemid 26425815)
5. Kaminsky LS, de Morais SMF, Faletto MB, Dunbar DA, Goldstein JA Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe. Mol Pharmacol. 1993 ; 43: 234-239. (Pubitemid 23055067)
6. Holbrook AM, Pereira JA, Labiris R., et al. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med. 2005 ; 165: 1095-1106. (Pubitemid 40720733)
7. Suvarna R., Pirmohamed M., Henderson L. Possible interaction between warfarin and cranberry juice. BMJ. 2003 ; 327: 1454. (Pubitemid 38045820)
8. Grant P. Warfarin and cranberry juice: an interaction ? J Heart Valve Surg. 2004 ; 13: 25-26.
9. Rindone JP, Murphy TW Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Amer J Therap. 2005 ; 13: 283-284.
10. Welch JM, Forster K. Probable elevation in international normalized ratio from cranberry juice. J Pharm Technol. 2007 ; 23: 104-107. (Pubitemid 46608837)
11. Paeng CH, Sprague M., Jackevicius CA Interaction between warfarin and cranberry juice. Clin Ther. 2007 ; 29: 1730-1735. (Pubitemid 47494551)
12. Medicines and Healthcare Products Regulatory Agency/ Committee on Safety of Medicines. Interaction between warfarin and cranberry juice: new advice. Curr Probl Pharmacovigilance. 2003 ; 30: 10
13. Osman A., Arbring K., Lindahl TL A new high-performance liquid chromatographic method for determination of warfarin enantiomers. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 ; 826: 75-80. (Pubitemid 41446437)
14. Ufer M. Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005 ; 44: 1227-1246. (Pubitemid 41832565)
15. Aston JL, Lodolce AE, Shapiro NL Interaction between warfarin and cranberry juice. Pharmacotherapy. 2006 ; 26: 1314-1319. (Pubitemid 44313758)
16. Pham DQ, Pham AQ Interaction potential between cranberry juice and warfarin. Am J Health Syst Pharm. 2007 ; 64: 490-494. (Pubitemid 46339262)
17. Greenblatt DJ, von Moltke LL Interaction of warfarin with drugs, natural substances, and foods. J Clin Pharmacol. 2005 ; 45: 127-132. (Pubitemid 40490435)
18. Lilja JJ, Backman JT, Neuvonen PJ Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam: probes of CYP2C9, CYP1A2, and CYP3A4. Clin Pharmacol Therap. 2007 ; 81: 833-839. (Pubitemid 46788294)
19. Li Z., Seeram NP, Carpenter CL, Thames G., Minutti C., Bowerman S. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc. 2006 ; 106: 2057-2061. (Pubitemid 44779450)
20. Abdul MI, Jiang X., Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol. 2008 ; 154: 1691-1700.
21. Greenblatt DJ, von Moltke LL, Perloff ES, Luo Y., Harmatz JS, Zinny MA Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther. 2006 ; 79: 125-133. (Pubitemid 43071237)